Detailed information for compound 542851

Basic information

Technical information
  • TDR Targets ID: 542851
  • Name: N-(4-guanidinosulfonylphenyl)acridine-4-carbo xamide
  • MW: 419.456 | Formula: C21H17N5O3S
  • H donors: 3 H acceptors: 4 LogP: 2.63 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)NS(=O)(=O)c1ccc(cc1)NC(=O)c1cccc2c1nc1ccccc1c2
  • InChi: 1S/C21H17N5O3S/c22-21(23)26-30(28,29)16-10-8-15(9-11-16)24-20(27)17-6-3-5-14-12-13-4-1-2-7-18(13)25-19(14)17/h1-12H,(H,24,27)(H4,22,23,26)
  • InChiKey: VWLNAVUASYRUIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-guanidinosulfonylphenyl)-4-acridinecarboxamide
  • N-[4-[bis(azanyl)methylideneamino]sulfonylphenyl]acridine-4-carboxamide
  • N-[4-(diaminomethylideneamino)sulfonylphenyl]acridine-4-carboxamide
  • AIDS-138067
  • AIDS138067
  • N-(4-(((Amino(imino)methyl)amino)sulfonyl)phenyl)-4-acridinecarboxamide
  • NSC644044
  • NCI60_014937

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0057 0.0068
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0569 0.1224
Trypanosoma brucei glucose transporter, putative 0.0036 0.0354 0.0712
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0202 0.0347
Brugia malayi major facilitator superfamily protein 0.0016 0.0057 0.0173
Loa Loa (eye worm) hypothetical protein 0.0051 0.0579 0.1178
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0069 0.0208
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0822 0.0799
Echinococcus multilocularis pyruvate kinase 0.0035 0.0343 0.0319
Schistosoma mansoni sugar transporter 0.0016 0.0057 0.0032
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0069 0.0028
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0555 0.2392
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0424 0.0878
Onchocerca volvulus Putative transporter 0.0016 0.0057 0.1003
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0069 0.0016
Onchocerca volvulus 0.0016 0.0057 0.1003
Brugia malayi Doublecortin family protein 0.0019 0.0102 0.0311
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0295 0.027
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0579 0.1249
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0343 0.0685
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0149 0.0124
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0424 0.0878
Echinococcus granulosus solute carrier family 22 0.0016 0.0057 0.0032
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0155 0.013
Schistosoma mansoni hypothetical protein 0.0032 0.0295 0.027
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0133 0.1834 0.1813
Giardia lamblia Pyruvate kinase 0.0035 0.0343 1
Schistosoma mansoni hypothetical protein 0.0032 0.0295 0.027
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0116 0.1565 0.1543
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0164
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0149 0.0264
Trypanosoma brucei glucose transporter, putative 0.0036 0.0354 0.0712
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0579 0.0725
Onchocerca volvulus 0.0016 0.0057 0.1003
Echinococcus multilocularis solute carrier family 22 0.0016 0.0057 0.0032
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0271 0.0512
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0347 0.0323
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0343 1
Plasmodium falciparum glutathione reductase 0.0017 0.0069 0.0016
Onchocerca volvulus 0.0016 0.0057 0.1003
Echinococcus multilocularis solute carrier family 22 0.0016 0.0057 0.0032
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0343 0.0676
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0354 0.1973
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0035 0.0348 0.0404
Trypanosoma brucei glucose transporter, putative 0.0036 0.0354 0.0712
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0035 0.0347 0.0323
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0579 0.1249
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0184 0.0841
Leishmania major importin beta-1 subunit, putative 0.0025 0.0184 0.0303
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0069 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0337 0.0663
Trypanosoma brucei glucose transporter, putative 0.0036 0.0354 0.0712
Echinococcus granulosus tar DNA binding protein 0.0067 0.0822 0.0799
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0014 0.0025 0.0076
Brugia malayi RNA, U transporter 1 0.0086 0.112 0.3399
Brugia malayi follicle stimulating hormone receptor 0.023 0.3295 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0202 0.0695
Schistosoma mansoni pyruvate kinase 0.0035 0.0343 0.0319
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0069 0.0076
Onchocerca volvulus 0.0016 0.0057 0.1003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0164
Echinococcus granulosus GPCR family 2 0.0032 0.0295 0.027
Brugia malayi Thioredoxin reductase 0.0049 0.0555 0.1686
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0133 0.1834 0.4254
Plasmodium falciparum calcium-dependent protein kinase 1 0.0035 0.0348 0.0404
Entamoeba histolytica protein kinase, putative 0.0035 0.0347 0.1177
Schistosoma mansoni glucose transport protein 0.0116 0.1565 0.1543
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0343 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.151 0.6972
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0555 0.0692
Loa Loa (eye worm) hypothetical protein 0.003 0.0271 0.0523
Brugia malayi hypothetical protein 0.0019 0.0102 0.0311
Plasmodium falciparum glutathione reductase 0.0049 0.0555 0.0692
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0202 0.0347
Schistosoma mansoni ran 0.0022 0.0149 0.0124
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0069 0.0044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Plasmodium falciparum thioredoxin reductase 0.0049 0.0555 0.0692
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0271 0.0512
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0133 0.1834 0.3848
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0035 0.0347 0.1055
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0014 0.0025 0.0076
