Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0214 | 0.4575 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 0.4575 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.4575 | 0.5742 |
Echinococcus granulosus | carbonic anhydrase II | 0.0214 | 0.4575 | 0.4575 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0299 | 0.7968 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0.4575 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0101 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0349 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.4575 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.4575 | 0.5742 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0261 | 0.6469 | 0.6469 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 0.4575 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0274 | 0.6977 | 0.6977 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.4575 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0214 | 0.4575 | 0.4575 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0274 | 0.6977 | 0.6977 |
Plasmodium falciparum | carbonic anhydrase | 0.0101 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0261 | 0.6469 | 0.6469 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 0.4575 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0.4575 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 72 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 72 nm | Inhibitory activity against Human carbonic anhydrase II | ChEMBL. | 11906288 |
Ki (binding) | = 250 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 250 nm | Inhibitory activity against bovine carbonic anhydrase IV | ChEMBL. | 11906288 |
Ki (binding) | = 500 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Ki (binding) | = 500 nm | Inhibitory activity against Human carbonic anhydrase I | ChEMBL. | 11906288 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.