Detailed information for compound 515668

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 420.488 | Formula: C21H20N6O2S
  • H donors: 4 H acceptors: 3 LogP: 3.46 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=S)NN/C=C/C(=O)c1c(nn(c1C)c1ccccc1)C(=O)Nc1ccccc1
  • InChi: 1S/C21H20N6O2S/c1-14-18(17(28)12-13-23-25-21(22)30)19(20(29)24-15-8-4-2-5-9-15)26-27(14)16-10-6-3-7-11-16/h2-13,23H,1H3,(H,24,29)(H3,22,25,30)/b13-12+
  • InChiKey: ASWASOMGLHWTPF-OUKQBFOZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0021 0.0227 0.0898
Loa Loa (eye worm) hypothetical protein 0.0013 0.0108 0.0429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0043 0.0172
Schistosoma mansoni ap endonuclease 0.0015 0.0144 0.017
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.005 0.0669 0.0787
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0043 0.0051
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0144 0.4263
Toxoplasma gondii aldehyde dehydrogenase 0.005 0.0669 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0144 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0172
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0227 0.671
Loa Loa (eye worm) jmjC domain-containing protein 0.0048 0.0645 0.2553
Toxoplasma gondii exonuclease III APE 0.0015 0.0144 0.2156
Brugia malayi jmjC domain containing protein 0.0013 0.0108 0.0429
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0009 0.0054 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0043 0.0172
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0043 0.0051
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0208 0.3115
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0043 0.0051
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0043 0.0172
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0028 0.0338 0.5058
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0109 0.1575 0.6236
Brugia malayi jmjC domain containing protein 0.0013 0.0108 0.0429
Echinococcus granulosus lysine specific demethylase 5A 0.0048 0.0645 0.0759
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0028 0.0338 0.0398
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0108 0.0429
Echinococcus granulosus microtubule associated protein 2 0.0565 0.8497 1
Leishmania major hypothetical protein, conserved 0.0013 0.0108 0.1623
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0172
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0028 0.0338 1
Echinococcus multilocularis phd:f box containing protein 0.0013 0.0108 0.0108
Echinococcus multilocularis jumonji domain containing 1A 0.0013 0.0108 0.0108
Echinococcus multilocularis beta catenin 0.0109 0.1575 0.1575
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0122 0.182
Brugia malayi nuclear receptor NHR-88 0.0009 0.0043 0.0172
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0043 0.0043
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0108 0.0429
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0019 0.0208 0.3115
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0043 0.0051
Onchocerca volvulus 0.0172 0.2526 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0028 0.0338 0.5058
Schistosoma mansoni coup transcription factor 0.0009 0.0043 0.0051
Loa Loa (eye worm) hypothetical protein 0.0172 0.2526 1
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0043 0.0051
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0014 0.0134 0.2
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0028 0.0338 0.0398
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0108 0.0108
Schistosoma mansoni jumonji domain containing protein 0.0048 0.0645 0.0759
Schistosoma mansoni ap endonuclease 0.0015 0.0144 0.017
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0043 0.0051
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0014 0.0134 0.2
Plasmodium falciparum JmjC domain-containing protein, putative 0.0013 0.0108 0.3208
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0227 0.671
Schistosoma mansoni phd/f-box containing protein 0.0013 0.0108 0.0128
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0043 0.0051
Echinococcus granulosus jumonji domain containing 1A 0.0013 0.0108 0.0128
Brugia malayi hypothetical protein 0.0013 0.0116 0.0458
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0048 0.0645 0.0645
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0043 0.0172
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0144 0.2156
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0028 0.0338 1
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0043 0.0172
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0028 0.0338 1
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0208 0.0825
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.005 0.0669 0.0669
Onchocerca volvulus Cirhin homolog 0.0109 0.1564 0.6192
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0028 0.0338 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0144 0.4263
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0108 0.0128
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0208 0.3115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0043 0.0172
Brugia malayi nuclear hormone receptor 0.0009 0.0043 0.0172
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0529
Loa Loa (eye worm) hypothetical protein 0.0019 0.0208 0.0825
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0043 0.0172
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0172
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0043 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0043 0.0172
Brugia malayi eukaryotic initiation factor 4A 0.0028 0.0338 0.1339
Schistosoma mansoni protein phosphatase 2C 0.0013 0.0108 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0043 0.0172
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0172
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0208 0.3115
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0108 0.0429
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0028 0.0338 0.0338
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.005 0.0669 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0144 0.2156
Schistosoma mansoni jumonji domain containing protein 0.0013 0.0108 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0043 0.0172
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0043 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0043 0.0172
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0043 0.0043
Onchocerca volvulus 0.0019 0.0208 0.0825
Onchocerca volvulus 0.0009 0.0043 0.0172
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0014 0.0134 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0043 0.0051
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0043 0.0172
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0013 0.0108 0.1623
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.0669 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0048 0.0645 0.0645
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0028 0.0338 1
Brugia malayi jmjC domain containing protein 0.0013 0.0108 0.0429
Loa Loa (eye worm) hypothetical protein 0.0019 0.0208 0.0825
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0019 0.0208 0.3115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0208 0.0825
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0645 0.0759
Echinococcus granulosus phd:f box containing protein 0.0013 0.0108 0.0128
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0144 0.017
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0227 0.671
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0172
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0043 0.0172
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0043 0.0172
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0013 0.0108 0.3208
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0043 0.0172
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0013 0.0108 0.3208
Schistosoma mansoni aldehyde dehydrogenase 0.005 0.0669 0.0787
Leishmania major hypothetical protein, conserved 0.0021 0.0227 0.3394
Loa Loa (eye worm) hypothetical protein 0.0028 0.0338 0.1339
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0028 0.0338 0.1339
