Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0198 | 0.5896 | 0.5896 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0489 | 0.0489 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.0026 | 0.0026 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0017 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | TAR-binding protein | 0.0053 | 0.1271 | 0.1271 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0038 | 0.0801 | 0.0801 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0038 | 0.0801 | 0.0801 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0038 | 0.0801 | 0.0801 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0019 | 0.0191 | 0.1315 |
Echinococcus multilocularis | snurportin 1 | 0.0253 | 0.7644 | 0.7644 |
Echinococcus granulosus | cathepsin l1 | 0.0014 | 0.0026 | 0.0026 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0327 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0053 | 0.1271 | 0.1271 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0014 | 0.0026 | 0.0026 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0038 | 0.0801 | 0.0801 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0053 | 0.1271 | 0.1271 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1283 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0024 | 0.0334 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1283 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1283 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.004 | 0.0867 | 0.0867 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0489 | 0.0489 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0017 | 0.0135 | 0.0865 |
Schistosoma mansoni | tar DNA-binding protein | 0.0053 | 0.1271 | 0.1271 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0038 | 0.0801 | 0.0801 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0014 | 0.0026 | 0.0026 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1283 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0026 | 0.0026 |
Brugia malayi | TAR-binding protein | 0.0053 | 0.1271 | 0.1271 |
Loa Loa (eye worm) | ctsf protein | 0.0014 | 0.0026 | 0.0026 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0049 | 0.1135 | 0.8824 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.5896 | 0.5896 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0029 | 0.0489 | 0.0489 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1283 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0024 | 0.0334 | 0.0334 |
Loa Loa (eye worm) | RNA binding protein | 0.0053 | 0.1271 | 0.1271 |
Plasmodium falciparum | importin beta, putative | 0.0024 | 0.0334 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.004 | 0.0867 | 0.0867 |
Entamoeba histolytica | Ran family GTPase | 0.0017 | 0.0135 | 0.6578 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.0026 | 0.0026 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0014 | 0.0026 | 0.0026 |
Entamoeba histolytica | hypothetical protein | 0.0019 | 0.0191 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.0026 | 0.0026 |
Leishmania major | cathepsin L-like protease | 0.0054 | 0.1283 | 1 |
Brugia malayi | hypothetical protein | 0.0198 | 0.5896 | 0.5896 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0017 | 0.0135 | 0.0135 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.0026 | 0.0026 |
Leishmania major | GTP-binding protein, putative | 0.0017 | 0.0135 | 0.0865 |
Trichomonas vaginalis | importin beta-1, putative | 0.0019 | 0.0191 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0014 | 0.0026 | 0.0026 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0038 | 0.0801 | 0.0801 |
Echinococcus granulosus | tar DNA binding protein | 0.0053 | 0.1271 | 0.1271 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0014 | 0.0026 | 0.0026 |
Plasmodium vivax | importin-beta 2, putative | 0.0024 | 0.0334 | 1 |
Leishmania major | cathepsin L-like protease | 0.0054 | 0.1283 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0024 | 0.0334 | 0.0334 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.0026 | 0.0026 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0017 | 0.0135 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1283 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.4006 | 0.4006 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0017 | 0.0135 | 0.3528 |
Schistosoma mansoni | hypothetical protein | 0.0253 | 0.7644 | 0.7644 |
Brugia malayi | RNA, U transporter 1 | 0.0067 | 0.1727 | 0.1727 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0014 | 0.0026 | 0.0026 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0014 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0042 | 0.091 | 0.091 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0014 | 0.0026 | 0.0026 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1283 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.0026 | 0.0026 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0054 | 0.1283 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0038 | 0.0801 | 0.0801 |
Schistosoma mansoni | Hyaluronidase | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hyaluronidase | 0.0327 | 1 | 1 |
Onchocerca volvulus | 0.004 | 0.0867 | 1 | |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0253 | 0.7644 | 0.7644 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0024 | 0.0334 | 0.1737 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0014 | 0.0026 | 0.0026 |
Schistosoma mansoni | ran | 0.0017 | 0.0135 | 0.0135 |
Leishmania major | cathepsin L-like protease | 0.0054 | 0.1283 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0038 | 0.0801 | 0.0801 |
Brugia malayi | Importin beta-1 subunit | 0.0024 | 0.0334 | 0.0334 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0014 | 0.0026 | 0.0026 |
Schistosoma mansoni | importin beta-1 | 0.0024 | 0.0334 | 0.0334 |
Echinococcus multilocularis | tar DNA binding protein | 0.0053 | 0.1271 | 0.1271 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1283 | 1 |
Schistosoma mansoni | ran | 0.0017 | 0.0135 | 0.0135 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0053 | 0.1271 | 0.1271 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0017 | 0.0135 | 0.0135 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0327 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0053 | 0.1271 | 0.1271 |
Schistosoma mansoni | tar DNA-binding protein | 0.0053 | 0.1271 | 0.1271 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0017 | 0.0135 | 0.3528 |
Schistosoma mansoni | tar DNA-binding protein | 0.0053 | 0.1271 | 0.1271 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0038 | 0.0801 | 0.0801 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0014 | 0.0026 | 0.0026 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0198 | 0.5896 | 0.5896 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1283 | 1 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0017 | 0.0135 | 0.0865 |
Echinococcus multilocularis | cysteine protease | 0.0014 | 0.0026 | 0.0026 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0019 | 0.0191 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0054 | 0.1283 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0053 | 0.1271 | 0.1271 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0054 | 0.1283 | 1 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0017 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0334 | 0.0334 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0042 | 0.091 | 0.091 |
Leishmania major | importin beta-1 subunit, putative | 0.0019 | 0.0191 | 0.1315 |
Loa Loa (eye worm) | fibroinase | 0.0014 | 0.0026 | 0.0026 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0019 | 0.0191 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1283 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0042 | 0.091 | 0.091 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0024 | 0.0334 | 0.1737 |
Loa Loa (eye worm) | cysteine protease | 0.0014 | 0.0026 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0867 | 0.0867 |
Echinococcus granulosus | snurportin 1 | 0.0253 | 0.7644 | 0.7644 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0054 | 0.1283 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0014 | 0.0026 | 0.0026 |
Trichomonas vaginalis | ran, putative | 0.0017 | 0.0135 | 0.6578 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.091 | 0.091 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0054 | 0.1283 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0042 | 0.0918 | 0.7098 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0017 | 0.0135 | 0.3528 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kinact (binding) | = 0.036 uM | Inhibition of human family 20 beta-hexosaminidase | ChEMBL. | 17439950 |
Kinact (binding) | = 0.046 uM | Inhibition of human family 84 O-GLcNAcase | ChEMBL. | 17439950 |
Kinact (binding) | = 0.046 uM | Inhibition of human family 84 O-GLcNAcase | ChEMBL. | 17439950 |
Kinact (binding) | = 0.048 uM | Inhibition of Vibrio cholerae NagZ | ChEMBL. | 17439950 |
Kinact (binding) | = 0.048 uM | Inhibition of Vibrio cholerae NagZ | ChEMBL. | 17439950 |
Selectivity ratio (binding) | = 1 | Ratio of human 84 O-GLcNAcase to Vibrio cholerae NagZ | ChEMBL. | 17439950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.