Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0021 | 0.0384 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0488 | 0.072 |
Onchocerca volvulus | 0.0024 | 0.0488 | 0.3853 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0143 | 0.402 | 0.5926 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0024 | 0.0488 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0488 | 0.072 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0355 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0024 | 0.0488 | 0.0488 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0488 | 0.0969 |
Schistosoma mansoni | gliotactin | 0.0024 | 0.0488 | 0.0969 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0355 | 0.0355 |
Schistosoma mansoni | rab6-interacting | 0.0021 | 0.0384 | 0.0761 |
Schistosoma mansoni | lipoxygenase | 0.0021 | 0.0384 | 0.0761 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0024 | 0.0488 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0058 | 0.1487 | 0.1487 |
Echinococcus multilocularis | tumor protein p63 | 0.0344 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0488 | 0.072 |
Echinococcus granulosus | geminin | 0.0177 | 0.5039 | 0.5039 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0024 | 0.0488 | 0.0969 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0355 | 0.0705 |
Echinococcus multilocularis | RUN | 0.0021 | 0.0384 | 0.0384 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0024 | 0.0488 | 0.0488 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0384 | 0.0761 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0355 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0488 | 0.0969 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0488 | 1 |
Echinococcus granulosus | RUN | 0.0021 | 0.0384 | 0.0384 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0384 | 0.0566 |
Loa Loa (eye worm) | carboxylesterase | 0.0143 | 0.402 | 0.5926 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0355 | 0.0705 |
Onchocerca volvulus | 0.0021 | 0.0384 | 0.3025 | |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0058 | 0.1487 | 0.1487 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0355 | 0.0524 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0024 | 0.0488 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0021 | 0.0384 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1268 | 0.1869 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0024 | 0.0488 | 0.0969 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0355 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0143 | 0.402 | 0.5926 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0384 | 0.0566 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0355 | 0.5 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0488 | 0.072 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.402 | 0.5926 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0143 | 0.402 | 0.7977 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0488 | 0.072 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0021 | 0.0384 | 0.0384 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0384 | 0.0566 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0355 | 0.0524 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0488 | 0.072 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0488 | 0.0969 |
Schistosoma mansoni | lipoxygenase | 0.0058 | 0.1487 | 0.2951 |
Brugia malayi | follicle stimulating hormone receptor | 0.0236 | 0.6782 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.1268 | 0.2516 |
Echinococcus granulosus | carboxylesterase 5A | 0.0143 | 0.402 | 0.402 |
Echinococcus multilocularis | acetylcholinesterase | 0.0143 | 0.402 | 0.402 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0355 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0021 | 0.0384 | 0.0384 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0488 | 0.072 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0024 | 0.0488 | 0.0488 |
Echinococcus multilocularis | acetylcholinesterase | 0.0143 | 0.402 | 0.402 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0024 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.402 | 0.5926 |
Schistosoma mansoni | rab6-interacting | 0.0021 | 0.0384 | 0.0761 |
Onchocerca volvulus | 0.0024 | 0.0488 | 0.3853 | |
Echinococcus multilocularis | geminin | 0.0177 | 0.5039 | 0.5039 |
Onchocerca volvulus | 0.0024 | 0.0488 | 0.3853 | |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0355 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0021 | 0.0384 | 0.0384 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0024 | 0.0488 | 0.0488 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0488 | 0.072 |
Onchocerca volvulus | 0.0021 | 0.0384 | 0.3025 | |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0355 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0488 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0488 | 0.072 |
Schistosoma mansoni | polycystin 1-related | 0.0021 | 0.0384 | 0.0761 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0355 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0384 | 0.0566 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0488 | 0.072 |
Onchocerca volvulus | 0.0024 | 0.0488 | 0.3853 | |
Echinococcus granulosus | acetylcholinesterase | 0.0143 | 0.402 | 0.402 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0021 | 0.0384 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0143 | 0.402 | 0.5926 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0024 | 0.0488 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0024 | 0.0488 | 0.0969 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0355 | 0.0355 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0143 | 0.402 | 0.402 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0488 | 0.072 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0488 | 0.072 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0021 | 0.0384 | 0.0384 |
Onchocerca volvulus | 0.005 | 0.1268 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5039 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0024 | 0.0488 | 0.0488 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0488 | 0.072 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0488 | 0.072 |
Brugia malayi | Doublecortin family protein | 0.0021 | 0.0384 | 0.0566 |
Onchocerca volvulus | 0.0024 | 0.0488 | 0.3853 | |
Echinococcus granulosus | acetylcholinesterase | 0.0143 | 0.402 | 0.402 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0236 | 0.6782 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0355 | 0.5 |
Schistosoma mansoni | loxhd1 | 0.0021 | 0.0384 | 0.0761 |
Echinococcus multilocularis | neuroligin | 0.0024 | 0.0488 | 0.0488 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0024 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | doublecortin family protein | 0.0021 | 0.0384 | 0.0566 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0021 | 0.0384 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.44 uM | Activation of SMN2 promoter in mouse NSC34 cells assessed as induction of beta-lactamase activity | ChEMBL. | 18205293 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.