Detailed information for compound 50787

Basic information

Technical information
  • TDR Targets ID: 50787
  • Name: 133627-20-0
  • MW: 274.706 | Formula: C13H11ClN4O
  • H donors: 1 H acceptors: 3 LogP: 2.04 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c2nccc(c2[nH]c(=O)c2c1nccc2)Cl
  • InChi: 1S/C13H11ClN4O/c1-2-18-11-8(4-3-6-15-11)13(19)17-10-9(14)5-7-16-12(10)18/h3-7H,2H2,1H3,(H,17,19)
  • InChiKey: AAWWSWAOXUPEEG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS003197
  • 4-Chloro-N11-ethyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
  • AIDS-003197
  • Dipyridodiazepinone deriv. 98
  • 4-Chloro-N11-ethyl-5,11-dihydro-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0075 0.1321
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0027 0.0047 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0172 0.3795
Echinococcus granulosus neuropeptide FF receptor 2 0.0032 0.0075 0.0138
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0075 0.1321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0075 0.1321
Loa Loa (eye worm) hypothetical protein 0.0082 0.0355 0.0355
Echinococcus multilocularis follistatin 0.0082 0.0355 0.6264
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0075 0.1321
Brugia malayi GnHR receptor homolog 0.0032 0.0075 0.0075
Onchocerca volvulus 0.012 0.0566 0.0522
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0032 0.0075 0.0075
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0032 0.0075 0.0075
Echinococcus multilocularis expressed protein 0.0082 0.0355 0.6264
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus multilocularis sex peptide receptor 0.0032 0.0075 0.1321
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0075 0.1321
Onchocerca volvulus 0.012 0.0566 0.0522
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.0075 0.1321
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus granulosus g-protein coupled receptor 0.0032 0.0075 0.0138
Giardia lamblia Ribonuclease H 0.0027 0.0047 0.2736
Brugia malayi hypothetical protein 0.012 0.0566 0.0566
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.0075 0.1321
Loa Loa (eye worm) hypothetical protein 0.012 0.0566 0.0566
Schistosoma mansoni amine GPCR 0.0032 0.0075 0.1321
Schistosoma mansoni phosphoglucomutase 0.0027 0.0047 0.0831
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus multilocularis allatostatin A receptor 0.0032 0.0075 0.1321
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0032 0.0075 0.0138
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0075 0.0138
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0075 0.0138
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0172 1
Brugia malayi sulfakinin receptor protein 0.0032 0.0075 0.0075
Echinococcus granulosus somatostatin receptor 0.0032 0.0075 0.0138
Loa Loa (eye worm) hypothetical protein 0.1824 1 1
Schistosoma mansoni follistatin 0.0082 0.0355 0.6264
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.0075 0.1321
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0075 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0172 0.3037
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0032 0.0075 0.1321
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0075 0.0138
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0172 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Onchocerca volvulus 0.0032 0.0075 0.0028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus granulosus g protein coupled receptor 0.0032 0.0075 0.0138
Echinococcus multilocularis agrin 0.0082 0.0355 0.6264
Echinococcus granulosus neuropeptide receptor 0.0032 0.0075 0.0138
Brugia malayi sodium-independent organic anion transporter family protein 0.012 0.0566 0.0566
Echinococcus granulosus Solute carrier organic anion transporter family 0.012 0.0566 0.1042
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0172 0.3037
Schistosoma mansoni amine GPCR 0.0032 0.0075 0.1321
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0075 0.0138
Schistosoma mansoni neuropeptide receptor 0.0032 0.0075 0.1321
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0082 0.0355 0.6264
Echinococcus granulosus orexin receptor type 2 0.0032 0.0075 0.0138
Schistosoma mansoni agrin 0.0082 0.0355 0.6264
Brugia malayi larval opioid receptor 0.0032 0.0075 0.0075
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0172 0.3037
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0075 0.0138
Echinococcus granulosus allatostatin A receptor 0.0032 0.0075 0.0138
Echinococcus granulosus Solute carrier family 22 5 0.1 0.5438 1
Schistosoma mansoni amine GPCR 0.0032 0.0075 0.1321
Schistosoma mansoni hypothetical protein 0.01 0.0453 0.8002
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.006 0.1315
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0075 0.0138
Brugia malayi RNase H family protein 0.0027 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus granulosus tachykinin peptides receptor 99D 0.0032 0.0075 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0075 0.1321
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0075 0.1321
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.0075 0.1321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0075 0.1321
Brugia malayi RNase H family protein 0.0027 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Trypanosoma brucei unspecified product 0.0029 0.006 0.1315
Schistosoma mansoni myosin xvIII 0.0032 0.0075 0.1321
