Detailed information for compound 49864

Basic information

Technical information
  • TDR Targets ID: 49864
  • Name: 2-(hydroxymethyl)-5-(7-methoxytriazolo[4,5-d] pyrimidin-3-yl)oxolane-3,4-diol
  • MW: 283.241 | Formula: C10H13N5O5
  • H donors: 3 H acceptors: 7 LogP: -1.58 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1O)O)n1nnc2c1ncnc2OC
  • InChi: 1S/C10H13N5O5/c1-19-9-5-8(11-3-12-9)15(14-13-5)10-7(18)6(17)4(2-16)20-10/h3-4,6-7,10,16-18H,2H2,1H3
  • InChiKey: KAJPRVFYQRAZFP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(hydroxymethyl)-5-(7-methoxytriazolo[4,5-d]pyrimidin-3-yl)tetrahydrofuran-3,4-diol
  • 2-(hydroxymethyl)-5-(7-methoxy-3-triazolo[4,5-d]pyrimidinyl)tetrahydrofuran-3,4-diol
  • 2-(hydroxymethyl)-5-(7-methoxy-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)oxolane-3,4-diol
  • 2-(7-methoxytriazolo[4,5-d]pyrimidin-3-yl)-5-methylol-tetrahydrofuran-3,4-diol
  • 2-(hydroxymethyl)-5-(7-methoxytriazolo[4,5-e]pyrimidin-3-yl)oxolane-3,4-diol
  • 2-(hydroxymethyl)-5-(7-methoxytriazolo[4,5-e]pyrimidin-3-yl)tetrahydrofuran-3,4-diol
  • 2-(hydroxymethyl)-5-(7-methoxy-3-triazolo[4,5-e]pyrimidinyl)tetrahydrofuran-3,4-diol
  • 2-(7-methoxytriazolo[4,5-e]pyrimidin-3-yl)-5-methylol-tetrahydrofuran-3,4-diol
  • 2-(hydroxymethyl)-5-(7-methoxy-[1,2,3]triazolo[4,5-e]pyrimidin-3-yl)oxolane-3,4-diol
  • 38874-43-0
  • NSC307994
  • 3H-1,2,3-Triazolo[4,5-d]pyrimidine, 7-methoxy-3-.beta.-D-ribofuranosyl-
  • NSC170309

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0305 0.7261 1
Brugia malayi hypothetical protein 0.0305 0.7261 0.7261
Mycobacterium ulcerans beta-lactamase 0.0035 0 0.5
Schistosoma mansoni adenoreceptor 0.0305 0.7261 0.7261
Echinococcus granulosus neuropeptide receptor 0.0305 0.7261 0.8152
Echinococcus granulosus g protein coupled receptor 0.0305 0.7261 0.8152
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0141 0.0159
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.7261 0.7261
Echinococcus granulosus g-protein coupled receptor 0.0305 0.7261 0.8152
Schistosoma mansoni hypothetical protein 0.0305 0.7261 0.7261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.7261 0.7261
Echinococcus granulosus tubulin beta 4A class IVa 0.0242 0.5575 0.6259
Echinococcus multilocularis G protein coupled receptor 139 0.0305 0.7261 0.8152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Echinococcus granulosus Tubulin beta 2C chain 0.0242 0.5575 0.6259
Schistosoma mansoni hypothetical protein 0.0305 0.7261 0.7261
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0041 0.0141 0.0159
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Brugia malayi Serotonin receptor 0.0305 0.7261 0.7261
Brugia malayi G protein-coupled receptor F59B2.13 0.0305 0.7261 0.7261
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0305 0.7261 0.8152
Echinococcus granulosus tm gpcr rhodopsin 0.0305 0.7261 0.8152
Loa Loa (eye worm) hypothetical protein 0.0041 0.0141 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0141 0.0253
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0305 0.7261 0.7261
Echinococcus multilocularis g protein coupled receptor 0.0305 0.7261 0.8152
Schistosoma mansoni biogenic amine receptor 0.0305 0.7261 0.7261
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0305 0.7261 0.7261
Echinococcus multilocularis neuropeptide FF receptor 2 0.0305 0.7261 0.8152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Loa Loa (eye worm) melatonin receptor type 1A 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Onchocerca volvulus 0.0305 0.7261 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0141 0.0141
Brugia malayi regulator of G-protein signaling rgs-7 0.0041 0.0141 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0141 0.0253
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Trichomonas vaginalis tubulin epsilon chain, putative 0.0242 0.5575 1
Onchocerca volvulus 0.0305 0.7261 1
Brugia malayi sulfakinin receptor protein 0.0305 0.7261 0.7261
Brugia malayi follicle stimulating hormone receptor 0.0305 0.7261 0.7261
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0305 0.7261 0.7261
Echinococcus multilocularis beta tubulin 0.0242 0.5575 0.6259
