TDR Targets

Basic information

Technical information

TDR Targets ID: 453508
Name: 2-[2-(3-chlorophenyl)ethynyl]-6-methylpyridin e
MW: 227.689 | Formula: C14H10ClN
H donors: 0 H acceptors: 1 LogP: 3.94 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)C#Cc1cccc(n1)C
InChi: 1S/C14H10ClN/c1-11-4-2-7-14(16-11)9-8-12-5-3-6-13(15)10-12/h2-7,10H,1H3
InChiKey: PHMIEAGFDRJBOP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[2-(3-chlorophenyl)ethynyl]-6-methyl-pyridine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, metabotropic 5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	Metabotropic glutamate receptor precursor.	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	ko:K04606 glutamate receptor, metabotropic 3, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	Metabotropic glutamate receptor precursor, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	beta-lactamase	0.0035	0.0074	0.087
Echinococcus multilocularis	fmrfamide receptor	0.0202	0.0642	0.2394
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0041	0.0095	0.0719
Echinococcus granulosus	geminin	0.0164	0.0512	0.4709
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0202	0.0642	0.595
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0074	0.0054
Schistosoma mansoni	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	tumor protein p63	0.0326	0.1065	0.4023
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0202	0.0642	0.2394
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0186	0.2672
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0202	0.0642	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0074	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Echinococcus granulosus	sex peptide receptor	0.0202	0.0642	0.595
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.0292	0.4386
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0062	0.0407
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0202	0.0642	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0202	0.0642	0.2394
Brugia malayi	beta-lactamase family protein	0.0035	0.0074	0.087
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Brugia malayi	neuropeptide F receptor	0.0202	0.0642	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.002	0.001
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Echinococcus granulosus	7tm_1 domain containing protein	0.0202	0.0642	0.595
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0202	0.0642	0.2394
Brugia malayi	putative neuropeptide receptor	0.0202	0.0642	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0089	0.0259	0.3854
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0202	0.0642	1
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Leishmania major	DNA polymerase kappa, putative	0.0019	0.002	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0019	0.002	0.001
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	neuropeptide s receptor	0.0202	0.0642	0.2394
Onchocerca volvulus		0.0202	0.0642	1
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0202	0.0642	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0019	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0202	0.0642	0.595
Mycobacterium ulcerans	isocitrate lyase AceAb	0.2955	1	1
Brugia malayi	Serotonin receptor	0.0202	0.0642	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.002	0.0002
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0074	0.0054
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.002	0.001
Echinococcus granulosus	dna polymerase kappa	0.0019	0.002	0.0006
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0019	0.2646
Loa Loa (eye worm)	neuropeptide F receptor	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	serotonin receptor	0.0202	0.0642	0.2394
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0074	0.0054
Schistosoma mansoni	biogenic amine receptor	0.0202	0.0642	1
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.006	0.016	0.0541
Brugia malayi	Melatonin receptor type 1A	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.158
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	g protein coupled receptor	0.0202	0.0642	0.595
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	neuropeptide receptor	0.0202	0.0642	0.2394
Schistosoma mansoni	biogenic amine receptor	0.0202	0.0642	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0202	0.0642	0.2394
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.002	0.001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.002	0.0002
Echinococcus granulosus	neuropeptides capa receptor	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	tumor protein p63	0.0326	0.1065	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Echinococcus multilocularis	neuropeptide Y receptor	0.0202	0.0642	0.2394
Schistosoma mansoni	biogenic amine receptor	0.0202	0.0642	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0202	0.0642	1
Brugia malayi	AKH receptor	0.0202	0.0642	1
Brugia malayi	larval opioid receptor	0.0202	0.0642	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0202	0.0642	1
Brugia malayi	sulfakinin receptor protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Echinococcus multilocularis	g protein coupled receptor	0.0202	0.0642	0.2394
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0074	1
Echinococcus multilocularis	sex peptide receptor	0.0202	0.0642	0.2394
Echinococcus granulosus	neuropeptides capa receptor	0.0202	0.0642	0.595
Schistosoma mansoni	neuropeptide receptor	0.0202	0.0642	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0074	0.0208
Schistosoma mansoni	neuropeptide f receptor 76f	0.0202	0.0642	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0202	0.0642	0.595
