Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0497 | 0.239 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.0935 | 0.5 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.1801 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.0935 | 0.3915 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0497 | 0.239 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Schistosoma mansoni | carbonic anhydrase | 0.0134 | 0.0272 | 0.0624 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.0935 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0497 | 0.239 | 1 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.1801 | 1 | 0.5 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0497 | 0.239 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.0272 | 0.0624 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | apoptosis regulator bax | 0.0497 | 0.239 | 0.5482 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.239 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0935 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.0935 | 0.3915 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.0935 | 0.3915 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.0935 | 0.3915 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0935 | 0.5 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.0935 | 0.3915 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0088 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.1801 | 1 | 0.5 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.0935 | 0.3915 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.0272 | 0.1138 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0497 | 0.239 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0935 | 0.2146 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.1801 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0834 | 0.4359 | 1 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.1801 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0134 | 0.0272 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0134 | 0.0272 | 0.5 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0935 | 0.2146 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.0272 | 0.1138 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0497 | 0.239 | 1 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0497 | 0.239 | 0.5482 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0088 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 20 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 20 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 35 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 35 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 240 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Ki (binding) | = 240 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.