Detailed information for compound 545681

Basic information

Technical information
  • TDR Targets ID: 545681
  • Name: 2-(4-aminoimidazo[4,5-d]triazin-7-yl)-5-(hydr oxymethyl)tetrahydrofuran-3,4-diol
  • MW: 268.229 | Formula: C9H12N6O4
  • H donors: 4 H acceptors: 7 LogP: -2.81 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1O)O)n1cnc2c1nnnc2N
  • InChi: 1S/C9H12N6O4/c10-7-4-8(13-14-12-7)15(2-11-4)9-6(18)5(17)3(1-16)19-9/h2-3,5-6,9,16-18H,1H2,(H2,10,12,13)
  • InChiKey: JNGWKCBNKZBPLB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-amino-7-imidazo[4,5-d]triazinyl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • 2-(4-azanylimidazo[4,5-d][1,2,3]triazin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • 2-(4-aminoimidazo[4,5-d]triazin-7-yl)-5-methylol-tetrahydrofuran-3,4-diol
  • 2-(4-aminoimidazo[4,5-d]triazin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • 2-azaadenosine
  • 2-(4-aminoimidazo[5,4-d]triazin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • 2-(4-aminoimidazo[5,4-d]triazin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • 2-(4-amino-7-imidazo[5,4-d]triazinyl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • 2-(4-aminoimidazo[5,4-d]triazin-7-yl)-5-methylol-tetrahydrofuran-3,4-diol
  • 2-(4-aminoimidazo[5,4-d][1,2,3]triazin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • 146-94-1
  • 35965-38-9
  • 35965-37-8
  • 56220-48-5
  • NSC178022
  • NSC125640
  • NSC142029
  • NSC142030

