Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | interleukin-1 receptor-associated kinase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | acetyltransferase, GNAT family protein | 0.0166 | 0.3185 | 0.2784 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0067 | 0.0615 | 0.0615 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0157 | 0.2965 | 0.2367 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0157 | 0.2965 | 0.2367 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0067 | 0.0615 | 0.0615 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0161 | 0.3064 | 0.3064 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0049 | 0.0132 | 0.0132 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0049 | 0.0132 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0076 | 0.083 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.4477 | 0.4182 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0049 | 0.0132 | 0.5 |
Leishmania major | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0157 | 0.2965 | 0.2367 |
Trypanosoma brucei | Emopamil binding protein, putative | 0.0157 | 0.2965 | 0.2367 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0076 | 0.083 | 0.0233 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0157 | 0.2965 | 0.2367 |
Leishmania major | hypothetical protein, conserved | 0.0157 | 0.2965 | 0.2367 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0166 | 0.3185 | 0.3185 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0067 | 0.0615 | 0.0615 |
Onchocerca volvulus | 0.0157 | 0.2965 | 0.5 | |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0421 | 0.985 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0421 | 0.985 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0166 | 0.3185 | 0.2784 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0421 | 0.985 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0049 | 0.0132 | 0.5 |
Echinococcus multilocularis | expressed protein | 0.0427 | 1 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0045 | 0.0026 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0076 | 0.083 | 0.0836 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0076 | 0.083 | 0.083 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0067 | 0.0615 | 0.0615 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0421 | 0.985 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0076 | 0.083 | 0.0233 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0049 | 0.0132 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0049 | 0.0132 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.985 | 1 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0157 | 0.2965 | 0.2367 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0045 | 0.0026 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0076 | 0.083 | 0.083 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0166 | 0.3185 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.