Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1654 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1714 | 0.0983 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0149 | 0.1654 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1654 | 0.0917 |
Loa Loa (eye worm) | POT family protein | 0.0308 | 0.4395 | 0.39 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0633 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0101 | 0.0843 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1714 | 0.0983 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0201 | 0.2557 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1654 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.2557 | 0.19 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0101 | 0.0843 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1714 | 0.0983 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1995 | 0.7801 |
Toxoplasma gondii | peptidase family M13 protein | 0.0201 | 0.2557 | 0.5 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0201 | 0.2557 | 0.5 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0201 | 0.2557 | 0.5 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0201 | 0.2557 | 0.5 |
Brugia malayi | POT family protein | 0.0308 | 0.4395 | 0.2469 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.2557 | 0.19 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0201 | 0.2557 | 1 |
Onchocerca volvulus | 0.01 | 0.0811 | 0.5 | |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0149 | 0.1654 | 0.0917 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1995 | 0.7801 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.2557 | 0.19 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1654 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1714 | 0.0983 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0101 | 0.0843 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1714 | 0.0983 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0101 | 0.0843 | 0.3296 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0201 | 0.2557 | 1 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0101 | 0.0843 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1714 | 0.0983 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 64 uM | Inhibitory activity of the compound against proliferation of human epidermoid carcinoma (A431) cells | ChEMBL. | 12031320 |
IC50 (functional) | = 64 uM | Inhibitory activity of the compound against proliferation of human epidermoid carcinoma (A431) cells | ChEMBL. | 12031320 |
IC50 (functional) | = 74 uM | Inhibitory activity of the compound against proliferation of murine leukemia (L1210) cells | ChEMBL. | 12031320 |
IC50 (functional) | = 74 uM | Inhibitory activity of the compound against proliferation of murine leukemia (L1210) cells | ChEMBL. | 12031320 |
Inhibition (functional) | = 60 % | Anti-angiogenic activity wasassessed by inhibition of the vascular growth in the chick embryo chorioallantoic membrane (CAM assay) at 125 nM | ChEMBL. | 12031320 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.