Brugia malayi G protein-coupled receptor 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Echinococcus granulosus tubulin subunit beta 0.0242 0.5575 0.6259
Brugia malayi putative neuropeptide receptor 0.0305 0.7261 0.7261
Brugia malayi Tubulin beta-1 chain 0.0242 0.5575 0.5575
Echinococcus granulosus orexin receptor type 2 0.0305 0.7261 0.8152
Echinococcus multilocularis Regulator of G protein signaling 20 0.0041 0.0141 0.0159
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0141 0.0159
Schistosoma mansoni myosin xvIII 0.0305 0.7261 0.7261
Echinococcus multilocularis expressed protein 0.0041 0.0141 0.0159
Echinococcus granulosus biogenic amine 5HT receptor 0.0305 0.7261 0.8152
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0406 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0305 0.7261 0.7261
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0305 0.7261 0.8152
Echinococcus granulosus neuropeptide receptor 0.0305 0.7261 0.8152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Mycobacterium leprae Probable lipase LipE 0.0035 0 0.5
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0041 0.0141 0.0253
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0305 0.7261 0.7261
Onchocerca volvulus 0.0305 0.7261 1
Brugia malayi hypothetical protein 0.0305 0.7261 0.7261
Echinococcus multilocularis g protein coupled receptor 0.0305 0.7261 0.8152
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0305 0.7261 0.7261
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0141 0.0159
Echinococcus granulosus 7TM GPCR rhodopsin 0.0305 0.7261 0.8152
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0305 0.7261 0.7261
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Plasmodium falciparum tubulin beta chain 0.0242 0.5575 0.5
Brugia malayi AKH receptor 0.0305 0.7261 0.7261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.7261 0.7261
Leishmania major beta tubulin 0.0242 0.5575 1
Onchocerca volvulus 0.0305 0.7261 1
Echinococcus multilocularis neuropeptide receptor A26 0.0305 0.7261 0.8152
Brugia malayi hypothetical protein 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0305 0.7261 0.8152
Trypanosoma brucei beta tubulin 0.0242 0.5575 1
Schistosoma mansoni tubulin subunit beta 0.0242 0.5575 0.5575
Echinococcus granulosus neuropeptide s receptor 0.0305 0.7261 0.8152
Schistosoma mansoni biogenic amine receptor 0.0305 0.7261 0.7261
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0242 0.5575 0.6259
Onchocerca volvulus 0.0305 0.7261 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0305 0.7261 0.7261
Echinococcus multilocularis fmrfamide receptor 0.0305 0.7261 0.8152
Schistosoma mansoni regulator of G protein signaling 0.0049 0.0376 0.0376
Schistosoma mansoni neuropeptide f receptor 76f 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Trichomonas vaginalis tubulin gamma chain, putative 0.0242 0.5575 1
Echinococcus granulosus Tubulin beta 2C chain 0.0242 0.5575 0.6259
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Echinococcus multilocularis sex peptide receptor 0.0305 0.7261 0.8152
Loa Loa (eye worm) tubulin beta-2A chain 0.0242 0.5575 0.5575
Schistosoma mansoni amine GPCR 0.0305 0.7261 0.7261
Echinococcus multilocularis Tubulin beta 2C chain 0.0242 0.5575 0.6259
Echinococcus multilocularis tubulin subunit beta 0.0242 0.5575 0.6259
Brugia malayi Dopamine receptor 0.0305 0.7261 0.7261
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0 0.5
Echinococcus multilocularis orexin receptor type 2 0.0305 0.7261 0.8152
Leishmania major beta tubulin 0.0242 0.5575 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0305 0.7261 0.7261
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0168 0.0168
Schistosoma mansoni tubulin subunit beta 0.0242 0.5575 0.5575
Brugia malayi Melatonin receptor type 1A 0.0305 0.7261 0.7261
Echinococcus multilocularis g-protein coupled receptor 0.0305 0.7261 0.8152
Echinococcus granulosus tachykinin peptides receptor 99D 0.0305 0.7261 0.8152
Trypanosoma brucei beta tubulin 0.0242 0.5575 1
Leishmania major beta tubulin 0.0242 0.5575 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0141 0.0141
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0042 0.0168 0.0168
Leishmania major beta tubulin 0.0242 0.5575 1
