Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | laminin gamma-3 chain | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.3891 | 0.3891 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | slit 2 protein | 0.0031 | 1 | 1 |
Echinococcus granulosus | pikachurin | 0.0025 | 0.3891 | 0.3891 |
Echinococcus multilocularis | pikachurin | 0.0025 | 0.3891 | 0.3891 |
Echinococcus multilocularis | slit 2 protein | 0.0031 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 1 | 1 |
Brugia malayi | laminin-like protein K08C7.3 precursor | 0.0025 | 0.3891 | 0.3891 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Brugia malayi | Thrombospondin N-terminal -like domain containing protein | 0.0025 | 0.3891 | 0.3891 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.3891 | 0.3891 |
Schistosoma mansoni | chondroitin sulfate proteoglycan-related | 0.0025 | 0.3891 | 0.3891 |
Loa Loa (eye worm) | abnormal epIthelia family member | 0.0025 | 0.3891 | 0.3891 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0025 | 0.3891 | 0.3891 |
Brugia malayi | laminin alpha chain | 0.0025 | 0.3891 | 0.3891 |
Schistosoma mansoni | cell polarity protein | 0.0025 | 0.3891 | 0.3891 |
Schistosoma mansoni | slit | 0.0031 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0025 | 0.3891 | 0.3891 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.043 nM | Inhibition of human factor 10a | ChEMBL. | 18329876 |
Ki (binding) | = 0.043 nM | Inhibition of human factor 10a | ChEMBL. | 18329876 |
Papp (ADMET) | = 3.5 10^-6 cm/s | Apparent permeability across human Caco2 cells | ChEMBL. | 18329876 |
Papp (ADMET) | = 3.5 10^-6 cm/s | Apparent permeability across human Caco2 cells | ChEMBL. | 18329876 |
PT (functional) | = 4.4 uM | Anticoagulant efficacy in human citrated plasma assessed as concentration required to double prothrombin time | ChEMBL. | 18329876 |
Selectivity ratio (binding) | > 1000 | Selectivity for human factor 10a over thrombin (unknown origin) | ChEMBL. | 18329876 |
Selectivity ratio (binding) | > 1000 | Selectivity for human factor 10a over trypsin (unknown origin) | ChEMBL. | 18329876 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.