Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.0214 | 0.4575 | 0.4575 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.4575 | 0.5742 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 0.4575 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0214 | 0.4575 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.4575 | 0.5742 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.4575 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0349 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0.4575 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0101 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0299 | 0.7968 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0274 | 0.6977 | 0.6977 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0274 | 0.6977 | 0.6977 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0214 | 0.4575 | 0.4575 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.4575 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 0.4575 | 1 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0261 | 0.6469 | 0.6469 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0.4575 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0101 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0261 | 0.6469 | 0.6469 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 0.4575 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 38 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 38 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 150 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 150 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 335 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Ki (binding) | = 335 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.