Detailed information for compound 536578

Basic information

Technical information
  • TDR Targets ID: 536578
  • Name: N-(4-formylphenyl)acetamide
  • MW: 163.173 | Formula: C9H9NO2
  • H donors: 1 H acceptors: 2 LogP: 0.56 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1ccc(cc1)NC(=O)C
  • InChi: 1S/C9H9NO2/c1-7(12)10-9-4-2-8(6-11)3-5-9/h2-6H,1H3,(H,10,12)
  • InChiKey: SKLUWKYNZNXSLX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-methanoylphenyl)ethanamide
  • 4-acetaminobenzaldehyde
  • 51870-20-3
  • 122-85-0
  • NSC1774
  • 4'-Formylacetanilide
  • 4-Acetamidobenzaldehyde
  • 4-Acetylaminobenzaldehyde
  • 4-Formylacetanilide
  • Acetamide, N-(4-formylphenyl)-
  • Acetanilide, 4'-formyl-
  • Benzaldehyde, 4-acetamido-
  • Micotiazone
  • NSC1701
  • p-(Acetylamino)benzaldehyde
  • p-Acetamidobenzaldehyde
  • p-Acetaminobenzaldehyde
  • p-Acetylaminobenzaldehyde
  • p-Formylacetanilide
  • para-Acetaminobenzaldehyde
  • ZINC00164653
  • InChI=1/C9H9NO2/c1-7(12)10-9-4-2-8(6-11)3-5-9/h2-6H,1H3,(H,10,12
  • A1800_ALDRICH
  • AI3-18873
  • Acetanilide, 4'-formyl- (8CI)
  • EINECS 204-579-2
  • NSC 1701

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.2091 0.2132
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0021 0.1307 0.0795
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.1766 0.128
Brugia malayi nuclear receptor RXR 0.0021 0.1307 0.1333
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.9811 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.9811 0.98
Brugia malayi Nuclear hormone receptor E75 0.0021 0.1307 0.1333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0046 0.5585 0.5693
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.5585 0.5325
Schistosoma mansoni ap endonuclease 0.0022 0.1363 0.0854
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.1363 0.5
Echinococcus granulosus intermediate filament protein 0.0026 0.2177 0.1716
Echinococcus multilocularis FTZ F1 alpha 0.0046 0.5585 0.5325
Schistosoma mansoni retinoic acid receptor RXR 0.0046 0.5585 0.5325
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.7186 0.7324
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.2177 0.2219
Schistosoma mansoni steroid hormone receptor ad4bp 0.0046 0.5585 0.5325
Schistosoma mansoni hypothetical protein 0.0037 0.4117 0.3771
Echinococcus granulosus lamin 0.0026 0.2177 0.1716
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.5585 0.5693
Echinococcus granulosus thyroid hormone receptor alpha 0.0021 0.1307 0.0795
Loa Loa (eye worm) hypothetical protein 0.0021 0.1307 0.1333
Brugia malayi nuclear receptor NHR-88 0.0021 0.1307 0.1333
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0046 0.5585 0.5325
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.7186 0.7324
Echinococcus multilocularis nuclear receptor nhr 48 0.0021 0.1307 0.0795
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.1363 0.0854
Loa Loa (eye worm) nuclear hormone receptor 0.0021 0.1307 0.1333
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.1363 0.5
Echinococcus multilocularis lamin dm0 0.0026 0.2177 0.1716
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.1307 0.0795
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.1307 0.0795
Onchocerca volvulus 0.0046 0.5585 1
Echinococcus granulosus tar DNA binding protein 0.0069 0.9811 0.98
Echinococcus multilocularis thyroid hormone receptor alpha 0.0046 0.5585 0.5325
Loa Loa (eye worm) TAR-binding protein 0.0069 0.9811 1
Brugia malayi tailless protein 0.0021 0.1307 0.1333
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.5585 0.5325
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.1307 0.0795
Loa Loa (eye worm) hypothetical protein 0.0021 0.1307 0.1333
Loa Loa (eye worm) hypothetical protein 0.0021 0.1307 0.1333
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.1363 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.1766 0.18
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0556 0.0567
Schistosoma mansoni thyroid hormone receptor 0.0046 0.5585 0.5325
Schistosoma mansoni tar DNA-binding protein 0.0069 0.9811 0.98
Echinococcus granulosus lamin dm0 0.0026 0.2177 0.1716
Brugia malayi hypothetical protein 0.0021 0.1307 0.1333
Brugia malayi steroid hormone receptor 0.0046 0.5585 0.5693
Loa Loa (eye worm) hypothetical protein 0.0046 0.5585 0.5693
Brugia malayi intermediate filament protein 0.0026 0.2177 0.2219
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.1363 0.139
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0046 0.5585 0.5325
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0046 0.5585 0.5693
Loa Loa (eye worm) hypothetical protein 0.0037 0.4117 0.4197
