Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dual specificity | 0.0062 | 0.7243 | 0.7302 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.7243 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.7243 | 1 |
Echinococcus granulosus | dual specificity | 0.0062 | 0.7243 | 0.7302 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.7243 | 1 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0014 | 0 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0014 | 0 | 0.5 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0062 | 0.7243 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0079 | 0.9918 | 0.9918 |
Echinococcus multilocularis | dual specificity | 0.0062 | 0.7243 | 0.7302 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0062 | 0.7243 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.7243 | 1 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0062 | 0.7243 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.7243 | 1 |
Echinococcus multilocularis | dual specificity | 0.0062 | 0.7243 | 0.7302 |
Brugia malayi | GSG2 | 0.0079 | 0.9918 | 1 |
Echinococcus granulosus | dual specificity | 0.0062 | 0.7243 | 0.7302 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.7243 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0079 | 0.9918 | 0.9918 |
Brugia malayi | hypothetical protein | 0.0079 | 0.9918 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0062 | 0.7243 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0062 | 0.7243 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.7243 | 0.7302 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0062 | 0.7243 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0079 | 0.9918 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0062 | 0.7243 | 0.5 |
Plasmodium falciparum | MO15-related protein kinase | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.9918 | 1 |
Echinococcus multilocularis | dual specificity | 0.0062 | 0.7243 | 0.7302 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0062 | 0.7243 | 0.7243 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0062 | 0.7243 | 0.7302 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Inhibition of human autotaxin expressed in MDA-MB-435 cells assessed as fluorescent lysophosphatidyl choline analog hydrolysis at 10 uM | ChEMBL. | 18036821 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.