Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IV | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0935 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.1801 | 1 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.0935 | 0.5 |
Schistosoma mansoni | apoptosis regulator bax | 0.0497 | 0.239 | 0.5482 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.0935 | 0.3915 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0497 | 0.239 | 0.5482 |
Schistosoma mansoni | carbonic anhydrase | 0.0134 | 0.0272 | 0.0624 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.0272 | 0.0624 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.0935 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0935 | 0.2146 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.0935 | 0.3915 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.0272 | 0.1138 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0497 | 0.239 | 1 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.1801 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0834 | 0.4359 | 1 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0088 | 0 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.0935 | 0.2146 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0497 | 0.239 | 1 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0497 | 0.239 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.0935 | 0.3915 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0088 | 0 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.0935 | 0.3915 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.1801 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0497 | 0.239 | 1 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Plasmodium falciparum | carbonic anhydrase | 0.0134 | 0.0272 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.1801 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0134 | 0.0272 | 0.0624 |
Schistosoma mansoni | hypothetical protein | 0.0497 | 0.239 | 0.5482 |
Toxoplasma gondii | hypothetical protein | 0.0134 | 0.0272 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0935 | 0.5 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0272 | 0.1138 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.1801 | 1 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.0935 | 0.3915 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0497 | 0.239 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0134 | 0.0272 | 0.1138 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0497 | 0.239 | 1 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0134 | 0.0272 | 0.1138 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0497 | 0.239 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.0935 | 0.3915 |
Onchocerca volvulus | 0.0088 | 0 | 0.5 | |
Onchocerca volvulus | 0.0088 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 13 nM | Inhibition of cloned isozyme, human carbonic anhydrase II | ChEMBL. | 11229775 |
Ki (binding) | = 13 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 13 nM | Inhibition of cloned isozyme, human carbonic anhydrase II | ChEMBL. | 11229775 |
Ki (binding) | = 13 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 29 nM | Inhibition of cloned isozyme, human carbonic anhydrase IV | ChEMBL. | 11229775 |
Ki (binding) | = 29 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 29 nM | Inhibition of cloned isozyme, human carbonic anhydrase IV | ChEMBL. | 11229775 |
Ki (binding) | = 29 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 180 nM | Inhibition of cloned isozyme, human carbonic anhydrase I | ChEMBL. | 11229775 |
Ki (binding) | = 180 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Ki (binding) | = 180 nM | Inhibition of cloned isozyme, human carbonic anhydrase I | ChEMBL. | 11229775 |
Ki (binding) | = 180 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.