TDR Targets

Basic information

Technical information

TDR Targets ID: 563057
Name: copper 1,1,1-trifluoro-4-[2-[(4,4,4-trifluoro -1-methyl-3-oxo-butylidene)amino]ethylimino]p entan-2-one
MW: 393.772 | Formula: C12H12CuF6N2O2
H donors: 0 H acceptors: 2 LogP: 1.83 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CC(=NCC/N=C(/[CH-]C(=O)C(F)(F)F)\C)[CH-]C(=O)C(F)(F)F.[Cu+2]
InChi: 1S/C12H12F6N2O2.Cu/c1-7(5-9(21)11(13,14)15)19-3-4-20-8(2)6-10(22)12(16,17)18;/h5-6H,3-4H2,1-2H3;/q-2;+2/b19-7+,20-8+;
InChiKey: KTBUSJGGPYKNII-XKSVKDSASA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

copper 1,1,1-trifluoro-4-[2-[(4,4,4-trifluoro-1-methyl-3-oxobutylidene)amino]ethylimino]-2-pentanone
copper 1,1,1-trifluoro-4-[2-[(5,5,5-trifluoro-4-oxo-pentan-2-ylidene)amino]ethylimino]pentan-2-one
cupric 1,1,1-trifluoro-4-[2-[(4,4,4-trifluoro-3-keto-1-methyl-butylidene)amino]ethylimino]pentan-2-one
copper 1,1,1-trifluoro-4-[2-[(5,5,5-trifluoro-4-oxopentan-2-ylidene)amino]ethylimino]pentan-2-one
N,N'ethylene bis(trifluoroacetylacetoiminato)copper(II)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.0062	0.069	1
Brugia malayi	Carboxylesterase family protein	0.0383	0.5534	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.069	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0731	0.1321
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0324	0.3258
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0038	0.0324	0.0324
Leishmania major	cathepsin L-like protease	0.0062	0.069	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0324	0.3258
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.022	0.022
Brugia malayi	Carboxylesterase family protein	0.0065	0.0731	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0731	0.1321
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0038	0.0324	0.0324
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.069	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.069	1
Echinococcus multilocularis	GPCR, family 2	0.0031	0.022	0.022
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0065	0.0731	0.0731
Schistosoma mansoni	DNA polymerase eta	0.0038	0.0324	0.0324
Echinococcus granulosus	neuroligin	0.0065	0.0731	0.0731
Schistosoma mansoni	hypothetical protein	0.0031	0.022	0.022
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0065	0.0731	0.0731
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.069	1
Echinococcus granulosus	acetylcholinesterase	0.0383	0.5534	0.5534
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.022	0.0397
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.069	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0065	0.0731	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0324	0.3258
Mycobacterium ulcerans	carboxylesterase, LipT	0.0065	0.0731	1
Leishmania major	DNA polymerase kappa, putative	0.0038	0.0324	0.4697
Loa Loa (eye worm)	carboxylesterase	0.0065	0.0731	0.1321
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0324	0.3258
Plasmodium vivax	vivapain-2	0.0016	0	0.5
Onchocerca volvulus		0.0065	0.0731	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0324	0.3258
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0	0.5
Onchocerca volvulus		0.0065	0.0731	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.022	0.0397
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0324	0.3258
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.1225	0.2214
Schistosoma mansoni	hypothetical protein	0.0031	0.022	0.022
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.069	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0	0.5
Trypanosoma brucei	unspecified product	0.0038	0.0324	0.3258
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.049	0.7098
Schistosoma mansoni	BC026374 protein (S09 family)	0.0065	0.0731	0.0731
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.069	1
Loa Loa (eye worm)	carboxylesterase	0.0383	0.5534	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0038	0.0324	0.0585
Schistosoma mansoni	gliotactin	0.0065	0.0731	0.0731
Leishmania major	DNA polymerase eta, putative	0.0038	0.0324	0.4697
Echinococcus granulosus	GPCR family 2	0.0031	0.022	0.022
Schistosoma mansoni	acetylcholinesterase	0.0065	0.0731	0.0731
Echinococcus multilocularis	dna polymerase kappa	0.0038	0.0324	0.0324
Echinococcus granulosus	dna polymerase kappa	0.0038	0.0324	0.0324
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0324	0.3258
Echinococcus granulosus	dna polymerase eta	0.0038	0.0324	0.0324
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0038	0.0324	1
Echinococcus multilocularis	carboxylesterase 5A	0.0383	0.5534	0.5534
Schistosoma mansoni	microtubule-associated protein tau	0.0679	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.069	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0065	0.0731	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0731	0.1321
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0324	0.4697
Brugia malayi	ImpB/MucB/SamB family protein	0.0038	0.0324	0.0585
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0324	0.4697
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0731	0.1321
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0	0.5