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0366 0.8908 1
Brugia malayi hypothetical protein 0.0305 0.7261 0.7261
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.3818 0.5258
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Brugia malayi Serotonin receptor 0.0305 0.7261 0.7261
Loa Loa (eye worm) tubulin beta chain 0.0242 0.5575 0.5575
Loa Loa (eye worm) hypothetical protein 0.0041 0.0141 0.0141
Leishmania major beta tubulin 0.0242 0.5575 1
Brugia malayi PXA domain containing protein 0.0041 0.0141 0.0141
Toxoplasma gondii beta-1 tubulin, putative 0.0242 0.5575 1
Loa Loa (eye worm) G-protein coupled receptor 0.0305 0.7261 0.7261
Echinococcus granulosus dro:myosuppressin receptor 0.0305 0.7261 0.8152
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Trichomonas vaginalis tubulin, putative 0.0242 0.5575 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Toxoplasma gondii beta-tubulin, putative 0.0242 0.5575 1
Echinococcus granulosus neuropeptide Y receptor 0.0305 0.7261 0.8152
Brugia malayi hypothetical protein 0.0305 0.7261 0.7261
Echinococcus multilocularis neuropeptide s receptor 0.0305 0.7261 0.8152
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0305 0.7261 0.8152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Onchocerca volvulus 0.0305 0.7261 1
Echinococcus multilocularis neuropeptide Y receptor 0.0305 0.7261 0.8152
Echinococcus granulosus somatostatin receptor 0.0305 0.7261 0.8152
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0141 0.0253
Schistosoma mansoni tubulin subunit beta 0.0242 0.5575 0.5575
Brugia malayi hypothetical protein 0.0041 0.0141 0.0141
Echinococcus multilocularis G-protein coupled receptor, putative 0.0305 0.7261 0.8152
Schistosoma mansoni neuropeptide F-like receptor 0.0305 0.7261 0.7261
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0141 0.0141
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0141 0.0141
Echinococcus granulosus neuropeptide Y receptor 0.0305 0.7261 0.8152
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0141 0.0159
Schistosoma mansoni serine/threonine protein kinase 0.0406 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0305 0.7261 0.8152
Schistosoma mansoni amine GPCR 0.0305 0.7261 0.7261
Schistosoma mansoni growth hormone secretagogue receptor 0.0305 0.7261 0.7261
Trypanosoma brucei beta tubulin 0.0242 0.5575 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Brugia malayi G-protein coupled receptor 0.0305 0.7261 0.7261
Leishmania major beta tubulin 0.0242 0.5575 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0305 0.7261 0.7261
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0168 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.7261 0.7261
Schistosoma mansoni biogenic amine receptor 0.0305 0.7261 0.7261
Echinococcus multilocularis Tubulin beta 2C chain 0.0242 0.5575 0.6259
Schistosoma mansoni amine GPCR 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Leishmania major beta tubulin 0.0242 0.5575 1
Schistosoma mansoni histamine h1 receptor 0.0305 0.7261 0.7261
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Echinococcus granulosus regulator of G protein signaling 7 0.0049 0.0376 0.0422
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0366 0.8908 0.8908
Trichomonas vaginalis tubulin alpha chain, putative 0.0242 0.5575 1
Brugia malayi hypothetical protein 0.0305 0.7261 0.7261
Echinococcus granulosus tm gpcr rhodopsin 0.0305 0.7261 0.8152
Echinococcus multilocularis neuropeptides capa receptor 0.0305 0.7261 0.8152
Echinococcus granulosus tubulin beta 1 chain 0.0242 0.5575 0.6259
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0141 0.0159
Leishmania major beta tubulin 0.0242 0.5575 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Echinococcus granulosus g protein coupled receptor 0.0305 0.7261 0.8152
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.7261 0.7261
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0305 0.7261 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Onchocerca volvulus 0.0305 0.7261 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.3818 0.3818
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0041 0.0141 0.0141
Echinococcus multilocularis beta tubulin 0.0242 0.5575 0.6259