Onchocerca volvulus 0.0016 0.0057 0.1003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0202 0.0376
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0343 1
Entamoeba histolytica hypothetical protein 0.0025 0.0184 0.0205
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0202 0.0201
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0035 0.0347 0.0695
Leishmania major pyruvate kinase 0.0035 0.0343 0.0685
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0116 0.1565 0.1543
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Loa Loa (eye worm) sugar transporter 0.0116 0.1565 0.3275
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0295 0.0894
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0295 0.0573
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0295 0.027
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0432 0.0899
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0347 0.1927
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0025 0.0076
Loa Loa (eye worm) hypothetical protein 0.0028 0.0238 0.0453
Brugia malayi hypothetical protein 0.0019 0.0102 0.0311
Leishmania major glucose transporter, lmgt1 0.0036 0.0354 0.0712
Trypanosoma cruzi hexose transporter 0.0036 0.0354 0.0712
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0014 0.0025 0.0076
Echinococcus multilocularis GPCR, family 2 0.0032 0.0295 0.027
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0354 0.0712
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.004 0.0424 0.0779
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0035 0.0337 0.1022
Echinococcus granulosus transcription factor Dp 1 0.0077 0.0982 0.0959
Plasmodium falciparum calcium-dependent protein kinase 3 0.0035 0.0348 0.0404
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Giardia lamblia Prolyl-tRNA synthetase 0.0035 0.0337 0.9775
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0116 0.1565 0.1543
Schistosoma mansoni hypothetical protein 0.0023 0.0155 0.013
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0555 0.0532
Brugia malayi Sugar transporter family protein 0.0116 0.1565 0.4749
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0133 0.1834 0.4254
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0069 0.0055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.3246 0.3229
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0149 0.0128
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0354 0.0712
Toxoplasma gondii facilitative glucose transporter GT1 0.0116 0.1565 0.3201
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0555 0.1193
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0143 0.0412
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.3246 0.3229
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0149 0.0221
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0184 0.0303
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0202 0.0308
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0227 0.3246 0.9853
Plasmodium vivax importin-beta 2, putative 0.003 0.0271 0.0297
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0069 0.0028
Schistosoma mansoni hypothetical protein 0.0019 0.0102 0.0078
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0343 0.1041
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0069 0.0055
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0057 0.0032
Leishmania major protein kinase, putative 0.0035 0.0347 0.0695
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0579 0.1108
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0555 0.1128
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0202 0.4858
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0057 0.0032
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0343 0.1373
Brugia malayi hypothetical protein 0.0033 0.0306 0.093
Schistosoma mansoni hypothetical protein 0.0032 0.0295 0.027
Toxoplasma gondii protein kinase, putative 0.0327 0.4766 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.1699 0.7882
Echinococcus granulosus pyruvate kinase 0.0018 0.0084 0.0059
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0579 0.1249
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0084 0.0037
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0628 0.0605
Leishmania major hypothetical protein, conserved 0.0051 0.0579 0.1249
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0069 0.0028
Brugia malayi RNA binding protein 0.0067 0.0822 0.2495
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0057 0.0032
Trichomonas vaginalis ran, putative 0.0022 0.0149 0.0612
Brugia malayi hypothetical protein 0.0016 0.0057 0.0173
Brugia malayi glutathione reductase 0.0049 0.0555 0.1686
Echinococcus multilocularis General substrate transporter 0.0099 0.1318 0.1296
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0628 0.0605
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.1565 1
Mycobacterium ulcerans hypothetical protein 0.0154 0.2141 1
Brugia malayi hypothetical protein 0.0016 0.0057 0.0173
Trypanosoma brucei glucose transporter 2A 0.0036 0.0354 0.0712
Echinococcus multilocularis pyruvate kinase 0.0018 0.0084 0.0059
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0035 0.0348 0.0617
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0337 0.0312
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0202 0.0177
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1904 0.4422
Plasmodium vivax calcium-dependent protein kinase, putative 0.0035 0.0348 0.0404
Echinococcus granulosus RUN 0.0019 0.0102 0.0078
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0822 0.1695
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0069 0.0028
Echinococcus granulosus solute carrier family 22 0.0016 0.0057 0.0032
Brugia malayi TAR-binding protein 0.0067 0.0822 0.2495
Schistosoma mansoni rab6-interacting 0.0019 0.0102 0.0078
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.151 0.6972
Trypanosoma cruzi hexose transporter, putative 0.002 0.0108 0.0121
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0227 0.3246 0.6853
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0069 0.0016
Onchocerca volvulus 0.0016 0.0057 0.1003
Plasmodium vivax hexose transporter 0.0116 0.1565 0.2094