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0043 0.0172
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0043 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.005 0.0669 0.0787
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0144 0.4263
Plasmodium vivax acyl-CoA synthetase, putative 0.0014 0.0134 0.3955
Echinococcus granulosus lysine specific demethylase 6a 0.0013 0.0108 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0043 0.0172
Treponema pallidum ATP-dependent RNA helicase 0.0028 0.0338 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0144 0.4263
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0043 0.0051
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0043 0.0051
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0013 0.0108 0.0128
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.0669 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0144 0.4263
Echinococcus multilocularis JmjC domain containing protein 4 0.0013 0.0108 0.0108
Plasmodium falciparum acyl-CoA synthetase 0.0014 0.0134 0.3955
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0122 0.182
Echinococcus multilocularis lysine specific demethylase 6a 0.0013 0.0108 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0043 0.0172
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0043 0.0043
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0043 0.0051
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0144 0.0571
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0227 0.3394
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0019 0.0208 0.3115
Brugia malayi steroid hormone receptor 0.0009 0.0043 0.0172
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0043 0.0043
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0019 0.0208 0.3115
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0208 0.0825
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0208 0.3115
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0122 0.182
Echinococcus granulosus beta catenin 0.0109 0.1575 0.1854
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0028 0.0338 1
Plasmodium vivax RNA helicase-1, putative 0.0028 0.0338 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.0669 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0108 0.0429
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0208 0.3115
Schistosoma mansoni microtubule-associated protein tau 0.0565 0.8497 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0028 0.0338 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0529
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0043 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0043 0.0172
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0144 0.0144
Entamoeba histolytica acyl-coA synthetase, putative 0.0019 0.0208 0.6159
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0208 0.6159
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0028 0.0338 0.0338
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0043 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0043 0.0172
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0208 0.3115
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0529
Leishmania major eukaryotic initiation factor 4a, putative 0.0028 0.0338 0.5058
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0208 0.3115
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0208 0.6159
Onchocerca volvulus 0.0171 0.2508 0.9928
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0172
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.005 0.0669 1
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0043 0.0043
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0043 0.0051
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0013 0.0108 0.1623
Mycobacterium ulcerans hypothetical protein 0.0019 0.0208 0.3115
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0043 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0043 0.0172
Plasmodium falciparum eukaryotic initiation factor 4A 0.0028 0.0338 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0122 0.182
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0529
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0009 0.0054 0.0054
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0144 0.2156
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0208 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0013 0.0108 0.3208
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0208 0.3115
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0028 0.0338 0.0398
Plasmodium vivax JmjC domain containing protein 0.0013 0.0108 0.3208
Echinococcus granulosus eukaryotic initiation factor 4A 0.0028 0.0338 0.0398
Schistosoma mansoni beta-catenin 0.0109 0.1575 0.1854
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0645 0.0759
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0144 0.4263
Brugia malayi hypothetical protein 0.0021 0.0227 0.0898
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0227 0.671
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0043 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0043 0.0051
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0144 0.0571
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0144 0.4263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0043 0.0172
Echinococcus granulosus JmjC domain containing protein 4 0.0013 0.0108 0.0128
Loa Loa (eye worm) hypothetical protein 0.0013 0.0108 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0043 0.0172
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0043 0.0043
Schistosoma mansoni phosphatidylserine receptor 0.0013 0.0108 0.0128
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0227 0.671
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0048 0.0645 0.0759
Brugia malayi jmjC domain containing protein 0.0048 0.0645 0.2553
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0043 0.0172
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0043 0.0172
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0144 0.4263
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0043 0.0051
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0208 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0043 0.0051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0043 0.0043
Brugia malayi ecdysteroid receptor 0.0009 0.0043 0.0172
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0529
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0172
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0172
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0172 0.2526 1
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0208 0.0825
Schistosoma mansoni hypothetical protein 0.0009 0.0054 0.0064
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0043 0.0051
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0028 0.0338 0.5058
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0028 0.0338 1
Loa Loa (eye worm) HMP-2 protein 0.0109 0.1575 0.6236
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0227 0.671
Brugia malayi jmjC domain containing protein 0.0013 0.0108 0.0429
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0043 0.0051
Echinococcus multilocularis microtubule associated protein 2 0.0565 0.8497 0.8497
Brugia malayi jmjC domain containing protein 0.0048 0.0645 0.2553

Activities

Activity type Activity value Assay description Source Reference
IZ (functional) = 0 mm/mg Antifungal activity against Aspergillus fumigatus after 24 hrs by agar diffusion test ChEMBL. 18313934
IZ (functional) = 8 mm/mg Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by agar diffusion test ChEMBL. 18313934
IZ (functional) = 10 mm/mg Antibacterial activity against Staphylococcus aureus after 24 hrs by agar diffusion test ChEMBL. 18313934
IZ (functional) = 12 mm/mg Antifungal activity against Candida albicans after 24 hrs by agar diffusion test ChEMBL. 18313934
IZ (functional) = 12 mm/mg Antifungal activity against Candida albicans after 24 hrs by agar diffusion test ChEMBL. 18313934

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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