Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.0535 | 0.0397 |
Echinococcus multilocularis | phd:f box containing protein | 0.0019 | 0.0307 | 0.0307 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.013 | 0.603 | 1 |
Echinococcus granulosus | 6 phosphofructokinase | 0.013 | 0.603 | 0.603 |
Schistosoma mansoni | lamin | 0.0032 | 0.1002 | 0.1002 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0044 | 0.1612 | 0.1612 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0535 | 0.0535 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.0307 | 0.0307 |
Brugia malayi | phosphofructokinase | 0.013 | 0.603 | 0.603 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.013 | 0.603 | 0.603 |
Entamoeba histolytica | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.0307 | 0.0307 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3417 | 1 |
Onchocerca volvulus | 0.0068 | 0.2847 | 1 | |
Schistosoma mansoni | 6-phosphofructokinase | 0.013 | 0.603 | 0.603 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0307 | 0.0307 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.2525 | 0.2525 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0143 | 0.0143 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0044 | 0.1612 | 0.1612 |
Echinococcus granulosus | lamin | 0.0032 | 0.1002 | 0.1002 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0143 | 0.0143 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0208 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.1002 | 0.1002 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3417 | 0.5434 |
Trypanosoma brucei | cytochrome P450, putative | 0.0023 | 0.0535 | 0.0397 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0208 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0307 | 0.0307 |
Brugia malayi | jmjC domain containing protein | 0.007 | 0.2961 | 0.2961 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0143 | 0.0143 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0208 | 1 | 1 |
Echinococcus granulosus | phd:f box containing protein | 0.0019 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0535 | 0.0535 |
Leishmania major | cytochrome p450-like protein | 0.0023 | 0.0535 | 0.0397 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.013 | 0.603 | 0.5806 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0087 | 0.3805 | 0.3805 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.182 | 0.182 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.1002 | 0.1002 |
Schistosoma mansoni | jumonji domain containing protein | 0.007 | 0.2961 | 0.2961 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0307 | 0.0307 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0019 | 0.0307 | 0.0307 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.2961 | 0.2961 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.1002 | 0.1002 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0019 | 0.0307 | 0.0307 |
Echinococcus granulosus | dihydrofolate reductase | 0.0208 | 1 | 1 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0035 | 0.1149 | 0.2707 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.013 | 0.603 | 0.603 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1312 | 0.1312 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.007 | 0.2961 | 0.2961 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0231 | 0.0231 |
Echinococcus multilocularis | jun protein | 0.0087 | 0.3805 | 0.3805 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0023 | 0.0535 | 0.0535 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0035 | 0.1149 | 0.2707 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0019 | 0.0307 | 0.0307 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0019 | 0.0307 | 0.0307 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.1002 | 0.1002 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.1002 | 0.1002 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0019 | 0.0307 | 0.0307 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.182 | 0.182 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.1002 | 0.1002 |
Entamoeba histolytica | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0044 | 0.1612 | 0.1612 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0019 | 0.0307 | 0.0307 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.013 | 0.603 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.007 | 0.2961 | 0.2961 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3417 | 0.5434 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0113 | 0.0113 |
Echinococcus multilocularis | lamin | 0.0032 | 0.1002 | 0.1002 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0208 | 1 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.013 | 0.603 | 0.603 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0035 | 0.1149 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.0307 | 0.0307 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.013 | 0.603 | 1 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0019 | 0.0307 | 0.0307 |
Schistosoma mansoni | 6-phosphofructokinase | 0.013 | 0.603 | 0.603 |
Brugia malayi | bZIP transcription factor family protein | 0.0087 | 0.3805 | 0.3805 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1002 | 0.1002 |
Brugia malayi | jmjC domain containing protein | 0.007 | 0.2961 | 0.2961 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0971 | 0.0971 |
Entamoeba histolytica | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0019 | 0.0307 | 0.0307 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0535 | 0.0535 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3417 | 0.5434 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.0307 | 0.0307 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.2969 | 0.2969 |
Schistosoma mansoni | protein phosphatase 2C | 0.0019 | 0.0307 | 0.0307 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.0535 | 0.0397 |
Schistosoma mansoni | phd/f-box containing protein | 0.0019 | 0.0307 | 0.0307 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0079 | 0.3417 | 1 |
Schistosoma mansoni | lamin | 0.0032 | 0.1002 | 0.1002 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0208 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0019 | 0.0307 | 0.0307 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.007 | 0.2961 | 0.2961 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.007 | 0.2961 | 0.2961 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0535 | 0.0535 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0044 | 0.1612 | 0.1612 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0019 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.013 | 0.603 | 0.603 |
Echinococcus multilocularis | musashi | 0.0032 | 0.1002 | 0.1002 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0019 | 0.0307 | 0.0307 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0019 | 0.0307 | 0.0307 |
Leishmania major | ATP-dependent phosphofructokinase | 0.013 | 0.603 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.1002 | 0.1002 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.1463 | 0.0642 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0019 | 0.0307 | 0.0307 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.007 | 0.2961 | 0.2961 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3417 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.1002 | 0.1002 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0035 | 0.1149 | 0.2707 |
Schistosoma mansoni | jun-related protein | 0.0071 | 0.2969 | 0.2969 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.007 | 0.2961 | 0.2961 |
Brugia malayi | hypothetical protein | 0.0068 | 0.2847 | 0.2847 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.1463 | 0.0642 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0019 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0113 | 0.0113 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0087 | 0.3805 | 0.3805 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.013 | 0.603 | 0.603 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0035 | 0.1149 | 0.2707 |
Echinococcus granulosus | jun protein | 0.0087 | 0.3805 | 0.3805 |
Brugia malayi | 6-phosphofructokinase | 0.013 | 0.603 | 0.603 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0231 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3683 | 0.3683 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0035 | 0.1149 | 0.2707 |
Schistosoma mansoni | dihydrofolate reductase | 0.0208 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0208 | 1 | 1 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0035 | 0.1149 | 0.2707 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0035 | 0.1149 | 0.2707 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.032 uM | Activation of SMN2 promoter in mouse NSC34 cells assessed as induction of beta-lactamase activity | ChEMBL. | 18205293 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.