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0084 0.0057
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0014 0.0025 0.0076
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0579 0.0725
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4234 1
Treponema pallidum NADH oxidase 0.0017 0.0069 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0295 0.027
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0424 0.0878
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0069 0.0028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1904 0.4422
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0035 0.0347 0.0686
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0202 0.0961
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0149 0.3224
Echinococcus granulosus importin subunit beta 1 0.003 0.0271 0.0246
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Schistosoma mansoni pyruvate kinase 0.0035 0.0343 0.0319
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0133 0.1834 0.1813
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0149 0.0196
Schistosoma mansoni glucose transport protein 0.0116 0.1565 0.1543
Schistosoma mansoni hypothetical protein 0.0324 0.4726 0.4713
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.3246 0.3229
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0026 0.0003
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0149 0.0128
Plasmodium falciparum calcium-dependent protein kinase 4 0.0035 0.0348 0.0404
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0295 0.0894
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0133 0.1834 0.5567
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0102 0.0078
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0295 0.027
Echinococcus multilocularis pyruvate kinase 0.0018 0.0084 0.0059
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.4726 1
Echinococcus multilocularis geminin 0.0672 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.1699 0.7882
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0057 0.0032
Onchocerca volvulus 0.0016 0.0057 0.1003
Schistosoma mansoni glucose transport protein 0.0116 0.1565 0.1543
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0102 0.0078
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.1699 1
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0057 0.0173
Loa Loa (eye worm) hypothetical protein 0.0035 0.0337 0.0663
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0343 0.0676
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0102 0.0164
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0102 0.0063
Onchocerca volvulus 0.0016 0.0057 0.1003
Mycobacterium tuberculosis Probable reductase 0.0112 0.151 0.6972
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.151 0.6972
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.4234 1
Trypanosoma brucei glucose transporter, putative 0.0036 0.0354 0.0712
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0343 0.1897
Loa Loa (eye worm) hypothetical protein 0.0035 0.0343 0.0676
Plasmodium vivax glutathione reductase, putative 0.0049 0.0555 0.0692
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0202 0.0347
Loa Loa (eye worm) hypothetical protein 0.0101 0.1341 0.2799
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0354 0.1973
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0348 0.0404
Schistosoma mansoni sugar transporter 0.0016 0.0057 0.0032
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0069 0.0403
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0432 0.0899
Echinococcus granulosus pyruvate kinase 0.0035 0.0343 0.0319
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.151 0.6972
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0347 0.0323
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4234 1
Echinococcus granulosus solute carrier family 22 0.0016 0.0057 0.0032
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0354 0.0712
Brugia malayi basement membrane proteoglycan precursor 0.0014 0.0025 0.0076
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0069 0.0024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0295 0.0573
Schistosoma mansoni sugar transporter 0.0016 0.0057 0.0032
Trypanosoma brucei glucose transporter 1E 0.0036 0.0354 0.0712
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0116 0.1565 0.1543
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0069 0.0028
Schistosoma mansoni lipoxygenase 0.0054 0.0628 0.0605
Onchocerca volvulus 0.0016 0.0057 0.1003
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0579 0.0725
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0822 0.0799
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0822 0.0799
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0035 0.0337 0.0312
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0182 0.0194
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0057 0.0032
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0343 0.0607
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0822 0.0799
Onchocerca volvulus 0.0016 0.0057 0.1003
Brugia malayi Sugar transporter family protein 0.0016 0.0057 0.0173
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0187 0.2645 0.5495
Onchocerca volvulus 0.0016 0.0057 0.1003
Plasmodium falciparum proline--tRNA ligase 0.004 0.0424 0.051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0354 0.0712
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0035 0.0337 0.1855
Schistosoma mansoni hypothetical protein 0.0069 0.0856 0.0833
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0035 0.0347 0.0686
Echinococcus multilocularis pyruvate kinase 0.0028 0.0231 0.0206
Plasmodium falciparum mitogen-activated protein kinase 2 0.0187 0.2645 0.3595
Brugia malayi Cam kinase protein 1 0.0035 0.0347 0.1055
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0202 0.0201
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0069 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0343 0.0685
Loa Loa (eye worm) RNA binding protein 0.0067 0.0822 0.1695
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0149 0.0221
Trypanosoma brucei trypanothione reductase 0.0049 0.0555 0.1193