Echinococcus granulosus	g-protein coupled receptor	0.0202	0.0642	0.595
Echinococcus granulosus	neuropeptide Y receptor	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0202	0.0642	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.002	0.0109
Brugia malayi	GnHR receptor homolog	0.0202	0.0642	1
Onchocerca volvulus		0.0202	0.0642	1
Schistosoma mansoni	hypothetical protein	0.0202	0.0642	1
Brugia malayi	metabotropic glutamate receptor type 2	0.0024	0.0036	0.0272
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0202	0.0642	0.595
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0202	0.0642	0.2394
Echinococcus granulosus	7TM GPCR rhodopsin	0.0202	0.0642	0.595
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0049	0.0122	0.1642
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0202	0.0642	0.2394
Toxoplasma gondii	ABC1 family protein	0.0035	0.0074	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.087
Onchocerca volvulus		0.0202	0.0642	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0202	0.0642	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0202	0.0642	0.2394
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0202	0.0642	0.2394
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0074	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0202	0.0642	1
Brugia malayi	follicle stimulating hormone receptor	0.0202	0.0642	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0202	0.0642	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0202	0.0642	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0202	0.0642	0.2394
Onchocerca volvulus		0.0202	0.0642	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0202	0.0642	0.595
Echinococcus granulosus	tm gpcr rhodopsin	0.0202	0.0642	0.595
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Trypanosoma brucei	unspecified product	0.0019	0.002	0.2727
Schistosoma mansoni	neuropeptide receptor	0.0202	0.0642	1
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0044	0.0106	0.139
Schistosoma mansoni	adenoreceptor	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0202	0.0642	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0202	0.0642	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0062	0.0684
Loa Loa (eye worm)	hypothetical protein	0.006	0.016	0.2259
Schistosoma mansoni	neuropeptide receptor	0.0202	0.0642	1
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0074	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0062	0.0164
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0783	0.2619	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0202	0.0642	1
Brugia malayi	Dopamine receptor protein 2	0.0202	0.0642	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Echinococcus granulosus	neuropeptide receptor A26	0.0202	0.0642	0.595
Mycobacterium tuberculosis	Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl)	0.2955	1	1
Echinococcus granulosus	serotonin receptor	0.0202	0.0642	0.595
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0056	0.0144	0.2008
Brugia malayi	RE15519p	0.0202	0.0642	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0089	0.0259	0.3854
Echinococcus granulosus	biogenic amine 5HT receptor	0.0202	0.0642	0.595
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.002	0.0001
Mycobacterium ulcerans	lipase LipD	0.0035	0.0074	0.0054
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0019	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0202	0.0642	0.595
Echinococcus granulosus	dna polymerase eta	0.0019	0.002	0.0006
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.002	0.0109
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0202	0.0642	0.2394
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.002	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Brugia malayi	putative neuropeptide receptor NPR1	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0074	0.0054
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0074	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0202	0.0642	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0202	0.0642	0.2394
Onchocerca volvulus		0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0202	0.0642	1
Onchocerca volvulus		0.0202	0.0642	1
Schistosoma mansoni	opsin-like receptor	0.0202	0.0642	1
Mycobacterium tuberculosis	Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl)	0.2955	1	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0074	0.087
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0062	0.0684
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0259	0.3854
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Echinococcus granulosus	neuropeptide s receptor	0.0202	0.0642	0.595
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.0259	0.0923
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.0259	0.2293
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	DNA polymerase eta	0.0019	0.002	0.001
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0259	0.3854
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	hypothetical protein	0.0164	0.0512	0.7914
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.087
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.002	0.001
Schistosoma mansoni	opsin-like receptor	0.0202	0.0642	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0074	0.087
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0202	0.0642	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0062	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0186	0.2672
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0202	0.0642	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.002	0.0109
