Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4A, cAMP-specific | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.091 | 1 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0375 | 0.3294 | 0.3294 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.3294 | 0.3294 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0427 | 0.3949 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0375 | 0.3294 | 0.3294 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0375 | 0.3294 | 0.3294 |
Echinococcus multilocularis | protein patched | 0.0375 | 0.3294 | 0.3294 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.091 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.091 | 1 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0375 | 0.3294 | 0.3294 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.091 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0427 | 0.3949 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.091 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.091 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0375 | 0.3294 | 0.3294 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0427 | 0.3949 | 1 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0112 | 0 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.091 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.091 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0375 | 0.3294 | 0.3294 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0427 | 0.3949 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0375 | 0.3294 | 0.3294 |
Schistosoma mansoni | patched 1 | 0.0375 | 0.3294 | 0.3294 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.091 | 1 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0375 | 0.3294 | 0.3294 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.