Loa Loa (eye worm) TYRA-2 protein 0.0305 0.7261 0.7261
Toxoplasma gondii beta tubulin 0.0242 0.5575 1
Echinococcus granulosus tm gpcr rhodopsin 0.0305 0.7261 0.8152
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0305 0.7261 0.8152
Echinococcus multilocularis allatostatin A receptor 0.0305 0.7261 0.8152
Onchocerca volvulus 0.0305 0.7261 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.7261 0.7261
Schistosoma mansoni amine GPCR 0.0305 0.7261 0.7261
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0305 0.7261 0.8152
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0305 0.7261 0.8152
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Echinococcus multilocularis g protein coupled receptor 0.0305 0.7261 0.8152
Loa Loa (eye worm) hypothetical protein 0.0041 0.0141 0.0141
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Schistosoma mansoni opsin-like receptor 0.0305 0.7261 0.7261
Echinococcus multilocularis Tubulin beta 2C chain 0.0242 0.5575 0.6259
Leishmania major beta tubulin 0.0242 0.5575 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Leishmania major beta tubulin 0.0242 0.5575 1
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0141 0.0141
Schistosoma mansoni tubulin subunit beta 0.0242 0.5575 0.5575
Brugia malayi G-protein coupled receptor 0.0305 0.7261 0.7261
Echinococcus granulosus peptide allatostatin:somatostatin 0.0305 0.7261 0.8152
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0305 0.7261 0.7261
Loa Loa (eye worm) neuropeptide F receptor 0.0305 0.7261 0.7261
Echinococcus granulosus biogenic amine 5HT receptor 0.0305 0.7261 0.8152
Echinococcus multilocularis Tubulin beta 2C chain 0.0242 0.5575 0.6259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0305 0.7261 0.8152
Brugia malayi PXA domain containing protein 0.0041 0.0141 0.0141
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0305 0.7261 0.8152
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0305 0.7261 0.8152
Loa Loa (eye worm) hypothetical protein 0.0041 0.0141 0.0141
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0305 0.7261 0.8152
Brugia malayi putative neuropeptide receptor NPR1 0.0305 0.7261 0.7261
Echinococcus granulosus G protein coupled receptor 139 0.0305 0.7261 0.8152
Brugia malayi A-kinase anchor protein 10, precursor 0.0041 0.0141 0.0141
Loa Loa (eye worm) tubulin beta-4 chain 0.0242 0.5575 0.5575
Brugia malayi hypothetical protein 0.0305 0.7261 0.7261
Brugia malayi Dopamine receptor protein 2 0.0305 0.7261 0.7261
Loa Loa (eye worm) BEN-1 protein 0.0242 0.5575 0.5575
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0305 0.7261 0.7261
Schistosoma mansoni neuropeptide receptor 0.0305 0.7261 0.7261
Echinococcus multilocularis serotonin receptor 0.0305 0.7261 0.8152
Loa Loa (eye worm) PXA domain-containing protein 0.0041 0.0141 0.0141
Leishmania major beta tubulin 0.0242 0.5575 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0366 0.8908 0.8908
Echinococcus multilocularis regulator of G protein signaling 7 0.0049 0.0376 0.0422
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0305 0.7261 0.7261
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0366 0.8908 0.8908
Brugia malayi GnHR receptor homolog 0.0305 0.7261 0.7261
Mycobacterium leprae conserved hypothetical protein 0.0035 0 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Giardia lamblia Beta tubulin 0.0242 0.5575 0.5
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0049 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Echinococcus granulosus fmrfamide receptor 0.0305 0.7261 0.8152
Echinococcus granulosus expressed protein 0.0041 0.0141 0.0159
Onchocerca volvulus 0.0305 0.7261 1
Echinococcus granulosus Tubulin beta 2C chain 0.0242 0.5575 0.6259
Leishmania major beta tubulin 0.0242 0.5575 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Echinococcus granulosus alpha 1A adrenergic receptor 0.0305 0.7261 0.8152
Schistosoma mansoni opsin-like receptor 0.0305 0.7261 0.7261
Onchocerca volvulus 0.0305 0.7261 1
Onchocerca volvulus 0.0305 0.7261 1
Leishmania major beta tubulin 0.0242 0.5575 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0305 0.7261 0.7261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Schistosoma mansoni neuropeptide F-like receptor 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Loa Loa (eye worm) RGS-3 protein 0.0041 0.0141 0.0141