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.002 0.0095 0.0076
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0239 0.0512
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0082
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.002 0.0095 0.0076
Brugia malayi intermediate filament protein 0.0022 0.0117 0.025
Trypanosoma brucei RNA helicase, putative 0.0881 1 1
Schistosoma mansoni hypothetical protein 0.0085 0.0845 0.081
Schistosoma mansoni phosphoglucomutase 0.0235 0.2568 0.2539
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0292 0.0255
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0292 0.0343
Onchocerca volvulus 0.0022 0.0117 0.009
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0117 0.025
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0292 0.0549
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0292 0.0343
Trypanosoma brucei unspecified product 0.0255 0.2797 0.2728
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0085 0.0845 0.181
Brugia malayi RNase H family protein 0.0235 0.2568 0.5501
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0117 0.025
Echinococcus granulosus RNA directed DNA polymerase 0.002 0.0095 0.0122
Schistosoma mansoni hypothetical protein 0.0138 0.1448 0.1415
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0037 0.0292 0.0626
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Mycobacterium tuberculosis Possible maturase 0.002 0.0095 0.5
Echinococcus multilocularis RNA directed DNA polymerase 0.002 0.0095 0.0076
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.002 0.0095 0.0076
Onchocerca volvulus Ribonuclease H1 homolog 0.0235 0.2568 1
Schistosoma mansoni scy1(yeast) protein kinase-like 0.002 0.0095 0.0057
Echinococcus multilocularis ribonuclease H1 0.0235 0.2568 0.3418
Brugia malayi RNase H family protein 0.0235 0.2568 0.5501
Brugia malayi Zinc knuckle family protein 0.002 0.0095 0.0203
Trypanosoma brucei ribonuclease H1 0.0235 0.2568 0.2497
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Schistosoma mansoni protein kinase 0.002 0.0095 0.0057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0117 0.025
Brugia malayi RNase H family protein 0.0235 0.2568 0.5501
Loa Loa (eye worm) hypothetical protein 0.0033 0.0239 0.0512
Schistosoma mansoni hypothetical protein 0.002 0.0095 0.0057
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Trypanosoma brucei hypothetical protein, conserved 0.0255 0.2797 0.2728
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Brugia malayi hypothetical protein 0.002 0.0095 0.0203
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0038 0.0082
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.002 0.0095 0.0076
Trypanosoma cruzi ribonuclease H1, putative 0.0235 0.2568 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.002 0.0095 0.0122
Brugia malayi Zinc knuckle family protein 0.002 0.0095 0.0203
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0038 0.0082
Schistosoma mansoni hypothetical protein 0.002 0.0095 0.0057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0037 0.0292 0.0626
Trypanosoma brucei ingi protein (ORF1) 0.0255 0.2797 0.2728
Echinococcus granulosus ribonuclease H1 0.0235 0.2568 0.5464
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0095 0.0057
Giardia lamblia Ribonuclease H 0.0235 0.2568 1
Schistosoma mansoni hypothetical protein 0.0138 0.1448 0.1415
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Echinococcus multilocularis lamin dm0 0.0022 0.0117 0.0106
Echinococcus granulosus KRAB A domain containing protein 0.002 0.0095 0.0122
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Loa Loa (eye worm) hypothetical protein 0.0048 0.0412 0.0883
Schistosoma mansoni phosphoglucomutase 0.0235 0.2568 0.2539
Schistosoma mansoni lamin 0.0022 0.0117 0.0079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0412 0.0883
Brugia malayi hypothetical protein 0.002 0.0095 0.0203
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0292 0.0549
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.002 0.0095 0.0122
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0038 0.0082
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0412 0.0883
Schistosoma mansoni survival motor neuron protein 0.0085 0.0845 0.081
Brugia malayi hypothetical protein 0.0418 0.4668 1
Echinococcus multilocularis musashi 0.0022 0.0117 0.0106
Echinococcus multilocularis survival motor neuron protein 1 0.0418 0.4668 0.6257
Treponema pallidum ribonuclease H (rnhA) 0.0235 0.2568 0.5
Echinococcus multilocularis geminin 0.0138 0.1448 0.1905
Trypanosoma brucei ingi protein (ORF1) 0.0255 0.2797 0.2728
Brugia malayi reverse transcriptase 0.002 0.0095 0.0203
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.002 0.0095 0.0076
Brugia malayi reverse transcriptase 0.002 0.0095 0.0203
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0235 0.2568 0.5
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.002 0.0095 0.0122
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.002 0.0095 0.0076
Trichomonas vaginalis ribonuclease H1, putative 0.0235 0.2568 1
Echinococcus granulosus geminin 0.0138 0.1448 0.3044
Echinococcus granulosus lamin 0.0022 0.0117 0.017
Echinococcus granulosus intermediate filament protein 0.0022 0.0117 0.017
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0659 0.7438 1
Schistosoma mansoni lamin 0.0022 0.0117 0.0079
Echinococcus multilocularis lamin 0.0022 0.0117 0.0106
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.002 0.0095 0.0076
Brugia malayi hypothetical protein 0.002 0.0095 0.0203
Brugia malayi hypothetical protein 0.002 0.0095 0.0203
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.002 0.0095 0.0076
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0412 0.0883
Echinococcus granulosus lamin dm0 0.0022 0.0117 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0292 0.0255
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.002 0.0095 0.0076
Trypanosoma cruzi ribonuclease H1, putative 0.0235 0.2568 1
Onchocerca volvulus 0.0022 0.0117 0.009
Onchocerca volvulus 0.0085 0.0845 0.3033
Brugia malayi reverse transcriptase 0.002 0.0095 0.0203
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.002 0.0095 0.0122
Loa Loa (eye worm) hypothetical protein 0.0022 0.0112 0.0241
Schistosoma mansoni phosphoglucomutase 0.0235 0.2568 0.2539
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.002 0.0095 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0292 0.0255
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0117 0.025
Toxoplasma gondii ribonuclease HI protein 0.0235 0.2568 0.5
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0255 0.2797 0.2728
Loa Loa (eye worm) hypothetical protein 0.0418 0.4668 1
Schistosoma mansoni intermediate filament proteins 0.0022 0.0117 0.0079
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Echinococcus granulosus survival motor neuron protein 1 0.0418 0.4668 1
Leishmania major ribonuclease H1, putative 0.0235 0.2568 0.5
Brugia malayi Pao retrotransposon peptidase family protein 0.002 0.0095 0.0203
Schistosoma mansoni hypothetical protein 0.0033 0.0239 0.0202

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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