Detailed information for compound 570968

Basic information

Technical information
  • TDR Targets ID: 570968
  • Name: 2-(3-hydroxyphenyl)-3-(4-oxo-2-phenyl-quinazo lin-3-yl)thiazolidin-4-one
  • MW: 415.464 | Formula: C23H17N3O3S
  • H donors: 1 H acceptors: 3 LogP: 3.95 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cccc(c1)C1SCC(=O)N1n1c(nc2c(c1=O)cccc2)c1ccccc1
  • InChi: 1S/C23H17N3O3S/c27-17-10-6-9-16(13-17)23-25(20(28)14-30-23)26-21(15-7-2-1-3-8-15)24-19-12-5-4-11-18(19)22(26)29/h1-13,23,27H,14H2
  • InChiKey: UPNWCRIXMTZEHQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-hydroxyphenyl)-3-(4-oxo-2-phenyl-3-quinazolinyl)-4-thiazolidinone
  • 2-(3-hydroxyphenyl)-3-(4-oxo-2-phenyl-quinazolin-3-yl)-1,3-thiazolidin-4-one
  • 2-(3-hydroxyphenyl)-3-(4-keto-2-phenyl-quinazolin-3-yl)thiazolidin-4-one
  • 2-(3-hydroxyphenyl)-3-(4-oxo-2-phenylquinazolin-3-yl)-1,3-thiazolidin-4-one
  • 3-[2-(3-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl]-2-phenylquinazolin-4-one
  • 3-[2-(3-hydroxyphenyl)-4-oxo-thiazolidin-3-yl]-2-phenyl-quinazolin-4-one
  • 3-[2-(3-hydroxyphenyl)-4-oxo-3-thiazolidinyl]-2-phenyl-4-quinazolinone
  • 3-[2-(3-hydroxyphenyl)-4-keto-thiazolidin-3-yl]-2-phenyl-quinazolin-4-one
  • 3-[2-(3-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl]-2-phenyl-quinazolin-4-one
  • 106873-19-2
  • 4(3H)-Quinazolinone, 3-(2-(3-hydroxyphenyl)-4-oxo-3-thiazolidinyl)-2-phenyl-
  • BRN 5643118
  • 3-(2-(3-Hydroxyphenyl)-4-oxo-3-thiazolidinyl)-2-phenyl-4(3H)-quinazolinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0578 0.0578
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0578 0.0958
Brugia malayi Metabotropic glutamate receptor precursor. 0.0039 0.0247 0.0541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2277 0.2277
Echinococcus granulosus metabotropic glutamate receptor 5 0.0049 0.06 0.0994
Entamoeba histolytica glycogen phosphorylase, putative 0.0104 0.2754 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0835 0.1383
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0835 0.1383
Echinococcus multilocularis glycogen phosphorylase 0.0104 0.2754 0.4564
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0045 0.0466 0.5
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0835 0.0835
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0835 0.1383
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0835 0.1383
Echinococcus granulosus glycogen phosphorylase 0.0104 0.2754 0.4564
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0578 0.0958
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.2277 0.3774
Echinococcus granulosus glycogen phosphorylase 0.0104 0.2754 0.4564
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0578 0.1318
Loa Loa (eye worm) glycogen phosphorylase 0.0104 0.2754 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0578 0.0958
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.2277 0.3774
Trichomonas vaginalis glycogen phosphorylase, putative 0.0104 0.2754 0.5
Brugia malayi mbt repeat family protein 0.0048 0.0578 0.1788
Schistosoma mansoni glycogen phosphorylase 0.0045 0.0466 0.0466
Echinococcus multilocularis glycogen phosphorylase 0.0104 0.2754 0.4564
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0045 0.0456 0.0456
Onchocerca volvulus Glycogen phosphorylase homolog 0.0104 0.2754 1
Brugia malayi mbt repeat family protein 0.0048 0.0578 0.1788
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0045 0.0466 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.06 0.1406
Brugia malayi carbohydrate phosphorylase 0.0104 0.2754 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0578 0.1318
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2277 0.2277
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0578 0.0578
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0049 0.06 0.0994
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.2277 0.3774
Chlamydia trachomatis glycogen phosphorylase 0.0104 0.2754 0.5
Trichomonas vaginalis glycogen phosphorylase, putative 0.0104 0.2754 0.5
Echinococcus granulosus Glycosyl transferase family 35 0.0104 0.2754 0.4564
Giardia lamblia Glycogen phosphorylase 0.0104 0.2754 0.5
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0578 0.0958
Schistosoma mansoni glycogen phosphorylase 0.0104 0.2754 0.2754
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.6033 1
Schistosoma mansoni glycogen phosphorylase 0.0104 0.2754 0.2754
Loa Loa (eye worm) MBCTL1 0.0055 0.0835 0.2343
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.6033 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2277 0.2277
Entamoeba histolytica glycogen phosphorylase, putative 0.0104 0.2754 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.2277 0.8097
Loa Loa (eye worm) hypothetical protein 0.0055 0.0835 0.2343
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0578 0.0578
Echinococcus multilocularis Glycosyl transferase, family 35 0.0104 0.2754 0.4564
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.2277 0.3774
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0835 0.2757
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.2277 0.82

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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