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0202	0.0642	0.2394
Trichomonas vaginalis	esterase, putative	0.0035	0.0074	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0074	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0062	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.002	0.0109
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0074	1
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0062	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.087
Schistosoma mansoni	amine GPCR	0.0202	0.0642	1
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0062	0.0684
Brugia malayi	Dopamine receptor protein 1	0.0202	0.0642	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0202	0.0642	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0202	0.0642	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0202	0.0642	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.0259	0.2293
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0202	0.0642	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0202	0.0642	0.2394
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0202	0.0642	0.595
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0202	0.0642	1
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0118	0.158
Echinococcus multilocularis	g-protein coupled receptor	0.0202	0.0642	0.2394
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0062	0.0684
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0202	0.0642	0.595
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0202	0.0642	0.2394
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.0259	0.0923
Schistosoma mansoni	metabotropic glutamate receptor	0.0024	0.0036	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.087
Onchocerca volvulus		0.0202	0.0642	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0202	0.0642	1
Mycobacterium ulcerans	isocitrate lyase Icl	0.2955	1	1
Mycobacterium leprae	Isocitrate lyase	0.1385	0.4664	0.4624
Schistosoma mansoni	hypothetical protein	0.0031	0.0062	0.0684
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0074	0.087
Schistosoma mansoni	hypothetical protein	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.002	0.2727
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0062	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0074	0.0054
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0222	0.0711	0.0693
Onchocerca volvulus		0.0202	0.0642	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.002	0.0109
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0019	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0202	0.0642	0.2394
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0202	0.0642	0.595
Loa Loa (eye worm)	G-protein coupled receptor	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Echinococcus multilocularis	geminin	0.0164	0.0512	0.1895
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.002	0.0001
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0074	0.087
Echinococcus granulosus	dro:myosuppressin receptor	0.0202	0.0642	0.595
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0202	0.0642	1
Schistosoma mansoni	amine GPCR	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Echinococcus granulosus	orexin receptor type 2	0.0202	0.0642	0.595
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.002	0.2727
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Echinococcus multilocularis	serotonin receptor	0.0202	0.0642	0.2394
Schistosoma mansoni	hypothetical protein	0.0164	0.0512	0.7914
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0202	0.0642	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0202	0.0642	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0074	1
Leishmania major	DNA polymerase eta, putative	0.0019	0.002	0.0109
Echinococcus multilocularis	allatostatin A receptor	0.0202	0.0642	0.2394
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0202	0.0642	0.2394
Echinococcus granulosus	fmrfamide receptor	0.0202	0.0642	0.595
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0259	0.3854
Schistosoma mansoni	hypothetical protein	0.0068	0.0186	0.2672
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.0292	0.4386
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0202	0.0642	1
Echinococcus granulosus	hypothetical protein	0.0202	0.0642	0.595
Echinococcus multilocularis	g protein coupled receptor	0.0202	0.0642	0.2394
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Brugia malayi	Serotonin receptor	0.0202	0.0642	1
Schistosoma mansoni	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.002	0.0001
Echinococcus granulosus	allatostatin A receptor	0.0202	0.0642	0.595
Loa Loa (eye worm)	TYRA-2 protein	0.0202	0.0642	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0062	0.0407
Schistosoma mansoni	amine GPCR	0.0202	0.0642	1
Brugia malayi	neuropeptide F receptor	0.0202	0.0642	1
Brugia malayi	G-protein coupled receptor	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.087
Schistosoma mansoni	opsin-like receptor	0.0202	0.0642	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0202	0.0642	1
Echinococcus multilocularis	neuropeptide receptor	0.0202	0.0642	0.2394
Echinococcus multilocularis	g protein coupled receptor	0.0202	0.0642	0.2394
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0074	1
Onchocerca volvulus		0.0202	0.0642	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0074	0.0054
Onchocerca volvulus		0.0202	0.0642	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0202	0.0642	1
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0041	0.0095	0.0289