Loa Loa (eye worm) hypothetical protein 0.0021 0.1307 0.1333
Schistosoma mansoni nuclear receptor nhr-48 0.0021 0.1307 0.0795
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0021 0.1307 0.0795
Loa Loa (eye worm) hypothetical protein 0.0021 0.1307 0.1333
Brugia malayi nuclear hormone receptor 0.0021 0.1307 0.1333
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0046 0.5585 0.5325
Schistosoma mansoni aldehyde dehydrogenase 0.007 1 1
Brugia malayi nuclear receptor NHR-88 0.0046 0.5585 0.5693
Loa Loa (eye worm) hypothetical protein 0.0046 0.5585 0.5693
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.1363 0.0854
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0046 0.5585 0.5693
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0046 0.5585 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 1 1
Brugia malayi Nuclear hormone receptor E75 0.0021 0.1307 0.1333
Loa Loa (eye worm) DR-78 0.0021 0.1307 0.1333
Schistosoma mansoni tar DNA-binding protein 0.0069 0.9811 0.98
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.5585 0.5693
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.5585 0.5693
Schistosoma mansoni ap endonuclease 0.0022 0.1363 0.0854
Brugia malayi ecdysone receptor 0.0021 0.1307 0.1333
Loa Loa (eye worm) hypothetical protein 0.0055 0.7186 0.7324
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.1766 0.18
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.1307 0.1333
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0046 0.5585 0.5325
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0046 0.5585 0.5325
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0046 0.5585 0.5325
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.1363 0.5
Schistosoma mansoni intermediate filament proteins 0.0026 0.2177 0.1716
Brugia malayi hypothetical protein 0.0024 0.1766 0.18
Loa Loa (eye worm) hypothetical protein 0.0024 0.1766 0.18
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0046 0.5585 0.5693
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0046 0.5585 0.5693
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.1307 0.1333
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0021 0.1307 0.0795
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.1363 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.1766 0.128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0046 0.5585 0.5693
Schistosoma mansoni tar DNA-binding protein 0.0069 0.9811 0.98
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.7186 0.7324
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.1363 0.139
Echinococcus multilocularis musashi 0.0026 0.2177 0.1716
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.1363 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0046 0.5585 0.5693
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0046 0.5585 0.5693
Loa Loa (eye worm) hypothetical protein 0.0021 0.1307 0.1333
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.5585 0.5325
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.007 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.1363 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.5585 0.5325
Brugia malayi nuclear receptor NHR-67 0.0021 0.1307 0.1333
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0046 0.5585 0.5325
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.5585 0.5693
Brugia malayi ecdysteroid receptor 0.0046 0.5585 0.5693
Echinococcus granulosus nuclear receptor nhr 48 0.0021 0.1307 0.0795
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0046 0.5585 0.5325
Schistosoma mansoni nuclear receptor 0.0021 0.1307 0.0795
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0046 0.5585 0.5325
Schistosoma mansoni RAR-like nuclear receptor 0.0046 0.5585 0.5325
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0556 0.0567
Brugia malayi nuclear hormone receptor 0.0046 0.5585 0.5693
Loa Loa (eye worm) hypothetical protein 0.0024 0.1766 0.18
Onchocerca volvulus Bile acid receptor homolog 0.0046 0.5585 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0046 0.5585 0.5325
Loa Loa (eye worm) hypothetical protein 0.0021 0.1307 0.1333
Brugia malayi TAR-binding protein 0.0069 0.9811 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0046 0.5585 0.5693
Loa Loa (eye worm) hypothetical protein 0.0024 0.1766 0.18
Loa Loa (eye worm) hypothetical protein 0.0017 0.0556 0.0567
Brugia malayi conserved hypotetical protein 0.0021 0.1307 0.1333
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.5585 0.5693
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.1363 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.5585 0.5693
Brugia malayi Steroid receptor seven-up type 2 0.0046 0.5585 0.5693