Brugia malayi ORL1-like opioid receptor 0.0305 0.7261 0.7261
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0305 0.7261 0.8152
Echinococcus multilocularis beta adrenergic receptor kinase 0.0042 0.0168 0.0188
Echinococcus multilocularis serotonin receptor 0.0305 0.7261 0.8152
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Leishmania major beta tubulin 0.0242 0.5575 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Brugia malayi regulator of G-protein signaling egl-10 0.0049 0.0376 0.0376
Entamoeba histolytica tubulin family protein 0.0242 0.5575 1
Schistosoma mansoni tubulin subunit beta 0.0242 0.5575 0.5575
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0305 0.7261 0.7261
Echinococcus multilocularis neuropeptide receptor 0.0305 0.7261 0.8152
Schistosoma mansoni z-protein (S1r protein) 0.0049 0.0376 0.0376
Brugia malayi hypothetical protein 0.0305 0.7261 0.7261
Echinococcus granulosus beta-adrenergic receptor kinase 0.0042 0.0168 0.0188
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0141 0.0141
Echinococcus granulosus Tubulin beta 2C chain 0.0242 0.5575 0.6259
Loa Loa (eye worm) hypothetical protein 0.0049 0.0376 0.0376
Schistosoma mansoni biogenic amine (5HT) receptor 0.0305 0.7261 0.7261
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0366 0.8908 1
Echinococcus granulosus beta tubulin 0.0242 0.5575 0.6259
Echinococcus granulosus g protein coupled receptor 0.0305 0.7261 0.8152
Brugia malayi hypothetical protein 0.0305 0.7261 0.7261
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.5126 1
Mycobacterium ulcerans lipase LipD 0.0035 0 0.5
Leishmania major beta tubulin 0.0242 0.5575 1
Onchocerca volvulus 0.0305 0.7261 1
Schistosoma mansoni hypothetical protein 0.0305 0.7261 0.7261
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0141 0.0159
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Schistosoma mansoni hypothetical protein 0.0305 0.7261 0.7261
Brugia malayi hypothetical protein 0.0041 0.0141 0.0141
Echinococcus multilocularis neuropeptide Y receptor 0.0305 0.7261 0.8152
Echinococcus multilocularis dro:myosuppressin receptor 0.0305 0.7261 0.8152
Loa Loa (eye worm) G-protein coupled receptor 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Trichomonas vaginalis tubulin epsilon chain, putative 0.0242 0.5575 1
Plasmodium vivax tubulin beta chain, putative 0.0242 0.5575 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.7261 0.7261
Echinococcus granulosus 7tm_1 domain containing protein 0.0305 0.7261 0.8152
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0305 0.7261 0.8152
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Echinococcus granulosus serotonin receptor 0.0305 0.7261 0.8152
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0305 0.7261 0.8152
Brugia malayi hypothetical protein 0.0305 0.7261 0.7261
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0141 0.0253
Schistosoma mansoni tubulin subunit beta 0.0242 0.5575 0.5575
Echinococcus multilocularis regulator of G protein signaling 0.0041 0.0141 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0141 0.0253
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0141 0.0159
Schistosoma mansoni neuropeptide receptor 0.0305 0.7261 0.7261
Schistosoma mansoni neuropeptide receptor 0.0305 0.7261 0.7261
Trypanosoma cruzi beta tubulin, putative 0.0242 0.5575 1
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0141 0.0141
Echinococcus multilocularis neuropeptides capa receptor 0.0305 0.7261 0.8152
Echinococcus granulosus Regulator of G protein signaling 20 0.0041 0.0141 0.0159
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Mycobacterium ulcerans hypothetical protein 0.0035 0 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0305 0.7261 0.8152
Brugia malayi neuropeptide F receptor 0.0305 0.7261 0.7261
Echinococcus granulosus beta tubulin 0.0242 0.5575 0.6259
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Echinococcus multilocularis fmrfamide receptor 0.0305 0.7261 0.8152
