Detailed information for compound 56481

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 512.676 | Formula: C28H48O8
  • H donors: 3 H acceptors: 5 LogP: 3.84 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)CCCCCCCCCC(=O)/C=C(/C[C@@H]1OCC([C@H]([C@H]1O)O)C[C@@H]1O[C@H]1[C@H]([C@@H](O)C)C)\C
  • InChi: 1S/C28H48O8/c1-18(14-22(30)12-10-8-6-5-7-9-11-13-25(31)34-4)15-23-27(33)26(32)21(17-35-23)16-24-28(36-24)19(2)20(3)29/h14,19-21,23-24,26-29,32-33H,5-13,15-17H2,1-4H3/b18-14+/t19-,20-,21?,23-,24-,26+,27-,28-/m0/s1
  • InChiKey: GVHRBOUPIQHONH-BYELCHMPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli isoleucyl-tRNA synthetase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126684 All targets in OG5_126684
Babesia bovis isoleucyl-tRNA synthetase family protein Get druggable targets OG5_126684 All targets in OG5_126684
Mycobacterium tuberculosis Isoleucyl-tRNA synthetase IleS Get druggable targets OG5_126684 All targets in OG5_126684
Plasmodium yoelii isoleucyl-tRNA synthetase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Leishmania mexicana isoleucyl-tRNA synthetase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Schistosoma mansoni isoleucine--tRNA ligase Get druggable targets OG5_126684 All targets in OG5_126684
Candida albicans likely tRNA synthetase similar to S. cerevisiae ISM1 (YPL040C) nuclear encoded mitochondrial tRNA-Ile synthetase Get druggable targets OG5_126684 All targets in OG5_126684
Plasmodium berghei isoleucine--tRNA ligase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Echinococcus multilocularis isoleucyl tRNA synthetase, cytoplasmic Get druggable targets OG5_126684 All targets in OG5_126684
Mycobacterium leprae isoleucyl-tRNA synthetase IleS Get druggable targets OG5_126684 All targets in OG5_126684
Leishmania major isoleucyl-tRNA synthetase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Trypanosoma cruzi isoleucyl-tRNA synthetase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Leishmania donovani isoleucyl-tRNA synthetase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Schistosoma mansoni isoleucine--tRNA ligase Get druggable targets OG5_126684 All targets in OG5_126684
Candida albicans probable tRNA synthetase similar to S. cerevisiae ILS1 (YBL076C) Isoleucyl-tRNA synthetase, cytoplasmic Get druggable targets OG5_126684 All targets in OG5_126684
Mycobacterium ulcerans isoleucyl-tRNA synthetase Get druggable targets OG5_126684 All targets in OG5_126684
Echinococcus granulosus isoleucyl tRNA synthetase, cytoplasmic Get druggable targets OG5_126684 All targets in OG5_126684
Theileria parva isoleucyl-tRNA synthetase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Echinococcus granulosus isoleucyl trna synthetase mitochondrial Get druggable targets OG5_126684 All targets in OG5_126684
Loa Loa (eye worm) isoleucyl-tRNA synthetase Get druggable targets OG5_126684 All targets in OG5_126684
Trypanosoma brucei isoleucyl-tRNA synthetase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Entamoeba histolytica isoleucyl-tRNA synthetase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Plasmodium vivax isoleucine--tRNA ligase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Neospora caninum isoleucine-tRNA synthetase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126684 All targets in OG5_126684
Chlamydia trachomatis isoleucine--tRNA ligase Get druggable targets OG5_126684 All targets in OG5_126684
Plasmodium knowlesi isoleucine--tRNA ligase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Echinococcus multilocularis isoleucyl tRNA synthetase, mitochondrial Get druggable targets OG5_126684 All targets in OG5_126684
Schistosoma japonicum ko:K01870 isoleucyl-tRNA synthetase [EC6.1.1.5], putative Get druggable targets OG5_126684 All targets in OG5_126684
Schistosoma japonicum ko:K01870 isoleucyl-tRNA synthetase [EC6.1.1.5], putative Get druggable targets OG5_126684 All targets in OG5_126684
Toxoplasma gondii isoleucyl-tRNA synthetase family protein Get druggable targets OG5_126684 All targets in OG5_126684
Cryptosporidium parvum isoleucine-tRNA synthetase Get druggable targets OG5_126684 All targets in OG5_126684
Trypanosoma brucei gambiense isoleucyl-tRNA synthetase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Cryptosporidium hominis isoleucine-tRNA synthetase Get druggable targets OG5_126684 All targets in OG5_126684
