Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0106 | 0.1308 | 0.3839 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0116 | 0.161 | 0.4727 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0106 | 0.1308 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0116 | 0.161 | 0.4727 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0102 | 0.118 | 0.1241 |
Schistosoma mansoni | alpha glucosidase | 0.0106 | 0.1308 | 0.1149 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0068 | 0.0178 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0116 | 0.161 | 0.4727 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0401 | 1 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.028 | 0.6443 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0106 | 0.1308 | 0.3839 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0434 | 0.0434 |
Brugia malayi | flavodoxin family protein | 0.0076 | 0.0434 | 0.0434 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0106 | 0.1308 | 0.7018 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0106 | 0.1308 | 0.3839 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0122 | 0.1788 | 0.1788 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0074 | 0.0374 | 0.1098 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0106 | 0.1308 | 0.3839 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0169 | 0.3177 | 0.3177 |
Onchocerca volvulus | Putative endochitinase | 0.0122 | 0.1788 | 0.2825 |
Mycobacterium tuberculosis | Possible chitinase | 0.0102 | 0.118 | 0.5 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.028 | 0.6443 | 0.6281 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0068 | 0.0178 | 0.0524 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0106 | 0.1308 | 0.3839 |
Onchocerca volvulus | Putative endochitinase | 0.0134 | 0.2138 | 0.3378 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0106 | 0.1308 | 0.0913 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0076 | 0.0434 | 0.0434 |
Trypanosoma brucei | glucosidase, putative | 0.0106 | 0.1308 | 1 |
Brugia malayi | Endochitinase | 0.0134 | 0.2138 | 0.2138 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.118 | 0.118 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0076 | 0.0434 | 0.159 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0076 | 0.0434 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0116 | 0.161 | 0.4727 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0106 | 0.1308 | 0.3839 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.028 | 0.6443 | 0.6281 |
Schistosoma mansoni | alpha-glucosidase | 0.0334 | 0.8039 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0106 | 0.1308 | 0.3839 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0169 | 0.3177 | 0.3177 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0116 | 0.161 | 0.4727 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0102 | 0.118 | 0.1241 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0116 | 0.161 | 0.2545 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0076 | 0.0434 | 0.1275 |
Onchocerca volvulus | Putative endochitinase | 0.0134 | 0.2138 | 0.3378 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0106 | 0.1308 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0177 | 0.3406 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0134 | 0.2138 | 0.3378 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0106 | 0.1308 | 1 |
Leishmania major | p450 reductase, putative | 0.0076 | 0.0434 | 0.159 |
Schistosoma mansoni | alpha-glucosidase | 0.0334 | 0.8039 | 1 |
Onchocerca volvulus | 0.0276 | 0.6327 | 1 | |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0076 | 0.0434 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0076 | 0.0434 | 0.0434 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0106 | 0.1308 | 0.0913 |
Onchocerca volvulus | Putative endochitinase | 0.0122 | 0.1788 | 0.2825 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0177 | 0.3406 | 1 |
Brugia malayi | endochitinase | 0.0134 | 0.2138 | 0.2138 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0177 | 0.3406 | 0.3406 |
Entamoeba histolytica | chitinase, putative | 0.0122 | 0.1788 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0116 | 0.161 | 0.4727 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0123 | 0.1795 | 0.5269 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0106 | 0.1308 | 0.3839 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0169 | 0.3177 | 0.3607 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0401 | 1 | 1 |
Leishmania major | chitinase | 0.0122 | 0.1788 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0106 | 0.1308 | 0.1308 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0177 | 0.3406 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0401 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0177 | 0.3406 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0106 | 0.1308 | 0.1308 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0074 | 0.0374 | 0.1098 |
Brugia malayi | endochitinase | 0.0122 | 0.1788 | 0.1788 |
Loa Loa (eye worm) | chitinase I | 0.0122 | 0.1788 | 0.1788 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0177 | 0.3406 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0177 | 0.3406 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0401 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0123 | 0.1795 | 0.5269 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0177 | 0.3406 | 0.3406 |
Giardia lamblia | Hypothetical protein | 0.0068 | 0.0178 | 0.5 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0114 | 0.153 | 0.153 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0116 | 0.161 | 0.4727 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0106 | 0.1308 | 0.3839 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pTD50 (functional) | = 1.076 | Anticarcinogenic activity in rat assessed as induction of tumors per day | ChEMBL. | 18295489 |
TD50 (functional) | = 11.907 umol/Kg | Anticarcinogenic activity in rat assessed as induction of tumors per day | ChEMBL. | 18295489 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.