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0082 0.0355 0.6264
Brugia malayi sodium-independent organic anion transporter family protein 0.012 0.0566 0.0566
Brugia malayi Dopamine receptor protein 2 0.0032 0.0075 0.0075
Brugia malayi Tachykinin-like peptides receptor 99D 0.0032 0.0075 0.0075
Schistosoma mansoni amine GPCR 0.0032 0.0075 0.1321
Loa Loa (eye worm) hypothetical protein 0.012 0.0566 0.0566
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0032 0.0075 0.0138
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0075 0.1321
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0075 0.1321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0075 0.1321
Leishmania major ribonuclease H1, putative 0.0027 0.0047 0.2736
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0075 0.1321
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0032 0.0075 0.0075
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.0075 0.1321
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0075 0.0138
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0075 0.0138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.0075 0.1321
Brugia malayi ORL1-like opioid receptor 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0075 0.0138
Trypanosoma cruzi MFS transporter, putative 0.012 0.0566 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.0075 0.1321
Brugia malayi AKH receptor 0.0032 0.0075 0.0075
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0032 0.0075 0.0075
Brugia malayi G-protein coupled receptor 0.0032 0.0075 0.0075
Schistosoma mansoni neuropeptide receptor 0.0032 0.0075 0.1321
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.0075 0.1321
Onchocerca volvulus 0.0032 0.0075 0.0028
Brugia malayi putative neuropeptide receptor NPR1 0.0032 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0032 0.0075 0.1321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0075 0.1321
Onchocerca volvulus Putative organic anion transporter 0.1824 1 1
Onchocerca volvulus 0.0032 0.0075 0.0028
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.0075 0.1321
Loa Loa (eye worm) hypothetical protein 0.0082 0.0355 0.0355
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.0075 0.1321
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0075 0.1321
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.0075 0.1321
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0172 0.3037
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0082 0.0355 0.6264
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0 0.5
Schistosoma mansoni opsin-like receptor 0.0032 0.0075 0.1321
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.0075 0.1321
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0075 0.0138
Echinococcus multilocularis somatostatin receptor 0.0032 0.0075 0.1321
Echinococcus granulosus fmrfamide receptor 0.0032 0.0075 0.0138
Brugia malayi Serotonin receptor 0.0032 0.0075 0.0075
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0075 0.1321
Echinococcus granulosus G protein coupled receptor 139 0.0032 0.0075 0.0138
Loa Loa (eye worm) hypothetical protein 0.0082 0.0355 0.0355
Echinococcus multilocularis orexin receptor type 2 0.0032 0.0075 0.1321
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0082 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Onchocerca volvulus 0.012 0.0566 0.0522
Echinococcus granulosus 7tm_1 domain containing protein 0.0032 0.0075 0.0138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0075 0.0075
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0075 0.1321
Loa Loa (eye worm) TYRA-2 protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.012 0.0566 0.0566
Schistosoma mansoni organic anion transporter 0.012 0.0566 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0172 0.0172
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0075 0.1321
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.0075 0.1321
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0082 0.0355 0.0355
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0172 0.0316
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0172 1
Brugia malayi putative neuropeptide receptor 0.0032 0.0075 0.0075
Onchocerca volvulus 0.0032 0.0075 0.0028
Echinococcus granulosus g protein coupled receptor 0.0032 0.0075 0.0138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Brugia malayi Serotonin receptor 0.0032 0.0075 0.0075
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.0075 0.1321
Brugia malayi hypothetical protein 0.0032 0.0075 0.0075
Schistosoma mansoni opsin-like receptor 0.0032 0.0075 0.1321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0075 0.1321
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.0075 0.1321
Brugia malayi hypothetical protein 0.0032 0.0075 0.0075
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.0075 0.1321
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0172 0.3037
Toxoplasma gondii transporter, major facilitator family protein 0.012 0.0566 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0032 0.0075 0.0075
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0075 0.1321
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0075 0.1321
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0075 0.1321
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0075 0.1321
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0075 0.0075
Schistosoma mansoni amine GPCR 0.0032 0.0075 0.1321
