Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.2303 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0236 | 0.8667 | 0.8667 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.2303 | 0.2303 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0535 | 0.0535 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0535 | 0.0535 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0535 | 0.0618 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.4758 | 0.4758 |
Echinococcus granulosus | lamin | 0.0027 | 0.0535 | 0.0535 |
Leishmania major | hypothetical protein, conserved | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.4126 | 0.4126 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0013 | 0 | 0.5 |
Trypanosoma brucei | calcium-activated potassium channel, putative | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.2303 | 0.2303 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0535 | 0.0535 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.018 | 0.6478 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.2303 | 0.2303 |
Trypanosoma brucei | calcium/potassium channel (CAKC), putative | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.4126 | 0.4126 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0535 | 0.0535 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.018 | 0.6478 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0013 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0236 | 0.8667 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.4126 | 0.476 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.018 | 0.6478 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0013 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.018 | 0.6478 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0535 | 0.0535 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0535 | 0.0535 |
Giardia lamblia | Hypothetical protein | 0.0013 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.2303 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.8995 | 0.8995 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.2303 | 1 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0271 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.0535 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0535 | 0.0535 |
Leishmania major | calcium/potassium channel (CAKC), putative | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0258 | 0.9487 | 0.9487 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0271 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0516 | 0.0516 |
Trypanosoma cruzi | ion transport protein, putative | 0.0013 | 0 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0535 | 0.0618 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0535 | 0.0535 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0049 | 0.0049 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.2303 | 0.2303 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.4217 | 0.4217 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0013 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.018 | 0.6478 | 0.5 |
Leishmania major | potassium channel subunit-like protein | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0013 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.018 | 0.6478 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.018 | 0.6478 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.0535 | 0.0535 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0535 | 0.0535 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.018 | 0.6478 | 1 |
Brugia malayi | hypothetical protein | 0.0073 | 0.2303 | 0.2658 |
Schistosoma mansoni | hypothetical protein | 0.0271 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.2303 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0535 | 0.0535 |
Echinococcus multilocularis | serotonin receptor | 0.0245 | 0.8995 | 0.8995 |
Leishmania major | ion transport protein-like protein | 0.0013 | 0 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0049 | 0.0056 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.018 | 0.6478 | 1 |
Onchocerca volvulus | 0.0027 | 0.0535 | 1 | |
Trypanosoma cruzi | ion transport protein, putative | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0245 | 0.8995 | 0.8995 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.8995 | 0.8995 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0245 | 0.8995 | 0.8995 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 1 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0245 | 0.8995 | 0.8995 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.