Echinococcus multilocularis ecdysone induced protein 78C 0.0046 0.5585 0.5325
Echinococcus granulosus ecdysone induced protein 78C 0.0046 0.5585 0.5325
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.5585 0.5325
Schistosoma mansoni nuclear receptor 0.0021 0.1307 0.0795
Loa Loa (eye worm) hypothetical protein 0.0046 0.5585 0.5693
Schistosoma mansoni zinc finger protein 0.0021 0.1307 0.0795
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0046 0.5585 0.5693
Schistosoma mansoni nuclear hormone receptor 0.0021 0.1307 0.0795
Loa Loa (eye worm) RNA binding protein 0.0069 0.9811 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0046 0.5585 0.5325
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.5585 0.5693
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0046 0.5585 0.5693
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0046 0.5585 0.5325
Onchocerca volvulus 0.0026 0.2177 0.2033
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.1766 0.128
Brugia malayi nuclear receptor RXR 0.0024 0.1766 0.18
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.1307 0.0795
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0046 0.5585 0.5693
Schistosoma mansoni nuclear hormone receptor 0.0046 0.5585 0.5325
Loa Loa (eye worm) nuclear receptor NHR-67 0.0021 0.1307 0.1333
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0021 0.1307 0.0795
Loa Loa (eye worm) steroid hormone receptor 0.0046 0.5585 0.5693
Toxoplasma gondii aldehyde dehydrogenase 0.007 1 1
Brugia malayi hypothetical protein 0.0024 0.1766 0.18
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0046 0.5585 0.5325
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0021 0.1307 0.1333
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0046 0.5585 0.5693
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.1363 0.5
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0021 0.1307 0.0795
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.1363 0.5
Brugia malayi hypothetical protein 0.0021 0.1307 0.1333
Loa Loa (eye worm) hypothetical protein 0.0026 0.2177 0.2219
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.9811 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.1307 0.1333
Schistosoma mansoni thyroid hormone receptor 0.0046 0.5585 0.5325
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.5585 0.5693
Loa Loa (eye worm) hypothetical protein 0.0046 0.5585 0.5693
Loa Loa (eye worm) hypothetical protein 0.0021 0.1307 0.1333
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0046 0.5585 0.5693
Echinococcus granulosus FTZ F1 alpha 0.0046 0.5585 0.5325
Schistosoma mansoni nuclear hormone receptor 0.0021 0.1307 0.0795
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.1363 0.5
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.1307 0.1333
Loa Loa (eye worm) hypothetical protein 0.0046 0.5585 0.5693
Loa Loa (eye worm) hypothetical protein 0.0024 0.1766 0.18
Loa Loa (eye worm) hypothetical protein 0.0021 0.1307 0.1333
Loa Loa (eye worm) hypothetical protein 0.0046 0.5585 0.5693
Loa Loa (eye worm) intermediate filament protein 0.0026 0.2177 0.2219
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.1766 0.18
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.1307 0.0795
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0046 0.5585 0.5693
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.1307 0.1333
Onchocerca volvulus Protein ultraspiracle homolog 0.0046 0.5585 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.1307 0.1333
Echinococcus multilocularis lamin 0.0026 0.2177 0.1716
Loa Loa (eye worm) hypothetical protein 0.0024 0.1766 0.18
Schistosoma mansoni coup transcription factor 0.0046 0.5585 0.5325
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.1307 0.1333
Loa Loa (eye worm) hypothetical protein 0.0046 0.5585 0.5693
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.2177 0.2219
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0556 0.0567
Loa Loa (eye worm) hypothetical protein 0.0021 0.1307 0.1333
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0046 0.5585 0.5325
Echinococcus multilocularis tar DNA binding protein 0.0069 0.9811 0.98
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.1307 0.0795
Brugia malayi RNA binding protein 0.0069 0.9811 1
Schistosoma mansoni lamin 0.0026 0.2177 0.1716
Onchocerca volvulus 0.0026 0.2177 0.2033
Schistosoma mansoni lamin 0.0026 0.2177 0.1716
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.4117 0.4197
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.1766 0.128
Schistosoma mansoni tar DNA-binding protein 0.0069 0.9811 0.98

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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