Brugia malayi hypothetical protein 0.0032 0.0075 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0075 0.1321
Onchocerca volvulus 0.0032 0.0075 0.0028
Echinococcus granulosus neuropeptide s receptor 0.0032 0.0075 0.0138
Brugia malayi Dopamine receptor protein 1 0.0032 0.0075 0.0075
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.0075 0.1321
Brugia malayi RE15519p 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus multilocularis serotonin receptor 0.0032 0.0075 0.1321
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0032 0.0075 0.0075
Brugia malayi RNase H family protein 0.0027 0.0047 0.0047
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.0075 0.1321
Echinococcus granulosus hypothetical protein 0.0032 0.0075 0.0138
Onchocerca volvulus 0.0032 0.0075 0.0028
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.0075 0.1321
Schistosoma mansoni biogenic amine receptor 0.0032 0.0075 0.1321
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0075 0.1321
Echinococcus granulosus neuropeptide receptor A26 0.0032 0.0075 0.0138
Schistosoma mansoni neuropeptide receptor 0.0032 0.0075 0.1321
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0075 0.1321
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus granulosus alpha 1A adrenergic receptor 0.0032 0.0075 0.0138
Schistosoma mansoni biogenic amine receptor 0.0032 0.0075 0.1321
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0075 0.0138
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0082 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus granulosus g protein coupled receptor 0.0032 0.0075 0.0138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0075 0.1321
Onchocerca volvulus 0.0032 0.0075 0.0028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Brugia malayi hypothetical protein 0.0032 0.0075 0.0075
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0082 0.0355 0.0355
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0032 0.0075 0.0138
Schistosoma mansoni hypothetical protein 0.0032 0.0075 0.1321
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0172 0.0316
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0172 1
Schistosoma mansoni phosphoglucomutase 0.0027 0.0047 0.0831
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Brugia malayi hypothetical protein 0.0032 0.0075 0.0075
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0047 0.0831
Echinococcus granulosus agrin 0.0082 0.0355 0.0652
Toxoplasma gondii protease inhibitor PI2 0.0082 0.0355 0.6264
Onchocerca volvulus Putative organic anion transporter 0.012 0.0566 0.0522
Brugia malayi hypothetical protein 0.0032 0.0075 0.0075
Echinococcus multilocularis Solute carrier organic anion transporter family 0.012 0.0566 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0075 0.0075
Schistosoma mansoni biogenic amine receptor 0.0032 0.0075 0.1321
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0075 0.0138
Brugia malayi MAP kinase sur-1 0.0049 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0082 0.0355 0.0355
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0075 0.1321
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0075 0.1321
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0032 0.0075 0.0028
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.0075 0.1321
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0075 0.1321
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0075 0.1321
Onchocerca volvulus 0.0032 0.0075 0.0028
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0075 0.0138
Onchocerca volvulus 0.012 0.0566 0.0522
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0075 0.1321
Echinococcus granulosus ribonuclease H1 0.0027 0.0047 0.0087
Schistosoma mansoni adenoreceptor 0.0032 0.0075 0.1321
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0075 0.1321
Loa Loa (eye worm) agrin synaptic family protein 0.0082 0.0355 0.0355
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0172 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0032 0.0075 0.0075
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.0075 0.1321
Echinococcus granulosus 7TM GPCR rhodopsin 0.0032 0.0075 0.0138
Brugia malayi hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.012 0.0566 0.0566
Echinococcus granulosus neuropeptide receptor 0.0032 0.0075 0.0138
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.0075 0.1321
Onchocerca volvulus 0.012 0.0566 0.0522
Onchocerca volvulus 0.0032 0.0075 0.0028
Echinococcus multilocularis serotonin receptor 0.0032 0.0075 0.1321
Schistosoma mansoni hypothetical protein 0.0032 0.0075 0.1321
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0075 0.1321
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.006 0.1315
Brugia malayi hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Brugia malayi Dopamine receptor 0.0032 0.0075 0.0075
Brugia malayi follicle stimulating hormone receptor 0.0254 0.1306 0.1306
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.006 0.1315
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0172 1
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0047 0.0831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0075 0.1321
Schistosoma mansoni phosphoglucomutase 0.0027 0.0047 0.0831
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Onchocerca volvulus 0.0032 0.0075 0.0028
Schistosoma mansoni opsin-like receptor 0.0032 0.0075 0.1321
Trypanosoma brucei ribonuclease H1 0.0027 0.0047 0.1038
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0075 0.0138
