Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | prolyl oligopeptidase | 0.4723 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.1588 | 0.2791 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.1588 | 0.2791 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0374 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0374 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0374 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.4723 | 1 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0374 | 0 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0374 | 0 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.4723 | 1 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.1588 | 0.2791 | 1 |
Brugia malayi | hypothetical protein | 0.1214 | 0.193 | 0.193 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0374 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1214 | 0.193 | 0.193 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0374 | 0 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0374 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0374 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0374 | 0 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.1588 | 0.2791 | 0.2791 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1588 | 0.2791 | 0.2791 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.4723 | 1 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.1588 | 0.2791 | 0.2791 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.4723 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0374 | 0 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0374 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.1588 | 0.2791 | 1 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0374 | 0 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.1588 | 0.2791 | 0.2791 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0374 | 0 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.1588 | 0.2791 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0374 | 0 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.1588 | 0.2791 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0374 | 0 | 0.5 |
Plasmodium falciparum | peptidase, putative | 0.0374 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 28.5 nM | Inhibition of FTase by fluorescence spectrometry technique | ChEMBL. | 17827015 |
IC50 (binding) | = 28.5 nM | Inhibition of FTase by fluorescence spectrometry technique | ChEMBL. | 17827015 |
IC50 (functional) | > 100 uM | Antiproliferative activity against DU145 cells by colorimetric MTT assay | ChEMBL. | 17827015 |
IC50 (functional) | > 100 uM | Antiproliferative activity against PC3 cells by colorimetric MTT assay | ChEMBL. | 17827015 |
IC50 (functional) | > 100 uM | Antiproliferative activity against MCF7 cells by colorimetric MTT assay | ChEMBL. | 17827015 |
IC50 (functional) | > 100 uM | Antiproliferative activity against DU145 cells by colorimetric MTT assay | ChEMBL. | 17827015 |
IC50 (functional) | > 100 uM | Antiproliferative activity against PC3 cells by colorimetric MTT assay | ChEMBL. | 17827015 |
IC50 (functional) | > 100 uM | Antiproliferative activity against MCF7 cells by colorimetric MTT assay | ChEMBL. | 17827015 |
Inhibition (functional) | = 41 % | Antiproliferative activity against L1210 cells by colorimetric MTT assay at 10 uM | ChEMBL. | 17827015 |
Inhibition (functional) | = 41 % | Antiproliferative activity against L1210 cells by colorimetric MTT assay at 10 uM | ChEMBL. | 17827015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.