Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Dopamine receptor | 475 aa | 398 aa | 34.2 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine receptor | 475 aa | 405 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.0219 | 1 | 0.5 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0219 | 1 | 1 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.0219 | 1 | 0.5 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.0219 | 1 | 0.5 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0219 | 1 | 0.5 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0114 | 0 | 0.5 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.0219 | 1 | 0.5 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0219 | 1 | 0.5 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.0219 | 1 | 0.5 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0219 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.2786 | 0.7917 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.0219 | 1 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0144 | 0.2786 | 0.2786 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0219 | 1 | 1 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0219 | 1 | 0.5 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0219 | 1 | 1 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0151 | 0.3519 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.0219 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.0219 | 1 | 0.5 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0144 | 0.2786 | 0.2786 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0144 | 0.2786 | 0.7917 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0114 | 0 | 0.5 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0219 | 1 | 1 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0144 | 0.2786 | 0.7917 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0219 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0219 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0219 | 1 | 1 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0219 | 1 | 0.5 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0151 | 0.3519 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0219 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.