Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Chalcone synthase Pks11 | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 335 aa | 294 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0383 | 0.9488 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0098 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0098 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0098 | 0 | 0.5 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0383 | 0.9488 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0098 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0098 | 0 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0098 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 0.9488 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0383 | 0.9488 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0098 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0098 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0098 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0098 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0098 | 0 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0383 | 0.9488 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0098 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0098 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0098 | 0 | 0.5 |
Onchocerca volvulus | 0.0098 | 0 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0098 | 0 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0383 | 0.9488 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0098 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0383 | 0.9488 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0098 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 0.9488 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0098 | 0 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0098 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0098 | 0 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0098 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0098 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0098 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0098 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0098 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.