Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ferritin light chain | 0.0017 | 0.03 | 0.03 |
Schistosoma mansoni | ferritin | 0.0017 | 0.03 | 0.03 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0017 | 0.03 | 0.5 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0296 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.3785 | 0.3785 |
Schistosoma mansoni | ferritin | 0.0017 | 0.03 | 0.03 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0115 | 0.3728 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.2879 | 0.2879 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.2879 | 0.2879 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0017 | 0.03 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.3785 | 0.3785 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.2879 | 0.2879 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0017 | 0.03 | 0.5 |
Schistosoma mansoni | ferritin light chain | 0.0017 | 0.03 | 0.03 |
Schistosoma mansoni | apoferritin-2 | 0.0017 | 0.03 | 0.03 |
Echinococcus multilocularis | expressed protein | 0.0017 | 0.03 | 0.03 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.3785 | 0.3785 |
Schistosoma mansoni | apoferritin-2 | 0.0017 | 0.03 | 0.03 |
Echinococcus granulosus | ferritin | 0.0017 | 0.03 | 0.03 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0017 | 0.03 | 0.5 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0296 | 1 | 1 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0017 | 0.03 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0296 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.2879 | 0.2879 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.2879 | 0.2879 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.2879 | 0.2879 |
Schistosoma mansoni | ferritin | 0.0017 | 0.03 | 0.03 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.2879 | 0.2879 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.3728 | 0.5 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0017 | 0.03 | 0.5 |
Schistosoma mansoni | ferritin | 0.0017 | 0.03 | 0.03 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.2879 | 0.2879 |
Trichomonas vaginalis | ferritin, putative | 0.0017 | 0.03 | 0.5 |
Echinococcus multilocularis | ferritin | 0.0017 | 0.03 | 0.03 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0017 | 0.03 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.2879 | 0.2879 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0296 | 1 | 1 |
Echinococcus granulosus | expressed protein | 0.0017 | 0.03 | 0.03 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.3728 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.2 nM | Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels | ChEMBL. | 18023581 |
IC50 (binding) | = 1.2 nM | Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels | ChEMBL. | 18023581 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.