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0202	0.0642	1
Brugia malayi	G-protein coupled receptor	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.002	0.2727
Schistosoma mansoni	neuropeptide receptor	0.0202	0.0642	1
Schistosoma mansoni	metabotropic glutamate receptor	0.0041	0.0095	0.1208
Echinococcus multilocularis	G protein coupled receptor 139	0.0202	0.0642	0.2394
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0202	0.0642	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0202	0.0642	0.595
Leishmania major	hypothetical protein, conserved	0.0035	0.0074	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0074	0.087
Onchocerca volvulus		0.0202	0.0642	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0202	0.0642	1
Echinococcus granulosus	neuropeptide receptor	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0202	0.0642	1
Brugia malayi	ORL1-like opioid receptor	0.0202	0.0642	1
Loa Loa (eye worm)	glutamate receptor	0.0049	0.0122	0.1642
Onchocerca volvulus		0.0048	0.0118	0.0778
Echinococcus granulosus	somatostatin receptor	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0074	0.0518
Echinococcus granulosus	neuropeptide FF receptor 2	0.0202	0.0642	0.595
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.002	0.0109
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.002	0.001
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.087
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Brugia malayi	G protein-coupled receptor	0.0202	0.0642	1
Onchocerca volvulus		0.0202	0.0642	1
Onchocerca volvulus		0.0202	0.0642	1
Schistosoma mansoni	histamine h1 receptor	0.0202	0.0642	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0074	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0202	0.0642	0.2394
Echinococcus granulosus	neuropeptide Y receptor	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Onchocerca volvulus		0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.002	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0292	0.4386
Onchocerca volvulus		0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0074	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0202	0.0642	0.595
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.0292	0.4386
Echinococcus granulosus	rhodopsin orphan GPCR	0.0202	0.0642	0.595
Echinococcus granulosus	G protein coupled receptor 139	0.0202	0.0642	0.595
Schistosoma mansoni	hypothetical protein	0.0031	0.0062	0.0684
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.002	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Echinococcus multilocularis	somatostatin receptor	0.0202	0.0642	0.2394
Echinococcus multilocularis	neuropeptide Y receptor	0.0202	0.0642	0.2394
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0202	0.0642	0.2394
Echinococcus granulosus	metabotropic glutamate receptor 5	0.006	0.016	0.1344
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.002	0.2727
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0074	0.0054
Onchocerca volvulus		0.0202	0.0642	1
Echinococcus multilocularis	orexin receptor type 2	0.0202	0.0642	0.2394
Schistosoma mansoni	myosin xvIII	0.0202	0.0642	1
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0074	0.0054
Echinococcus granulosus	neuropeptide receptor	0.0202	0.0642	0.595
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0202	0.0642	0.2394
Echinococcus granulosus	g protein coupled receptor	0.0202	0.0642	0.595
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Echinococcus granulosus	GPCR family 2	0.0031	0.0062	0.0407
Echinococcus multilocularis	dna polymerase eta	0.0019	0.002	0.0002
Giardia lamblia	DINP protein human, muc B family	0.0019	0.002	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0074	0.0054
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0202	0.0642	0.2394
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.002	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0074	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Brugia malayi	hypothetical protein	0.0202	0.0642	1
Schistosoma mansoni	amine GPCR	0.0202	0.0642	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0074	0.0054
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0074	0.087
Schistosoma mansoni	neuropeptide F-like receptor	0.0202	0.0642	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0202	0.0642	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.002	0.0109
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0202	0.0642	1
Onchocerca volvulus		0.0202	0.0642	1
Mycobacterium tuberculosis	Isocitrate lyase Icl (isocitrase) (isocitratase)	0.2955	1	1
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0074	0.0054
Echinococcus granulosus	g protein coupled receptor	0.0202	0.0642	0.595
Brugia malayi	Dopamine receptor	0.0202	0.0642	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0202	0.0642	0.2394
Echinococcus multilocularis	fmrfamide receptor	0.0202	0.0642	0.2394
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.002	0.2727
Schistosoma mansoni	amine GPCR	0.0202	0.0642	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0642	1
Loa Loa (eye worm)	glutamate receptor	0.0019	0.0021	0.0021

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3 nM	Displacement of [3H]MPEP from mGlu5 receptor	ChEMBL.	17196387
IC50 (binding)	= 3 nM	Displacement of [3H]MPEP from mGlu5 receptor	ChEMBL.	17196387
IC50 (functional)	= 7 nM	Antagonist activity at mGluR5 by FLIPR	ChEMBL.	17196387
IC50 (functional)	= 7 nM	Antagonist activity at mGluR5 by FLIPR	ChEMBL.	17196387

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL245404
PubChem: 18763270

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 453508