Detailed information for compound 570830

Basic information

Technical information
  • TDR Targets ID: 570830
  • Name: 1-(4-azidophenyl)-2-bromo-ethanone
  • MW: 241.065 | Formula: C8H7BrN3O
  • H donors: 0 H acceptors: 1 LogP: 3.33 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [NH-]=[N+]=Nc1ccc(cc1)C(=O)CBr
  • InChi: 1S/C8H6BrN3O/c9-5-8(13)6-1-3-7(4-2-6)11-12-10/h1-4H,5H2
  • InChiKey: LZJPDRANSVSGOR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-azidophenyl)-2-bromoethanone
  • 4-azidophenacyl bromide
  • 57018-46-9
  • 4-Azido-alpha-bromoacetophenone
  • A6057_SIGMA
  • Ethanone, 1-(4-azidophenyl)-2-bromo-
  • 1-(4-Azidophenyl)-2-bromoethan-1-one
  • EINECS 260-519-5
  • 4'-Azido-2-bromoacetophenone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.3206 0.8539
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0028 0.0583 0.0583
Onchocerca volvulus 0.0073 0.3754 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.3206 0.3206
Trypanosoma brucei endonuclease G, putative 0.002 0 0.5
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0034 0.0962 0.2563
Loa Loa (eye worm) hypothetical protein 0.0034 0.0962 0.0402
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.3206 1
Echinococcus multilocularis muscleblind protein 1 0.0161 1 1
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0073 0.3754 0.3368
Brugia malayi Thrombospondin type 1 domain containing protein 0.0073 0.3754 0.3754
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.002 0 0.5
Echinococcus multilocularis muscleblind protein 0.0161 1 1
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0034 0.0962 0.0962
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0962 0.0962
Echinococcus granulosus muscleblind protein 0.0161 1 1
Trypanosoma cruzi endonuclease G, putative 0.002 0 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.2058 0.2058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.2058 0.2058
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0962 0.0962
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0034 0.0962 0.2563
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.2058 0.1566
Loa Loa (eye worm) hypothetical protein 0.0161 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0962 0.0402
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.2058 0.2058
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0962 0.0962
Trypanosoma brucei endonuclease G, putative 0.002 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0161 1 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0962 0.0962
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0962 0.0962
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0962 0.0962
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0962 0.0962
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.3206 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.3206 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.2058 0.5481
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0034 0.0962 0.2563
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.3206 0.3206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.2058 0.5481
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0034 0.0962 0.2563
Trypanosoma cruzi endonuclease G, putative 0.002 0 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.3206 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0962 0.0402
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.2058 0.2058
Echinococcus multilocularis ectonucleotide 0.0028 0.0583 0.0583
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0962 0.0962
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.3206 0.8539
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0962 0.0962
Trypanosoma brucei endonuclease G, putative 0.002 0 0.5
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0962 0.0962
Echinococcus granulosus ectonucleotide 0.0028 0.0583 0.0583
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.2058 0.2058
Schistosoma mansoni hypothetical protein 0.0073 0.3754 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.0962 0.0962
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.3206 0.5
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0028 0.0583 0.0583
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.002 0 0.5
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.3206 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.2058 0.5481

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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