Schistosoma japonicum ko:K01870 isoleucyl-tRNA synthetase [EC6.1.1.5], putative Get druggable targets OG5_126684 All targets in OG5_126684
Wolbachia endosymbiont of Brugia malayi isoleucyl-tRNA synthetase Get druggable targets OG5_126684 All targets in OG5_126684
Treponema pallidum isoleucyl-tRNA synthetase Get druggable targets OG5_126684 All targets in OG5_126684
Leishmania infantum isoleucyl-tRNA synthetase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Trichomonas vaginalis isoleucyl tRNA synthetase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Giardia lamblia Isoleucyl-tRNA synthetase Get druggable targets OG5_126684 All targets in OG5_126684
Brugia malayi isoleucyl-tRNA synthetase Get druggable targets OG5_126684 All targets in OG5_126684
Leishmania braziliensis isoleucyl-tRNA synthetase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Candida albicans probable tRNA synthetase similar to S. cerevisiae ILS1 (YBL076C) Isoleucyl-tRNA synthetase, cytoplasmic Get druggable targets OG5_126684 All targets in OG5_126684
Candida albicans likely tRNA synthetase similar to S. cerevisiae ISM1 (YPL040C) nuclear encoded mitochondrial tRNA-Ile synthetase Get druggable targets OG5_126684 All targets in OG5_126684
Babesia bovis tRNA synthetases class I protein superfamily Get druggable targets OG5_126684 All targets in OG5_126684
Schistosoma japonicum ko:K01870 isoleucyl-tRNA synthetase [EC6.1.1.5], putative Get druggable targets OG5_126684 All targets in OG5_126684
Plasmodium falciparum isoleucine--tRNA ligase, putative Get druggable targets OG5_126684 All targets in OG5_126684
Brugia malayi isoleucyl-tRNA synthetase family protein Get druggable targets OG5_126684 All targets in OG5_126684
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126684 All targets in OG5_126684
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi tailless protein 0.005 0.2549 0.2458
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0106 0.8256 1
Schistosoma mansoni nuclear receptor 0.005 0.2549 0.2458
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0106 0.8256 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0056 0.316 0.3828
Echinococcus multilocularis ecdysone induced protein 78C 0.0106 0.8256 1
Brugia malayi Nuclear hormone receptor E75 0.005 0.2549 0.2458
Wolbachia endosymbiont of Brugia malayi formamidopyrimidine-DNA glycosylase 0.0112 0.8853 1
Loa Loa (eye worm) nuclear hormone receptor 0.005 0.2549 0.3087
Giardia lamblia Isoleucyl-tRNA synthetase 0.0032 0.0689 0.5
Echinococcus granulosus FTZ F1 alpha 0.0106 0.8256 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0106 0.8256 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.316 0.3828
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.2549 0.3087
Chlamydia trachomatis isoleucine--tRNA ligase 0.0032 0.0689 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0056 0.316 0.3828
Brugia malayi nuclear receptor NHR-67 0.005 0.2549 0.2458
Echinococcus multilocularis FTZ F1 alpha 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.005 0.2549 0.3087
Plasmodium vivax isoleucine--tRNA ligase, putative 0.0032 0.0689 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0106 0.8256 1
Brugia malayi ecdysteroid receptor 0.0106 0.8256 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0106 0.8256 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.005 0.2549 0.2458
Loa Loa (eye worm) hypothetical protein 0.0032 0.0689 0.0834
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0106 0.8256 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0106 0.8256 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0106 0.8256 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0106 0.8256 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0106 0.8256 1
Toxoplasma gondii isoleucyl-tRNA synthetase family protein 0.0032 0.0689 0.5
Brugia malayi nuclear hormone receptor family member odr-7 0.005 0.2549 0.2458
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0106 0.8256 1
Onchocerca volvulus 0.005 0.2549 0.3087
Brugia malayi steroid hormone receptor 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.005 0.2549 0.3087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.005 0.2549 0.3087
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0106 0.8256 1
Loa Loa (eye worm) isoleucyl-tRNA synthetase 0.0032 0.0689 0.0834
