Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase domain 17 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | ADAM17 peptidase (M12 family) | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma japonicum | ko:K06059 a disintegrin and metalloproteinase domain 17, putative | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Brugia malayi | Disintegrin family protein | ADAM metallopeptidase domain 17 | 824 aa | 724 aa | 27.4 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.1959 | 0.4026 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0845 | 0.1972 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.3055 | 0.244 |
Mycobacterium ulcerans | hydrolase | 0.009 | 0.1187 | 0.5 |
Echinococcus granulosus | geminin | 0.0174 | 0.3159 | 0.5923 |
Brugia malayi | Matrixin family protein | 0.0074 | 0.0813 | 0.1671 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.009 | 0.1187 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0178 | 0.3245 | 0.6669 |
Onchocerca volvulus | 0.0137 | 0.2293 | 0.3651 | |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.014 | 0.2353 | 0.4413 |
Brugia malayi | bZIP transcription factor family protein | 0.0175 | 0.3166 | 0.6507 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0845 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.3159 | 0.737 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.1959 | 0.1247 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0845 | 0.5 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0223 | 0.4286 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.2404 | 0.5609 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0105 | 0.1548 | 0.3182 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0075 | 0.0845 | 0.1972 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0074 | 0.0813 | 0.1897 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0105 | 0.1548 | 0.2902 |
Echinococcus multilocularis | jun protein | 0.0175 | 0.3166 | 0.5937 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0268 | 0.5333 | 1 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.4286 | 0.8036 |
Brugia malayi | Matrixin family protein | 0.0074 | 0.0813 | 0.1671 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.4803 | 0.9006 |
Brugia malayi | Pax transcription factor protein 2 | 0.0248 | 0.4866 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.3159 | 0.737 |
Brugia malayi | hypothetical protein | 0.0137 | 0.2293 | 0.4712 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1187 | 0.0407 |
Brugia malayi | Matrixin family protein | 0.0074 | 0.0813 | 0.1671 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0175 | 0.3166 | 0.5937 |
Loa Loa (eye worm) | matrixin family protein | 0.0178 | 0.3245 | 0.2647 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0175 | 0.3166 | 0.5937 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0075 | 0.0845 | 0.1584 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0845 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0163 | 0.2902 | 0.5154 |
Echinococcus granulosus | jun protein | 0.0175 | 0.3166 | 0.5937 |
Onchocerca volvulus | 0.0104 | 0.153 | 0.1769 | |
Echinococcus multilocularis | geminin | 0.0174 | 0.3159 | 0.5923 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0075 | 0.0845 | 0.1584 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0248 | 0.4866 | 0.4411 |
Brugia malayi | hypothetical protein | 0.0075 | 0.0845 | 0.1737 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0105 | 0.1548 | 0.3612 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0845 | 0.5 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0105 | 0.1548 | 0.2902 |
Schistosoma mansoni | jun-related protein | 0.0142 | 0.2404 | 0.5609 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.153 | 0.3569 |
Onchocerca volvulus | 0.0248 | 0.4866 | 1 | |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.009 | 0.1187 | 0.2439 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.014 | 0.2353 | 0.4413 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.009 | 0.1187 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0163 | 0.2902 | 0.2274 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0163 | 0.2902 | 0.5154 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.005 | 0.0262 | 0.0611 |
Brugia malayi | Matrixin family protein | 0.0074 | 0.0813 | 0.1671 |
Brugia malayi | Hemopexin family protein | 0.0104 | 0.153 | 0.3144 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0268 | 0.5333 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.1959 | 0.1247 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.99 | Inhibition of MMP1 (unknown origin) | ChEMBL. | 17275314 |
IC50 (binding) | = 1 nM | Inhibitory activity against matrix metalloproteinase 9 (MMP-9). | ChEMBL. | 12668018 |
IC50 (binding) | = 1 nM | Inhibitory activity against matrix metalloproteinase 13 (MMP-13). | ChEMBL. | 12668018 |
IC50 (binding) | = 1 nM | Inhibitory activity against matrix metalloproteinase 9 (MMP-9). | ChEMBL. | 12668018 |
IC50 (binding) | = 1 nM | Inhibitory activity against matrix metalloproteinase 13 (MMP-13). | ChEMBL. | 12668018 |
IC50 (binding) | = 124 nM | Inhibitory activity against TACE. | ChEMBL. | 12668018 |
IC50 (binding) | = 124 nM | Inhibitory activity against TACE. | ChEMBL. | 12668018 |
IC50 (binding) | = 1012 nM | Inhibitory activity against matrix metalloproteinase 1 (MMP-1). | ChEMBL. | 12668018 |
IC50 (binding) | = 1012 nM | Inhibitory activity against matrix metalloproteinase 1 (MMP-1). | ChEMBL. | 12668018 |
Inhibition (functional) | = 42 % | Ex vivo inhibition of cartilage degradation at 100 nM concentration in the bovine articular cartilage explant assay | ChEMBL. | 12668018 |
Inhibition (functional) | = 44 % | In vivo inhibition of cartilage degradation at 50 mpk po bid in the rat sponge-wrapped cartilage implant model | ChEMBL. | 12668018 |
Inhibition (functional) | = 90 % | In vivo inhibition of MMP-13 at 50 mpk po 1 h after dosing in the mouse dialysis tubing implant assay | ChEMBL. | 12668018 |
Inhibition (functional) | = 90 % | In vivo inhibition of MMP-13 at 50 mpk po 1 h after dosing in the mouse dialysis tubing implant assay | ChEMBL. | 12668018 |
log(1/IC50) (binding) | = 5.99 | Inhibition of MMP1 (unknown origin) | ChEMBL. | 17275314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.