Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | diacylglycerol lipase, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0369 | 0.0883 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0088 | 0.0852 | 0.1384 |
Mycobacterium leprae | Probable lipase LipE | 0.0069 | 0.0369 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0069 | 0.0369 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0069 | 0.0369 | 0.0883 |
Toxoplasma gondii | ABC1 family protein | 0.0069 | 0.0369 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0173 | 0.3053 | 0.7309 |
Brugia malayi | beta-lactamase family protein | 0.0069 | 0.0369 | 0.0883 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.3053 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0069 | 0.0369 | 0.0599 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.3053 | 0.8743 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0088 | 0.0852 | 0.244 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0069 | 0.0369 | 0.0599 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0088 | 0.0852 | 0.244 |
Brugia malayi | beta-lactamase | 0.0069 | 0.0369 | 0.0883 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0088 | 0.0852 | 0.1384 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0088 | 0.0852 | 0.204 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.019 | 0.3492 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0069 | 0.0369 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0069 | 0.0369 | 0.1056 |
Brugia malayi | beta-lactamase family protein | 0.0069 | 0.0369 | 0.0883 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.3053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0369 | 0.0883 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0069 | 0.0369 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0088 | 0.0852 | 0.204 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.3053 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0173 | 0.3053 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0069 | 0.0369 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0369 | 0.0883 |
Loa Loa (eye worm) | beta-lactamase | 0.0069 | 0.0369 | 0.0883 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.3053 | 0.8743 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0369 | 0.0883 |
Plasmodium vivax | hypothetical protein, conserved | 0.0069 | 0.0369 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0369 | 0.0883 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.6157 | 1 |
Onchocerca volvulus | 0.0173 | 0.3053 | 1 | |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0069 | 0.0369 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0088 | 0.0852 | 0.1384 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.3053 | 1 |
Brugia malayi | Lipase family protein | 0.0173 | 0.3053 | 0.7309 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0088 | 0.0852 | 0.244 |
Brugia malayi | follicle stimulating hormone receptor | 0.0216 | 0.4177 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0369 | 0.0883 |
Mycobacterium leprae | conserved hypothetical protein | 0.0069 | 0.0369 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0088 | 0.0852 | 0.244 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0216 | 0.4177 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.3053 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0069 | 0.0369 | 0.0883 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.019 | 0.3492 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.3053 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0069 | 0.0369 | 0.1056 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 26.3 uM | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | = 26.3 uM | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | > 100 uM | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | > 100 uM | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
Efficacy (functional) | = 5.4 % | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 10 uM relative to ionomycin | ChEMBL. | 18424134 |
Efficacy (functional) | = 5.4 % | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 10 uM relative to ionomycin | ChEMBL. | 18424134 |
Efficacy (functional) | = 83.2 % | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 100 uM relative to mustard oil | ChEMBL. | 18424134 |
Efficacy (functional) | = 83.2 % | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 100 uM relative to mustard oil | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human MAGL mediated [14C]2-AG hydrolysis in COS cell | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG in COS cell | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG in COS cell | ChEMBL. | 18424134 |
IC50 (functional) | = 24.8 uM | Inhibition of [14C]anandamide uptake in rat RBL-2H3 | ChEMBL. | 18424134 |
IC50 (binding) | > 50 uM | Inhibition of rat brain FAAH mediated [14C]anandamide hydrolysis | ChEMBL. | 18424134 |
IC50 (binding) | > 50 uM | Inhibition of rat brain FAAH mediated [14C]anandamide hydrolysis | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB1 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB2 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB1 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB2 receptor expressed in COS cells | ChEMBL. | 18424134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.