Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0615 | 0.0545 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0251 | 0.2832 | 0.7905 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.0958 | 0.0957 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.0958 | 0.0957 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2832 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0056 | 0.0551 | 0.9658 |
Echinococcus multilocularis | geminin | 0.0863 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0615 | 0.0613 |
Onchocerca volvulus | 0.0147 | 0.1616 | 0.8697 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2832 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2832 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0.0557 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1822 | 0.5857 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0351 | 0.4005 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0074 | 0.0206 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.006 | 0.0598 | 0.0567 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0074 | 0.0072 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0615 | 0.1716 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0615 | 0.1713 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0615 | 0.0545 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0074 | 0.0072 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.0537 | 0.0397 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0537 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0074 | 0.0202 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0025 | 0.0182 | 0.0181 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0394 | 0.1099 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1822 | 0.5857 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0241 | 0.0169 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0462 | 0.1286 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0166 | 0.1839 | 0.4004 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0261 | 0.0259 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.0958 | 0.0891 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0055 | 0.0537 | 1 |
Onchocerca volvulus | 0.0043 | 0.0394 | 0.0966 | |
Onchocerca volvulus | 0.0043 | 0.0394 | 0.0966 | |
Leishmania major | mitochondrial DNA polymerase beta | 0.0351 | 0.4005 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.0958 | 0.2671 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1822 | 0.5857 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0615 | 0.0545 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0394 | 0.0392 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0049 | 0.0472 | 0.0217 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0166 | 0.1839 | 0.4004 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0615 | 0.1713 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.0958 | 0.0957 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2832 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1822 | 0.5857 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0394 | 0.1099 |
Schistosoma mansoni | hypothetical protein | 0.0863 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0615 | 0.0545 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0808 | 0.9361 | 0.9361 |
Schistosoma mansoni | hypothetical protein | 0.0863 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0351 | 0.4005 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0241 | 0.0669 |
Schistosoma mansoni | serine/threonine protein kinase | 0.032 | 0.3642 | 0.3595 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0394 | 0.1099 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0182 | 0.011 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0273 | 0.3086 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0185 | 0.2059 | 0.6186 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.0958 | 0.0891 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0394 | 0.1096 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0074 | 0.0072 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0241 | 0.0673 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0251 | 0.2832 | 0.7906 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0394 | 0.1099 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0049 | 0.0472 | 0.0217 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.0958 | 0.0891 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.1925 | 0.6282 |
Brugia malayi | Protein kinase domain containing protein | 0.0315 | 0.3582 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2832 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0261 | 0.0188 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0025 | 0.0182 | 0.0181 |
Onchocerca volvulus | 0.0043 | 0.0394 | 0.0966 | |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0074 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.3582 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1822 | 0.5857 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0282 | 0.021 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0074 | 0.0072 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0055 | 0.0537 | 0.8782 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.1925 | 0.6282 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0615 | 0.0545 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0049 | 0.0472 | 0.0217 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0462 | 0.1286 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0261 | 0.0259 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0074 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.3582 | 1 |
Brugia malayi | hypothetical protein | 0.0147 | 0.1616 | 0.451 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0394 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0282 | 0.0785 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1822 | 0.5857 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0074 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0394 | 0.1096 |
Mycobacterium ulcerans | hypothetical protein | 0.0185 | 0.2059 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0315 | 0.3582 | 0.3581 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0394 | 0.0322 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0394 | 0.5 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.0315 | 0.3582 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0394 | 0.1096 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0049 | 0.0472 | 0.0217 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0615 | 0.1716 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0282 | 0.0788 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.0537 | 0.5 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0615 | 0.1716 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0394 | 0.1096 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1822 | 0.5857 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0074 | 0.0202 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.0537 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0394 | 0.1096 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0055 | 0.0537 | 0.0397 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0615 | 0.0613 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0537 | 0.1499 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0315 | 0.3582 | 0.3581 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.0958 | 0.2674 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0261 | 0.0188 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0166 | 0.1839 | 0.4004 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0309 | 0.0863 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0351 | 0.4005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0394 | 0.1096 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0394 | 0.0392 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.2832 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.063 | 0.056 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0394 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0462 | 0.129 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0165 | 0.1822 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.0958 | 0.0957 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.0537 | 0.0397 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0615 | 0.1713 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1616 | 0.4508 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0537 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0394 | 0.1096 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0394 | 0.1096 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0462 | 0.129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative potency (functional) | = 0.53 | Ability to prevent the reserpine induced hypothermia in mice relative to amitriptyline | ChEMBL. | 7205881 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.