Detailed information for compound 564276

Basic information

Technical information
  • TDR Targets ID: 564276
  • Name: [5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyrid yl]methyl phosphate
  • MW: 247.142 | Formula: C8H10NO6P--
  • H donors: 2 H acceptors: 6 LogP: -1.58 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1c(cnc(c1O)C)COP(=O)([O-])[O-]
  • InChi: 1S/C8H12NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2,10-11H,3-4H2,1H3,(H2,12,13,14)/p-2
  • InChiKey: WHOMFKWHIQZTHY-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • [5-hydroxy-4-(hydroxymethyl)-6-methyl-pyridin-3-yl]methyl phosphate
  • (5-hydroxy-6-methyl-4-methylol-3-pyridyl)methyl phosphate
  • [5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methyl phosphate
  • pyridoxine 5-phosphate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0123 0.0087 0.3908
Leishmania major nucleoside transporter 1, putative 0.0123 0.0087 0.5
Trypanosoma cruzi nucleoside transporter-like, putative 0.0123 0.0087 0.5
Treponema pallidum methionyl-tRNA synthetase 0.0266 0.0258 0.5
Toxoplasma gondii nucleoside transporter protein 0.0123 0.0087 0.0068
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0123 0.0087 0.5
Schistosoma mansoni protein kinase 0.0123 0.0087 0.3908
Loa Loa (eye worm) hypothetical protein 0.0123 0.0087 0.3908
Loa Loa (eye worm) hypothetical protein 0.0123 0.0087 0.3908
Leishmania major nucleoside transporter 1, putative 0.0123 0.0087 0.5
Trypanosoma brucei adenosine transporter, putative 0.8441 1 1
Trypanosoma cruzi nucleoside transporter 1, putative 0.0123 0.0087 0.5
Brugia malayi hypothetical protein 0.0123 0.0087 0.339
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0123 0.0087 0.5
Loa Loa (eye worm) hypothetical protein 0.0123 0.0087 0.3908
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0123 0.0087 0.5
Leishmania major nucleobase transporter 0.0123 0.0087 0.5
Brugia malayi hypothetical protein 0.0123 0.0087 0.339
Chlamydia trachomatis methionine--tRNA ligase 0.0237 0.0223 0.5
Toxoplasma gondii nucleoside transporter protein 0.0123 0.0087 0.0068
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0123 0.0087 0.5
Giardia lamblia Hypothetical protein 0.0123 0.0087 0.5
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0123 0.0087 0.3908
Echinococcus granulosus equilibrative nucleoside transporter 0.0123 0.0087 0.3908
Schistosoma mansoni methionine-tRNA synthetase 0.0237 0.0223 1
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0123 0.0087 0.5
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0123 0.0087 0.3908
Leishmania major nucleobase transporter 0.0123 0.0087 0.5
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0266 0.0258 1
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0237 0.0223 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.0223 1
Brugia malayi methionyl-tRNA synthetase 0.0266 0.0258 1
Trypanosoma cruzi nucleoside transporter 1, putative 0.0123 0.0087 0.5
Brugia malayi Nucleoside transporter family protein 0.0123 0.0087 0.339
Trypanosoma cruzi nucleoside transporter 1, putative 0.0123 0.0087 0.5
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0123 0.0087 0.5
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0123 0.0087 0.5
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0123 0.0087 0.3908
Trypanosoma cruzi nucleobase transporter, putative 0.0123 0.0087 0.5
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0123 0.0087 0.5
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0237 0.0223 1
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0123 0.0087 0.5
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0123 0.0087 0.5
Schistosoma mansoni equilibrative nucleoside transporter 0.0123 0.0087 0.3908
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0123 0.0087 0.5
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0228 0.0213 0.9511
Trypanosoma cruzi nucleobase transporter, putative 0.0123 0.0087 0.5
Trypanosoma cruzi nucleoside transporter-like, putative 0.0123 0.0087 0.5
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0123 0.0087 0.5
Trypanosoma cruzi nucleobase transporter, putative 0.0123 0.0087 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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