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0106 0.8256 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0106 0.8256 1
Echinococcus granulosus thyroid hormone receptor alpha 0.005 0.2549 0.3087
Echinococcus multilocularis isoleucyl tRNA synthetase, cytoplasmic 0.0032 0.0689 0.0834
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.2549 0.3087
Loa Loa (eye worm) nuclear receptor nhr-7B 0.005 0.2549 0.3087
Loa Loa (eye worm) hypothetical protein 0.005 0.2549 0.3087
Schistosoma mansoni steroid hormone receptor ad4bp 0.0106 0.8256 1
Schistosoma mansoni zinc finger protein 0.005 0.2549 0.2458
Loa Loa (eye worm) hypothetical protein 0.0106 0.8256 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.005 0.2549 0.2458
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.316 0.3266
Loa Loa (eye worm) hypothetical protein 0.005 0.2549 0.3087
Brugia malayi hypothetical protein 0.0056 0.316 0.3266
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0112 0.8853 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0106 0.8256 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.2549 0.3087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0106 0.8256 1
Mycobacterium tuberculosis Possible DNA glycosylase 0.0112 0.8853 0.5
Schistosoma mansoni nuclear receptor nhr-48 0.005 0.2549 0.2458
Loa Loa (eye worm) nuclear receptor NHR-67 0.005 0.2549 0.3087
Brugia malayi nuclear receptor NHR-88 0.005 0.2549 0.2458
Mycobacterium tuberculosis Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) 0.0112 0.8853 0.5
Schistosoma mansoni nuclear hormone receptor 0.005 0.2549 0.2458
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.005 0.2549 0.3087
Schistosoma mansoni nuclear hormone receptor 0.0106 0.8256 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.005 0.2549 0.3087
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.2549 0.3087
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0106 0.8256 1
Brugia malayi ecdysone receptor 0.005 0.2549 0.2458
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.316 0.3266
Echinococcus granulosus isoleucyl tRNA synthetase, cytoplasmic 0.0032 0.0689 0.0834
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0106 0.8256 1
Brugia malayi conserved hypotetical protein 0.005 0.2549 0.2458
Loa Loa (eye worm) hypothetical protein 0.0106 0.8256 1
Schistosoma mansoni RAR-like nuclear receptor 0.0106 0.8256 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0106 0.8256 1
Brugia malayi hypothetical protein 0.0056 0.316 0.3266
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.2549 0.3087
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0106 0.8256 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0106 0.8256 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.2549 0.3087
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0106 0.8256 1
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.316 0.3266
Trypanosoma cruzi isoleucyl-tRNA synthetase, putative 0.0032 0.0689 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.316 0.3828
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.005 0.2549 0.3087
Echinococcus granulosus ecdysone induced protein 78C 0.0106 0.8256 1
Brugia malayi orphan nuclear receptor NR2E1 0.005 0.2549 0.2458
Brugia malayi nuclear receptor NHR-88 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.316 0.3828
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0106 0.8256 1
Brugia malayi hypothetical protein 0.005 0.2549 0.2458
Brugia malayi Nuclear hormone receptor E75 0.005 0.2549 0.2458
Schistosoma mansoni coup transcription factor 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.005 0.2549 0.3087
Brugia malayi photoreceptor-specific nuclear receptor 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.005 0.2549 0.3087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.2549 0.3087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0106 0.8256 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0106 0.8256 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.005 0.2549 0.2458
Loa Loa (eye worm) hypothetical protein 0.0106 0.8256 1
Schistosoma mansoni thyroid hormone receptor 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.8256 1
Schistosoma mansoni thyroid hormone receptor 0.0106 0.8256 1
Trichomonas vaginalis isoleucyl tRNA synthetase, putative 0.0032 0.0689 0.5
