Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.013 | 0.603 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.1002 | 0.1002 |
Schistosoma mansoni | lamin | 0.0032 | 0.1002 | 0.1002 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.007 | 0.2961 | 0.2961 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0019 | 0.0307 | 0.0307 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0019 | 0.0307 | 0.0307 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3417 | 0.5434 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.013 | 0.603 | 0.603 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0019 | 0.0307 | 0.0307 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0019 | 0.0307 | 0.0307 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3417 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0023 | 0.0535 | 0.0535 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0143 | 0.0143 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.1002 | 0.1002 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0019 | 0.0307 | 0.0307 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.182 | 0.182 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.1002 | 0.1002 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0535 | 0.0535 |
Entamoeba histolytica | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.1002 | 0.1002 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0231 | 0.0231 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.0535 | 0.0397 |
Leishmania major | cytochrome p450-like protein | 0.0023 | 0.0535 | 0.0397 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.013 | 0.603 | 1 |
Echinococcus granulosus | jun protein | 0.0087 | 0.3805 | 0.3805 |
Schistosoma mansoni | phd/f-box containing protein | 0.0019 | 0.0307 | 0.0307 |
Onchocerca volvulus | 0.0068 | 0.2847 | 1 | |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0035 | 0.1149 | 0.2707 |
Schistosoma mansoni | protein phosphatase 2C | 0.0019 | 0.0307 | 0.0307 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.1002 | 0.1002 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0143 | 0.0143 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0035 | 0.1149 | 0.2707 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3683 | 0.3683 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0535 | 0.0535 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.013 | 0.603 | 0.603 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0307 | 0.0307 |
Schistosoma mansoni | jumonji domain containing protein | 0.0019 | 0.0307 | 0.0307 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.007 | 0.2961 | 0.2961 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0035 | 0.1149 | 0.2707 |
Brugia malayi | jmjC domain containing protein | 0.007 | 0.2961 | 0.2961 |
Brugia malayi | jmjC domain containing protein | 0.007 | 0.2961 | 0.2961 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0035 | 0.1149 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.007 | 0.2961 | 0.2961 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.0307 | 0.0307 |
Echinococcus multilocularis | jun protein | 0.0087 | 0.3805 | 0.3805 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1002 | 0.1002 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.2961 | 0.2961 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0019 | 0.0307 | 0.0307 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0208 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0535 | 0.0535 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.0535 | 0.0397 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0019 | 0.0307 | 0.0307 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.1002 | 0.1002 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3417 | 0.5434 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0035 | 0.1149 | 0.2707 |
Echinococcus granulosus | 6 phosphofructokinase | 0.013 | 0.603 | 0.603 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3417 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.013 | 0.603 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3417 | 0.5434 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1312 | 0.1312 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0208 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.2525 | 0.2525 |
Schistosoma mansoni | jumonji domain containing protein | 0.007 | 0.2961 | 0.2961 |
Entamoeba histolytica | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0035 | 0.1149 | 0.2707 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.007 | 0.2961 | 0.2961 |
Brugia malayi | 6-phosphofructokinase | 0.013 | 0.603 | 0.603 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.1463 | 0.0642 |
Brugia malayi | hypothetical protein | 0.0068 | 0.2847 | 0.2847 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0044 | 0.1612 | 0.1612 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0044 | 0.1612 | 0.1612 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.1463 | 0.0642 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0019 | 0.0307 | 0.0307 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0208 | 1 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0143 | 0.0143 |
Brugia malayi | bZIP transcription factor family protein | 0.0087 | 0.3805 | 0.3805 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.0307 | 0.0307 |
Echinococcus multilocularis | phd:f box containing protein | 0.0019 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0113 | 0.0113 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.0307 | 0.0307 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0035 | 0.1149 | 0.2707 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.1002 | 0.1002 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0035 | 0.1149 | 0.2707 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0535 | 0.0535 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0079 | 0.3417 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.1002 | 0.1002 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0019 | 0.0307 | 0.0307 |
Brugia malayi | 6-phosphofructokinase | 0.013 | 0.603 | 0.603 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0019 | 0.0307 | 0.0307 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.2969 | 0.2969 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0208 | 1 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.013 | 0.603 | 0.603 |
Echinococcus multilocularis | lamin | 0.0032 | 0.1002 | 0.1002 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0087 | 0.3805 | 0.3805 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.013 | 0.603 | 0.5806 |
Echinococcus granulosus | lamin | 0.0032 | 0.1002 | 0.1002 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.182 | 0.182 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0019 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0044 | 0.1612 | 0.1612 |
Schistosoma mansoni | lamin | 0.0032 | 0.1002 | 0.1002 |
Echinococcus granulosus | dihydrofolate reductase | 0.0208 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0087 | 0.3805 | 0.3805 |
Schistosoma mansoni | jun-related protein | 0.0071 | 0.2969 | 0.2969 |
Schistosoma mansoni | 6-phosphofructokinase | 0.013 | 0.603 | 0.603 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0019 | 0.0307 | 0.0307 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0208 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0307 | 0.0307 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0019 | 0.0307 | 0.0307 |
Brugia malayi | Dihydrofolate reductase | 0.0208 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0044 | 0.1612 | 0.1612 |
Schistosoma mansoni | dihydrofolate reductase | 0.0208 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 1 | 1 |
Echinococcus granulosus | phd:f box containing protein | 0.0019 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0231 | 0.0231 |
Trypanosoma brucei | cytochrome P450, putative | 0.0023 | 0.0535 | 0.0397 |
Brugia malayi | phosphofructokinase | 0.013 | 0.603 | 0.603 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.007 | 0.2961 | 0.2961 |
Entamoeba histolytica | phosphofructokinase, putative | 0.013 | 0.603 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.013 | 0.603 | 0.603 |
Leishmania major | ATP-dependent phosphofructokinase | 0.013 | 0.603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0971 | 0.0971 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.007 | 0.2961 | 0.2961 |
Echinococcus multilocularis | musashi | 0.0032 | 0.1002 | 0.1002 |
Schistosoma mansoni | 6-phosphofructokinase | 0.013 | 0.603 | 0.603 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.33 uM | Activation of SMN2 promoter in mouse NSC34 cells assessed as induction of beta-lactamase activity | ChEMBL. | 18205293 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.