Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.1522 | 0.1921 |
Echinococcus multilocularis | geminin | 0.0177 | 0.6981 | 0.6912 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0564 | 0.0348 |
Onchocerca volvulus | 0.005 | 0.1522 | 1 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.2642 | 0.2474 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0564 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0542 | 0.0542 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0564 | 0.0564 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0223 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0223 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.1522 | 0.1522 |
Schistosoma mansoni | lamin | 0.0028 | 0.0564 | 0.0504 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.2084 | 0.1903 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0223 | 0.0223 |
Echinococcus granulosus | geminin | 0.0177 | 0.6981 | 0.6912 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0223 | 0.5 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0564 | 0.0348 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.2642 | 0.2474 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0223 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0223 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.2642 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2084 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0223 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0223 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.2084 | 1 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0564 | 0.0348 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.2084 | 0.2754 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.2084 | 0.1903 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0564 | 0.0564 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.2084 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.2642 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0564 | 0.0348 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.6981 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.2642 | 0.3579 |
Echinococcus granulosus | lamin | 0.0028 | 0.0564 | 0.0348 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.2084 | 0.2754 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.6981 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0223 | 0.0223 |
Schistosoma mansoni | lamin | 0.0028 | 0.0564 | 0.0504 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0564 | 0.0564 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0247 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.2084 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2084 | 1 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.1522 | 0.1921 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2084 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.2642 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0247 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0076 | 0.2642 | 0.2642 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0564 | 0.0564 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0223 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0564 | 0.0564 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0223 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.2642 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0223 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0564 | 0.0504 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.2642 | 0.3579 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.