Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase domain 10 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | disintegrin and metalloproteinase | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Schistosoma japonicum | ko:K04712 fatty acid desaturase, putative | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Schistosoma mansoni | dihydroceramide desaturase | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Brugia malayi | Disintegrin family protein | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Loa Loa (eye worm) | disintegrin family protein | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Echinococcus multilocularis | disintegrin and metalloproteinase | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrix metalloproteinase | 0.0047 | 0.169 | 0.2743 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0281 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2377 | 0.3858 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0028 | 0.0386 | 0.0107 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0058 | 0.2377 | 0.5 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.0028 | 0.0386 | 0.0107 |
Onchocerca volvulus | 0.0047 | 0.169 | 0.2683 | |
Schistosoma mansoni | dihydroceramide desaturase | 0.0102 | 0.5326 | 1 |
Echinococcus granulosus | adam | 0.0048 | 0.1761 | 0.1522 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0068 | 0.3056 | 0.2855 |
Onchocerca volvulus | 0.0067 | 0.3007 | 0.5194 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0249 | 0.0405 |
Brugia malayi | Matrixin family protein | 0.0047 | 0.169 | 0.2743 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0102 | 0.5326 | 0.5191 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0048 | 0.1761 | 0.2933 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0281 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.169 | 0.2743 |
Brugia malayi | Matrixin family protein | 0.0047 | 0.169 | 0.2743 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0068 | 0.3056 | 0.2855 |
Brugia malayi | Matrixin family protein | 0.0115 | 0.616 | 1 |
Brugia malayi | Disintegrin family protein | 0.0102 | 0.5326 | 0.8646 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0105 | 0.553 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0105 | 0.553 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.3007 | 0.5403 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0028 | 0.0386 | 0.0207 |
Onchocerca volvulus | Matrilysin homolog | 0.0047 | 0.169 | 0.2683 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0102 | 0.5326 | 0.5191 |
Brugia malayi | Hemopexin family protein | 0.0067 | 0.3007 | 0.4882 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0281 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3056 | 0.496 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.005 | 0.1865 | 0.3139 |
Loa Loa (eye worm) | disintegrin family protein | 0.0074 | 0.3477 | 0.5645 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0281 | 0.0457 |
Brugia malayi | Matrixin family protein | 0.0047 | 0.169 | 0.2743 |
Mycobacterium ulcerans | hydrolase | 0.0058 | 0.2377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0281 | 0.0457 |
Brugia malayi | Matrixin family protein | 0.0047 | 0.169 | 0.2743 |
Loa Loa (eye worm) | reprolysin | 0.0028 | 0.0386 | 0.0626 |
Loa Loa (eye worm) | matrixin family protein | 0.0105 | 0.553 | 0.8977 |
Brugia malayi | hypothetical protein | 0.0048 | 0.1761 | 0.2858 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.169 | 0.2743 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0386 | 0.0626 |
Loa Loa (eye worm) | matrixin family protein | 0.0115 | 0.616 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0058 | 0.2377 | 0.3858 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0028 | 0.0386 | 0.0207 |
Echinococcus granulosus | adam 17 protease | 0.0028 | 0.0386 | 0.0107 |
Echinococcus multilocularis | adam | 0.0048 | 0.1761 | 0.1522 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0058 | 0.2377 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0172 | 1 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0047 | 0.169 | 0.2792 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.169 | 0.2743 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.5 nM | Inhibition of HER2 sheddase in human BT474 cells | ChEMBL. | 18068976 |
IC50 (binding) | = 6.5 nM | Inhibition of HER2 sheddase in human BT474 cells | ChEMBL. | 18068976 |
IC50 (binding) | = 9.1 nM | Inhibition of ADAM10 (unknown origin) | ChEMBL. | 18068976 |
IC50 (binding) | = 9.1 nM | Inhibition of ADAM10 (unknown origin) | ChEMBL. | 18068976 |
IC50 (binding) | = 1272 nM | Inhibition of MMP2 (unknown origin) | ChEMBL. | 18068976 |
IC50 (binding) | = 1272 nM | Inhibition of MMP2 (unknown origin) | ChEMBL. | 18068976 |
IC50 (binding) | > 5000 nM | Inhibition of MMP1 (unknown origin) | ChEMBL. | 18068976 |
IC50 (binding) | > 5000 nM | Inhibition of MMP1 (unknown origin) | ChEMBL. | 18068976 |
Stabilty (ADMET) | = 50 % | Metabolic stability in human liver microsomes | ChEMBL. | 18068976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.