Trichomonas vaginalis tubulin beta chain, putative 0.0242 0.5575 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Echinococcus granulosus hypothetical protein 0.0305 0.7261 0.8152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0305 0.7261 0.8152
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0305 0.7261 0.7261
Brugia malayi Dopamine receptor protein 1 0.0305 0.7261 0.7261
Onchocerca volvulus 0.0305 0.7261 1
Echinococcus granulosus Tubulin beta 2C chain 0.0242 0.5575 0.6259
Echinococcus granulosus neuropeptides capa receptor 0.0305 0.7261 0.8152
Echinococcus granulosus regulator of G protein signaling 7 0.0049 0.0376 0.0422
Echinococcus granulosus neuropeptide FF receptor 2 0.0305 0.7261 0.8152
Trypanosoma brucei beta tubulin 0.0242 0.5575 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0305 0.7261 0.8152
Loa Loa (eye worm) beta-tubulin 0.0242 0.5575 0.5575
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0141 0.0141
Brugia malayi N-terminal motif family protein 0.0177 0.3818 0.3818
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0305 0.7261 0.8152
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0305 0.7261 0.8152
Onchocerca volvulus Neuropeptide F receptor homolog 0.0305 0.7261 1
Echinococcus granulosus neuropeptides capa receptor 0.0305 0.7261 0.8152
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0305 0.7261 0.7261
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0305 0.7261 0.7261
Giardia lamblia Beta tubulin 0.0242 0.5575 0.5
Onchocerca volvulus 0.0305 0.7261 1
Echinococcus granulosus allatostatin A receptor 0.0305 0.7261 0.8152
Echinococcus multilocularis tubulin beta 1 chain 0.0242 0.5575 0.6259
Onchocerca volvulus 0.0305 0.7261 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0141 0.0253
Giardia lamblia Beta tubulin 0.0242 0.5575 0.5
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0041 0.0141 0.0159
Brugia malayi larval opioid receptor 0.0305 0.7261 0.7261
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0141 0.0141
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Brugia malayi beta-tubulin, identical 0.0242 0.5575 0.5575
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261
Leishmania major beta tubulin 0.0242 0.5575 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0305 0.7261 0.7261
Leishmania major beta tubulin 0.0242 0.5575 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0305 0.7261 0.7261
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0305 0.7261 0.7261
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0141 0.0159
Echinococcus multilocularis Tubulin beta 2C chain 0.0242 0.5575 0.6259
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0305 0.7261 0.8152
Brugia malayi RE15519p 0.0305 0.7261 0.7261
Brugia malayi neuropeptide F receptor 0.0305 0.7261 0.7261
Leishmania major beta tubulin 0.0242 0.5575 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0305 0.7261 0.7261
Loa Loa (eye worm) tubulin beta-1 chain 0.0242 0.5575 0.5575
Echinococcus multilocularis somatostatin receptor 0.0305 0.7261 0.8152
Echinococcus granulosus sex peptide receptor 0.0305 0.7261 0.8152
Schistosoma mansoni neuropeptide receptor 0.0305 0.7261 0.7261
Echinococcus multilocularis neuropeptide receptor 0.0305 0.7261 0.8152
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0305 0.7261 0.7261
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0305 0.7261 0.7261
Echinococcus granulosus rhodopsin orphan GPCR 0.0305 0.7261 0.8152
Echinococcus multilocularis regulator of G protein signaling 7 0.0049 0.0376 0.0422
Schistosoma mansoni amine GPCR 0.0305 0.7261 0.7261
Loa Loa (eye worm) hypothetical protein 0.0041 0.0141 0.0141
Schistosoma mansoni opsin-like receptor 0.0305 0.7261 0.7261
Onchocerca volvulus 0.0305 0.7261 1
Loa Loa (eye worm) BEN-1 protein 0.0242 0.5575 0.5575
Entamoeba histolytica tubulin family protein 0.0242 0.5575 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.7261 0.7261

Activities

Activity type Activity value Assay description Source Reference
Km (binding) = 140 uM Kinetic parameter in calf intestine adenosine deaminase. ChEMBL. 6620307
Vmax (ADMET) = 27 uM min-1 mg-1 Kinetic parameter of the compound in calf intestine adenosine deaminase. ChEMBL. 6620307

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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