Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Homo sapiens | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D2 receptor | 444 aa | 474 aa | 23.4 % |
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.5 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D2 receptor | 444 aa | 432 aa | 30.8 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D2 receptor | 444 aa | 440 aa | 30.0 % |
Schistosoma mansoni | amine GPCR | Dopamine D2 receptor | 444 aa | 424 aa | 32.1 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 428 aa | 31.3 % |
Loa Loa (eye worm) | hypothetical protein | Dopamine D2 receptor | 444 aa | 433 aa | 21.2 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 429 aa | 31.7 % |
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 494 aa | 26.3 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D2 receptor | 444 aa | 456 aa | 29.4 % |
Schistosoma mansoni | biogenic amine receptor | Dopamine D2 receptor | 444 aa | 452 aa | 30.1 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.7 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 487 aa | 23.8 % |
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.0 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 418 aa | 23.0 % | |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Dopamine D2 receptor | 444 aa | 476 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.017 | 0 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0367 | 0.7183 | 0.7183 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.7183 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.017 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.017 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.017 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.017 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.208 | 0.208 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.017 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.017 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.017 | 0 | 0.5 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0367 | 0.7183 | 0.7183 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 1 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Onchocerca volvulus | 0.0367 | 0.7183 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 58 nM | Potency at the sigma binding site was determined in radioligand | ChEMBL. | 1315869 |
IC50 (binding) | = 58 nM | Potency at the sigma binding site was determined in radioligand | ChEMBL. | 1315869 |
IC50 (binding) | = 177 nM | Potency at the sigma binding site was determined in radioligand | ChEMBL. | 1315869 |
IC50 (binding) | = 177 nM | Potency at the sigma binding site was determined in radioligand | ChEMBL. | 1315869 |
Ki (binding) | = 9500 nM | Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum. | ChEMBL. | 1315869 |
Ki (binding) | = 9500 nM | Affinity towards dopamine receptor D2 site was determined by competition studies using [3H]-sulpiride in rat striatum. | ChEMBL. | 1315869 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.