Echinococcus granulosus follistatin 0.0082 0.0355 0.0652
Trichomonas vaginalis ribonuclease H1, putative 0.0027 0.0047 0.2736
Echinococcus granulosus sex peptide receptor 0.0032 0.0075 0.0138
Treponema pallidum ribonuclease H (rnhA) 0.0027 0.0047 1
Brugia malayi SPARC precursor 0.0082 0.0355 0.0355
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0032 0.0075 0.0075
Onchocerca volvulus Putative organic anion transporter 0.012 0.0566 0.0522
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0075 0.0138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.0075 0.1321
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0075 0.0138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0032 0.0075 0.0075
Schistosoma mansoni organic anion transporter 0.012 0.0566 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0172 0.3037
Loa Loa (eye worm) hypothetical protein 0.012 0.0566 0.0566
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0075 0.1321
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0075 0.1321
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.0075 0.1321
Trypanosoma brucei RNA helicase, putative 0.01 0.0453 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0075 0.0138
Brugia malayi secreted modular calcium-binding protein 1 0.0082 0.0355 0.0355
Echinococcus granulosus dro:myosuppressin receptor 0.0032 0.0075 0.0138
Onchocerca volvulus 0.0032 0.0075 0.0028
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0075 0.1321
Echinococcus multilocularis ribonuclease H1 0.0027 0.0047 0.0831
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0029 0.006 0.1315
Echinococcus granulosus organic anion transporting polypeptide 30B 0.012 0.0566 0.1042
Onchocerca volvulus 0.0032 0.0075 0.0028
Toxoplasma gondii ribonuclease HI protein 0.0027 0.0047 0.0831
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0075 0.0138
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0075 0.1321
Loa Loa (eye worm) sodium-independent organic anion transporter 0.012 0.0566 0.0566
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.0075 0.1321
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.1306 0.1306
Brugia malayi neuropeptide F receptor 0.0032 0.0075 0.0075
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0172 0.3037
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0075 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0075 0.1321
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0075 0.1321
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.0075 0.1321
Onchocerca volvulus 0.0032 0.0075 0.0028
Brugia malayi G protein-coupled receptor 0.0032 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0075
Onchocerca volvulus Neuropeptide F receptor homolog 0.0032 0.0075 0.0028
Onchocerca volvulus 0.0032 0.0075 0.0028
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0075 0.1321
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0075 0.1321
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.012 0.0566 1
Brugia malayi Melatonin receptor type 1A 0.0032 0.0075 0.0075
Schistosoma mansoni histamine h1 receptor 0.0032 0.0075 0.1321
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0082 0.0355 0.6264
Onchocerca volvulus 0.0082 0.0355 0.0309
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0082 0.0355 0.0355
Brugia malayi hypothetical protein 0.0032 0.0075 0.0075
Onchocerca volvulus 0.0032 0.0075 0.0028
Brugia malayi hypothetical protein 0.012 0.0566 0.0566
Brugia malayi neuropeptide F receptor 0.0032 0.0075 0.0075
Brugia malayi hypothetical protein 0.0032 0.0075 0.0075
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0172 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0032 0.0075 0.0138
Echinococcus granulosus serotonin receptor 0.0032 0.0075 0.0138
Brugia malayi sodium-independent organic anion transporter family protein 0.012 0.0566 0.0566
Trypanosoma brucei protein kinase, putative 0.0049 0.0172 0.3795
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0075 0.1321
Onchocerca volvulus 0.0032 0.0075 0.0028
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0172 0.3037
Brugia malayi G-protein coupled receptor 0.0032 0.0075 0.0075
Schistosoma mansoni neuropeptide receptor 0.0032 0.0075 0.1321
Onchocerca volvulus 0.0032 0.0075 0.0028
Loa Loa (eye worm) hypothetical protein 0.012 0.0566 0.0566

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 0.095 uM Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) ChEMBL. 12086483
Activity (binding) = 0.095 uM Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) ChEMBL. 12086483
IC50 (binding) = 0.095 uM Inhibition of HIV-1 reverse transcriptase at 37 degree centigrade ChEMBL. 11170624
IC50 (binding) = 0.095 uM In vitro inhibitory activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) ChEMBL. 1712395
IC50 (binding) = 0.095 uM Inhibition of HIV-1 reverse transcriptase at 37 degree centigrade ChEMBL. 11170624
IC50 (binding) = 0.095 uM In vitro inhibitory activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) ChEMBL. 1712395
Inhibition (binding) = 100 % In vitro inhibitory activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) at a concentration of 10 ug/mL. ChEMBL. 1712395
Inhibition (binding) = 100 % In vitro inhibitory activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) at a concentration of 10 ug/mL. ChEMBL. 1712395

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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