Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0121 | 0.0569 | 0.0569 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0127 | 0.0127 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0121 | 0.0569 | 0.0569 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0564 | 0.0564 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0121 | 0.0569 | 0.0569 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0131 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0131 | 0.0322 |
Plasmodium falciparum | steroid dehydrogenase, putative | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0127 | 0.0127 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0131 | 0.112 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0131 | 0.112 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0131 | 0.2306 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0131 | 0.112 |
Giardia lamblia | Oxidoreductase, short chain dehydrogenase/reductase family | 0.0012 | 0 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0797 | 0.4079 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0131 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.0107 | 0.0915 |
Onchocerca volvulus | Huntingtin homolog | 0.0121 | 0.0564 | 0.0564 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0131 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0121 | 0.0569 | 0.0569 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0127 | 0.0127 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0131 | 0.0131 |
Giardia lamblia | Reductase, putative | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0131 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0131 | 0.0322 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.0107 | 0.8169 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0131 | 0.2306 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0131 | 0.2306 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0131 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0131 | 0.0131 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0131 | 0.112 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0131 | 0.112 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0797 | 0.4079 | 0.4079 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0127 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0127 | 0.0311 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0127 | 0.9676 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0131 | 0.0131 |
Brugia malayi | hypothetical protein | 0.0121 | 0.0564 | 0.0564 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0012 | 0 | 0.5 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0131 | 0.0131 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1634 | 0.8426 | 0.8426 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0131 | 0.0131 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0131 | 0.112 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0127 | 0.0127 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0127 | 0.2231 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.011 | 0.0507 | 0.0507 |
Onchocerca volvulus | 0.0037 | 0.0131 | 0.0131 | |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0797 | 0.4079 | 0.4079 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0131 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0797 | 0.4079 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0131 | 0.112 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0131 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0131 | 0.0322 |
Giardia lamblia | Short-chain dehydrogenase, putative | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1937 | 1 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.2055 | 0.2055 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0131 | 0.0131 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0127 | 0.0311 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0127 | 0.0127 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0797 | 0.4079 | 1 |
Onchocerca volvulus | 0.0037 | 0.0131 | 0.0131 | |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0127 | 0.9676 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0131 | 0.112 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0131 | 0.0131 |
Onchocerca volvulus | Huntingtin homolog | 0.0121 | 0.0564 | 0.0564 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0127 | 0.0311 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0121 | 0.0569 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1937 | 1 | 1 |
Plasmodium falciparum | oxidoreductase, short-chain dehydrogenase family, putative | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0127 | 0.9676 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0127 | 0.0311 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0131 | 0.0322 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1937 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0131 | 0.0131 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0121 | 0.0569 | 0.4858 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0131 | 0.0131 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0131 | 0.0131 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0131 | 0.2306 |
Brugia malayi | follicle stimulating hormone receptor | 0.0461 | 0.2334 | 0.2334 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0237 | 0.1171 | 1 |
Giardia lamblia | Hypothetical protein | 0.0012 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0131 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0131 | 1 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0121 | 0.0569 | 0.1394 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0131 | 0.0131 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0127 | 0.0127 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0127 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0131 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0131 | 0.0131 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0127 | 0.9676 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1937 | 1 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1937 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0131 | 0.112 |
Onchocerca volvulus | 0.0037 | 0.0131 | 0.0131 | |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0461 | 0.2334 | 0.2334 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0131 | 0.112 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0121 | 0.0569 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0131 | 0.2306 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.