Leishmania major isoleucyl-tRNA synthetase, putative 0.0032 0.0689 0.5
Mycobacterium leprae Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) 0.0112 0.8853 1
Treponema pallidum isoleucyl-tRNA synthetase 0.0032 0.0689 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0106 0.8256 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0106 0.8256 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0106 0.8256 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0106 0.8256 1
Brugia malayi nuclear hormone receptor 0.0106 0.8256 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.005 0.2549 0.3087
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0106 0.8256 1
Brugia malayi Nuclear hormone receptor-like 1 0.0106 0.8256 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.005 0.2549 0.2458
Loa Loa (eye worm) hypothetical protein 0.005 0.2549 0.3087
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0106 0.8256 1
Trypanosoma brucei isoleucyl-tRNA synthetase, putative 0.0032 0.0689 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0106 0.8256 1
Brugia malayi hypothetical protein 0.005 0.2549 0.2458
Brugia malayi Steroid receptor seven-up type 2 0.0106 0.8256 1
Echinococcus granulosus nuclear receptor nhr 48 0.005 0.2549 0.3087
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.005 0.2549 0.3087
Loa Loa (eye worm) hypothetical protein 0.0056 0.316 0.3828
Loa Loa (eye worm) hypothetical protein 0.0056 0.316 0.3828
Onchocerca volvulus 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.8256 1
Loa Loa (eye worm) DR-78 0.005 0.2549 0.3087
Echinococcus multilocularis nuclear receptor nhr 48 0.005 0.2549 0.3087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.8256 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0106 0.8256 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0056 0.316 0.3828
Brugia malayi nuclear receptor RXR 0.005 0.2549 0.2458
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0106 0.8256 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0106 0.8256 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0106 0.8256 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0106 0.8256 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.8256 1
Schistosoma mansoni nuclear hormone receptor 0.005 0.2549 0.2458
Entamoeba histolytica isoleucyl-tRNA synthetase, putative 0.0032 0.0689 0.5
Brugia malayi nuclear receptor RXR 0.0056 0.316 0.3266
Loa Loa (eye worm) hypothetical protein 0.005 0.2549 0.3087
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0112 0.8853 1
Loa Loa (eye worm) hypothetical protein 0.005 0.2549 0.3087
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0106 0.8256 1
Schistosoma mansoni retinoic acid receptor RXR 0.0106 0.8256 1
Schistosoma mansoni nuclear receptor 0.005 0.2549 0.2458
Brugia malayi nuclear hormone receptor 0.005 0.2549 0.2458
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.2549 0.3087
Loa Loa (eye worm) hypothetical protein 0.005 0.2549 0.3087
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0056 0.316 0.3266
Onchocerca volvulus Bile acid receptor homolog 0.0106 0.8256 1
Onchocerca volvulus 0.005 0.2549 0.3087

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.7 ug ml-1 Inhibitory activity against Isoleucyl-tRNA synthetase ChEMBL. 2491891
IC50 (binding) = 1.7 ug ml-1 Inhibitory activity against Isoleucyl-tRNA synthetase ChEMBL. 2491891
MIC (functional) = 0.05 ug ml-1 In vitro antibacterial activity against Escherichia coli SS ChEMBL. 2491891
MIC (functional) = 0.05 ug ml-1 In vitro antibacterial activity against Escherichia coli SS ChEMBL. 2491891
MIC (functional) = 0.1 ug ml-1 In vitro antibacterial activity against Streptococcus pyogenes EES 61 ChEMBL. 2491891
MIC (functional) = 0.39 ug ml-1 In vitro antibacterial activity against Staphylococcus aureus ATCC 6535P ChEMBL. 2491891
MIC (functional) = 0.39 ug ml-1 In vitro antibacterial activity against Staphylococcus epidermidis 3519 ChEMBL. 2491891
MIC (functional) = 3.1 ug ml-1 In vitro antibacterial activity against Streptococcus agalactiae CMX 508 ChEMBL. 2491891
MIC (functional) = 50 ug ml-1 In vitro antibacterial activity against Escherichia coli Juhl ChEMBL. 2491891
MIC (functional) = 50 ug ml-1 In vitro antibacterial activity against Escherichia coli Juhl ChEMBL. 2491891

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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