Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0565 | 0.5 |
Brugia malayi | RNA binding protein | 0.0061 | 0.4717 | 0.4591 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0043 | 0.2966 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.4717 | 0.4591 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1958 | 0.1767 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1904 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0565 | 0.0741 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0565 | 0.034 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1904 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1958 | 0.1767 |
Echinococcus multilocularis | dna polymerase eta | 0.0043 | 0.2966 | 0.6096 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4717 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0565 | 0.1904 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0565 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.003 | 0.1711 | 0.4775 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0565 | 0.0741 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.4717 | 0.4591 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0565 | 0.0741 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.4717 | 0.4591 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.3445 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.2966 | 0.2799 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0565 | 0.1904 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0565 | 0.0741 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.003 | 0.1711 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0565 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0043 | 0.2966 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0565 | 0.0741 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.3445 | 0.3289 |
Schistosoma mansoni | DNA polymerase eta | 0.0043 | 0.2966 | 0.6096 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4717 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0565 | 0.1904 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0565 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4717 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1904 |
Leishmania major | DNA polymerase eta, putative | 0.0043 | 0.2966 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.4717 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0565 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0565 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0565 | 0.1904 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0565 | 0.0741 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4717 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.003 | 0.1711 | 0.4775 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1958 | 0.3848 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0043 | 0.2966 | 0.2799 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.4717 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0043 | 0.2966 | 0.6096 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.4717 | 0.4591 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3445 | 0.3289 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4717 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1904 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0565 | 0.034 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.3445 | 0.3289 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1904 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0565 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.4717 | 0.4591 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0565 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Active dose (functional) | = 7.5 mg kg-1 | Compound was tested for active dose in L1210 Leukemia assay; 7.5-60 mg/kg | ChEMBL. | 3735324 |
Active dose (functional) | = 7.5 mg kg-1 | Compound was tested for active dose in L1210 Leukemia assay; 7.5-60 mg/kg | ChEMBL. | 3735324 |
T/C (functional) | = 357 % | Compound was tested for maximum percentage T/C in L1210 Leukemia assay at 60 mg/kg (3 cures out of 6) | ChEMBL. | 3735324 |
T/C (functional) | = 357 % | Compound was tested for maximum percentage T/C in L1210 Leukemia assay at 60 mg/kg (3 cures out of 6) | ChEMBL. | 3735324 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.