Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2Y, G-protein coupled, 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | purinergic receptor P2Y, G-protein coupled, 1 | 373 aa | 393 aa | 17.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0402 | 0.985 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0158 | 0.3185 | 0.2784 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0402 | 0.985 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0402 | 0.985 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0158 | 0.3185 | 0.3185 |
Leishmania major | hypothetical protein, conserved | 0.015 | 0.2965 | 0.2367 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.015 | 0.2965 | 0.2367 |
Onchocerca volvulus | 0.015 | 0.2965 | 0.5 | |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0064 | 0.0615 | 0.0615 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 0.985 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0047 | 0.0132 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.083 | 0.083 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0158 | 0.3185 | 1 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.015 | 0.2965 | 0.2367 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0043 | 0.0026 | 0.5 |
Echinococcus multilocularis | expressed protein | 0.0408 | 1 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0043 | 0.0026 | 0.5 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0047 | 0.0132 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0047 | 0.0132 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.083 | 0.0233 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0402 | 0.985 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.083 | 0.083 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0064 | 0.0615 | 0.0615 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.083 | 0.0836 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.015 | 0.2965 | 0.2367 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0064 | 0.0615 | 0.0615 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0158 | 0.3185 | 0.2784 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0064 | 0.0615 | 0.0615 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.015 | 0.2965 | 0.2367 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0047 | 0.0132 | 0.5 |
Leishmania major | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.015 | 0.2965 | 0.2367 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.4477 | 0.4182 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0072 | 0.083 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0072 | 0.083 | 0.0233 |
Trypanosoma brucei | Emopamil binding protein, putative | 0.015 | 0.2965 | 0.2367 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0047 | 0.0132 | 0.0132 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0154 | 0.3064 | 0.3064 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0047 | 0.0132 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.