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0035 0.0337 0.0312
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0035 0.0337 0.1245
Schistosoma mansoni polycystin 1-related 0.0019 0.0102 0.0078
Brugia malayi hypothetical protein 0.0016 0.0057 0.0173
Plasmodium falciparum thioredoxin reductase 0.0017 0.0069 0.0016
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0424 0.0878
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0057 0.0068
Echinococcus granulosus pyruvate kinase 0.0018 0.0084 0.0059
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0069 0.0028
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.1699 0.7882
Plasmodium falciparum calcium-dependent protein kinase 2 0.0035 0.0348 0.0404
Loa Loa (eye worm) hypothetical protein 0.0025 0.0182 0.0333
Plasmodium falciparum hexose transporter 0.0116 0.1565 0.2094
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0069 0.0028
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0035 0.0337 0.1112
Leishmania major glucose transporter, lmgt2 0.0036 0.0354 0.0712
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0116 0.1565 0.1543
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0347 0.0323
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0202 0.0177
Brugia malayi Sugar transporter family protein 0.0016 0.0057 0.0173
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0555 0.0532
Echinococcus granulosus solute carrier family 22 0.0016 0.0057 0.0032
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.151 0.6972
Onchocerca volvulus 0.0016 0.0057 0.1003
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0343 0.1041
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0025 0.0076
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0337 0.0312
Plasmodium falciparum calcium-dependent protein kinase 5 0.0035 0.0348 0.0404
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0069 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0184 0.0841
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0822 0.1695
Toxoplasma gondii thioredoxin reductase 0.0049 0.0555 0.1058
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0014 0.0025 0.0076
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0343 0.0685
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0069 0.0044
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0116 0.1565 0.1543
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.3246 0.3229
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0202 0.0177
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0347 0.0323
Onchocerca volvulus 0.0016 0.0057 0.1003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0347 0.0686
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.4234 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0187 0.2645 0.3595
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0347 0.0323
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0069 0.0016
Chlamydia trachomatis pyruvate kinase 0.0035 0.0343 1
Schistosoma mansoni protein kinase 0.0035 0.0347 0.0323
Schistosoma mansoni hypothetical protein 0.0672 1 1
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0014 0.0025 0.0076
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0069 0.0076
Brugia malayi hypothetical protein 0.0051 0.0579 0.1757
Toxoplasma gondii hypothetical protein 0.0047 0.0524 0.0991
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0069 0.0028
Onchocerca volvulus 0.0019 0.0102 0.2432
Echinococcus granulosus snurportin 1 0.0324 0.4726 0.4713
Echinococcus granulosus pyruvate kinase 0.0018 0.0084 0.0059
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0035 0.0348 0.0617
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Brugia malayi Importin beta-1 subunit 0.003 0.0271 0.0822
Echinococcus multilocularis calcium dependent protein kinase 0.0033 0.0314 0.029
Echinococcus multilocularis importin subunit beta 1 0.003 0.0271 0.0246
Plasmodium falciparum pyruvate kinase 0.0035 0.0343 0.0397
Echinococcus multilocularis solute carrier family 22 0.0016 0.0057 0.0032
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0084 0.0037
Plasmodium falciparum protein kinase 7 0.0327 0.4766 0.6542
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0343 0.1897
Brugia malayi enteropeptidase precursor 0.0014 0.0025 0.0076
Loa Loa (eye worm) sugar transporter 0.0016 0.0057 0.0068
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0354 0.1973
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0343 0.0676
Echinococcus multilocularis solute carrier family 22 0.0016 0.0057 0.0032
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0343 0.0397
Echinococcus multilocularis pyruvate kinase 0.0018 0.0084 0.0059
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0069 0.0028
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0102 0.0078
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0149 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0354 0.1973
Trypanosoma brucei glucose transporter, putative 0.0036 0.0354 0.0712
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0343 0.0685
Brugia malayi major facilitator superfamily protein 0.0016 0.0057 0.0173
Schistosoma mansoni protein kinase 0.0035 0.0347 0.0323
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0143 0.0412
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.3295 0.6956
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0149 0.0453
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0347 0.0323
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0354 0.0712
Schistosoma mansoni ran 0.0022 0.0149 0.0124
Echinococcus granulosus General substrate transporter 0.0099 0.1318 0.1296
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0155 0.013
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0822 0.2495
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0202 0.5065
Echinococcus multilocularis transcription factor Dp 1 0.0077 0.0982 0.0959
Schistosoma mansoni rab6-interacting 0.0019 0.0102 0.0078
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0069 0.0028
Schistosoma mansoni sugar transporter 0.0016 0.0057 0.0032
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0035 0.0337 0.1022
