Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Arachidonate 15-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Arachidonate 15-lipoxygenase | 663 aa | 676 aa | 22.5 % |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Arachidonate 15-lipoxygenase | 663 aa | 676 aa | 23.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2603 | 0.2898 | 0.2898 |
Loa Loa (eye worm) | hypothetical protein | 0.2603 | 0.2898 | 1 |
Echinococcus granulosus | cathepsin b | 0.2603 | 0.2898 | 1 |
Echinococcus granulosus | cathepsin b | 0.2603 | 0.2898 | 1 |
Echinococcus multilocularis | cathepsin b | 0.2603 | 0.2898 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0859 | 0.0676 | 0.2333 |
Onchocerca volvulus | 0.0328 | 0 | 0.5 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0859 | 0.0676 | 0.0676 |
Plasmodium vivax | aspartyl protease, putative | 0.0328 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0328 | 0 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0328 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin I | 0.0328 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin X | 0.0328 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin IX | 0.0328 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0859 | 0.0676 | 0.5 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.2603 | 0.2898 | 1 |
Onchocerca volvulus | 0.0328 | 0 | 0.5 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2603 | 0.2898 | 0.2898 |
Plasmodium falciparum | plasmepsin VII | 0.0328 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.2603 | 0.2898 | 1 |
Toxoplasma gondii | cathepsin B | 0.0859 | 0.0676 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0328 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.2603 | 0.2898 | 1 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0328 | 0 | 0.5 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0859 | 0.0676 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0328 | 0 | 0.5 |
Plasmodium vivax | aspartyl protease, putative | 0.0328 | 0 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0328 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin III | 0.0328 | 0 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.2603 | 0.2898 | 0.2898 |
Plasmodium vivax | plasmepsin V, putative | 0.0328 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin II | 0.0328 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0859 | 0.0676 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0859 | 0.0676 | 0.5 |
Plasmodium falciparum | plasmepsin V | 0.0328 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2603 | 0.2898 | 0.2898 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0859 | 0.0676 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0859 | 0.0676 | 0.5 |
Plasmodium vivax | aspartyl protease, putative | 0.0328 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.