Trichomonas vaginalis	spcc417.12 protein, putative	0.0065	0.0731	1
Schistosoma mansoni	hypothetical protein	0.0031	0.022	0.022
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0065	0.0731	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.069	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0731	0.1321
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0324	0.3258
Loa Loa (eye worm)	acetylcholinesterase 1	0.0383	0.5534	1
Plasmodium vivax	vivapain-2	0.0016	0	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0324	0.3258
Echinococcus multilocularis	microtubule associated protein 2	0.0679	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.1225	0.2214
Toxoplasma gondii	cathepsin CPL	0.0016	0	0.5
Echinococcus granulosus	para nitrobenzyl esterase	0.0065	0.0731	0.0731
Loa Loa (eye worm)	carboxylesterase	0.0065	0.0731	0.1321
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.022	0.022
Echinococcus multilocularis	dna polymerase eta	0.0038	0.0324	0.0324
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0065	0.0731	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0065	0.0731	0.0731
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0324	0.4697
Echinococcus multilocularis	acetylcholinesterase	0.0383	0.5534	0.5534
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0065	0.0731	1
Echinococcus multilocularis	para nitrobenzyl esterase	0.0065	0.0731	0.0731
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0324	0.3258
Onchocerca volvulus		0.0065	0.0731	1
Schistosoma mansoni	hypothetical protein	0.0167	0.227	0.227
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0038	0.0324	0.0324
Giardia lamblia	DINP protein human, muc B family	0.0038	0.0324	0.5
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0324	0.3258
Echinococcus multilocularis	acetylcholinesterase	0.0383	0.5534	0.5534
Echinococcus multilocularis	geminin	0.0167	0.227	0.227
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0038	0.0324	0.4431
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1225	0.2214
Brugia malayi	Carboxylesterase family protein	0.0383	0.5534	1
Schistosoma mansoni	hypothetical protein	0.0067	0.076	0.076
Trichomonas vaginalis	DNA polymerase eta, putative	0.0038	0.0324	0.4431
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0731	0.1321
Brugia malayi	hypothetical protein	0.0065	0.0731	0.1321
Schistosoma mansoni	hypothetical protein	0.0031	0.022	0.022
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.069	1
Loa Loa (eye worm)	hypothetical protein	0.0383	0.5534	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.069	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0383	0.5534	0.5534
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.022	0.022
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0609	0.8824
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.1225	0.2214
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.076	0.1373
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0324	0.3258
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.022	0.0397
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.069	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.069	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0324	0.4697
Echinococcus granulosus	geminin	0.0167	0.227	0.227
Echinococcus granulosus	carboxylesterase 5A	0.0383	0.5534	0.5534
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0731	0.1321
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0038	0.0324	0.0324
Trypanosoma brucei	DNA polymerase eta, putative	0.0038	0.0324	0.3258
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.069	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0038	0.0324	0.4697
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0065	0.0731	0.0731
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.022	0.022
Brugia malayi	Carboxylesterase family protein	0.0065	0.0731	0.1321
Leishmania major	cathepsin L-like protease	0.0062	0.069	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0324	0.3258
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0065	0.0731	0.0731
Brugia malayi	Carboxylesterase family protein	0.0065	0.0731	0.1321
Brugia malayi	ImpB/MucB/SamB family protein	0.0038	0.0324	0.0585
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0038	0.0324	0.4697
Onchocerca volvulus		0.0065	0.0731	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.022	0.0397
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0065	0.0731	0.0731
Echinococcus granulosus	acetylcholinesterase	0.0383	0.5534	0.5534
Brugia malayi	Carboxylesterase family protein	0.0065	0.0731	0.1321
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.069	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.076	0.1373
Echinococcus granulosus	BC026374 protein S09 family	0.0065	0.0731	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0383	0.5534	1
Schistosoma mansoni	hypothetical protein	0.0167	0.227	0.227
Echinococcus multilocularis	neuroligin	0.0065	0.0731	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0324	0.0585
Onchocerca volvulus		0.0065	0.0731	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 24182636

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 563057