Schistosoma mansoni hypothetical protein 0.0116 0.1565 0.1543
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0856 0.2599
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0116 0.1565 0.1543
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0133 0.1834 0.4254
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0347 0.0323
Schistosoma mansoni loxhd1 0.0019 0.0102 0.0078
Plasmodium falciparum protein kinase 6 0.0491 0.7255 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0069 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1341 0.4069
Entamoeba histolytica protein kinase, putative 0.0035 0.0347 0.1177
Plasmodium vivax proline--tRNA ligase, putative 0.004 0.0424 0.051
Schistosoma mansoni hypothetical protein 0.0032 0.0295 0.027
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0035 0.0348 0.0404
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0014 0.0025 0.0076
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0057 0.0173
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1341 0.2799
Entamoeba histolytica hypothetical protein 0.0026 0.0202 0.0313
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0057 0.0173
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0102 0.0078
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0202 0.0695
Schistosoma mansoni lipoxygenase 0.0019 0.0102 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0354 0.1973
Schistosoma mansoni pyruvate kinase 0.0018 0.0084 0.0059
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0202 0.0177
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.3246 0.3229
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0202 0.0613
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0424 0.0878
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0133 0.1834 0.1813
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0133 0.1834 0.4254
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0116 0.1565 0.1543
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0102 0.0078
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0069 0.0055
Onchocerca volvulus 0.0016 0.0057 0.1003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0432 0.0899
Leishmania major trypanothione reductase 0.0049 0.0555 0.1193
Plasmodium falciparum importin beta, putative 0.003 0.0271 0.0297
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1904 0.4422
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0202 0.0379
Giardia lamblia Pyruvate kinase 0.0018 0.0084 0.0936
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0822 0.0799
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0069 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0354 0.1973
Leishmania major pyruvate kinase 0.0035 0.0343 0.0685
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0069 0.0028
Leishmania major glucose transporter, lmgt3 0.0036 0.0354 0.0712
Onchocerca volvulus 0.0016 0.0057 0.1003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0184 0.0841
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0069 0.0028
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0035 0.0348 0.0617
Schistosoma mansoni glucose transporter 0.0016 0.0057 0.0032
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0069 0.0055
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0354 0.1973
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0069 0.0028
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0069 0.0028
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0343 0.1373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.3246 0.3229
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0154 0.0641
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0347 0.0323
Loa Loa (eye worm) glutathione reductase 0.0049 0.0555 0.1128
Onchocerca volvulus 0.0016 0.0057 0.1003
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0069 0.0044
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0432 0.0899
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0354 0.0712
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0343 0.1286
Echinococcus multilocularis snurportin 1 0.0324 0.4726 0.4713
Trypanosoma brucei glucose transporter, putative 0.0036 0.0354 0.0712
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0149 0.0221
Trypanosoma brucei glucose transporter, putative 0.0036 0.0354 0.0712
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.3246 0.3229
Schistosoma mansoni importin beta-1 0.003 0.0271 0.0246
Echinococcus multilocularis pyruvate kinase 0.0035 0.0343 0.0319
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0182 0.0333
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.151 0.8782
Plasmodium vivax CDK-related protein kinase 6, putative 0.0491 0.7255 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.2141 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0822 0.0799
Brugia malayi CUB domain containing protein 0.0014 0.0025 0.0076
Onchocerca volvulus 0.0019 0.0102 0.2432
Schistosoma mansoni hypothetical protein 0.0672 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0856 0.1769
Echinococcus multilocularis RUN 0.0019 0.0102 0.0078
Echinococcus granulosus calcium dependent protein kinase 0.0033 0.0314 0.029
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0354 0.0712
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0014 0.0025 0.0076
Echinococcus granulosus pyruvate kinase 0.0035 0.0343 0.0319
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0133 0.1834 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1341 0.4069
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0068
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0102 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0069 0.0028
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0271 0.0454
Schistosoma mansoni protein kinase 0.0035 0.0347 0.0323
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0102 0.0078
Leishmania major GTP-binding protein, putative 0.0022 0.0149 0.0221

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.593 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.028 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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