Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | activin A receptor, type IB | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | TGF-beta receptor type-1 | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Echinococcus granulosus | TGF beta receptor type 1 | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Echinococcus multilocularis | TGF beta receptor type 1 | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Schistosoma japonicum | ko:K04674 transforming growth factor, beta receptor I, putative | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Brugia malayi | bone morphogenetic protein type 1 receptor | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Schistosoma mansoni | protein kinase | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 0.0055 | 0.007 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0191 | 0.4475 | 0.5642 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0192 | 0.4495 | 0.3986 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0208 | 0.5043 | 0.4585 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0074 | 0.0406 | 0.0512 |
Brugia malayi | Neuronal symmetry protein 1 | 0.0208 | 0.5043 | 0.6173 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0074 | 0.0406 | 0.0512 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0063 | 0.002 | 0.5 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0192 | 0.4495 | 0.3986 |
Schistosoma mansoni | protein kinase | 0.0086 | 0.0826 | 0.0205 |
Brugia malayi | glutaminase DH11.1 | 0.0291 | 0.7931 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0063 | 0.002 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0208 | 0.5043 | 0.4585 |
Schistosoma mansoni | glutaminase | 0.0291 | 0.7931 | 0.7791 |
Schistosoma mansoni | hypothetical protein | 0.035 | 1 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0291 | 0.7931 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0291 | 0.7931 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0192 | 0.4495 | 0.4123 |
Brugia malayi | Protein kinase domain containing protein | 0.0074 | 0.0406 | 0.0027 |
Schistosoma mansoni | protein kinase | 0.0208 | 0.5043 | 0.4708 |
Trichomonas vaginalis | glutaminase, putative | 0.0291 | 0.7931 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5023 | 0.6333 |
Schistosoma mansoni | protein kinase | 0.0208 | 0.5043 | 0.4708 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0102 | 0.1359 | 0.056 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0192 | 0.4495 | 0.3986 |
Loa Loa (eye worm) | glutaminase | 0.0291 | 0.7931 | 1 |
Schistosoma mansoni | hypothetical protein | 0.035 | 1 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0102 | 0.1359 | 0.056 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0386 | 0.0487 |
Brugia malayi | jmjC domain containing protein | 0.0102 | 0.1359 | 0.129 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0191 | 0.4475 | 0.5419 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0063 | 0.002 | 0.0026 |
Echinococcus multilocularis | geminin | 0.035 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.928 uM | Inhibition of TGFbeta type receptor 1 ALK5 (T204D) (unknown origin) expressed in Sf9 cells | ChEMBL. | 18314943 |
IC50 (binding) | = 0.928 uM | Inhibition of TGFbeta type receptor 1 ALK5 (T204D) (unknown origin) expressed in Sf9 cells | ChEMBL. | 18314943 |
IC50 (functional) | = 0.951 uM | Antiproliferative activity against mink Mv1Lu-p3TP-Lux cells by luciferase reporter assay | ChEMBL. | 18314943 |
IC50 (functional) | = 1.03 uM | Antiproliferative activity against mouse NIH3T3 cells by [3H]thymidine assay | ChEMBL. | 18314943 |
IC50 (functional) | = 1.03 uM | Antiproliferative activity against mouse NIH3T3 cells by [3H]thymidine assay | ChEMBL. | 18314943 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 18314943 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.