Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0757 | 0.1008 | 0.0936 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3671 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0858 | 0.132 | 0.1255 |
Loa Loa (eye worm) | hypothetical protein | 0.3671 | 1 | 1 |
Schistosoma mansoni | Mername-AA248 (C02 family) | 0.0632 | 0.0622 | 0.0546 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0757 | 0.1008 | 0.0941 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3671 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0757 | 0.1008 | 0.1008 |
Loa Loa (eye worm) | calpain family protein 1 | 0.1705 | 0.3934 | 0.3889 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0858 | 0.132 | 0.4902 |
Leishmania major | cysteine peptidase A (CPA) | 0.1278 | 0.2616 | 0.8983 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3671 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0757 | 0.1008 | 0.1008 |
Echinococcus granulosus | cathepsin l1 | 0.0858 | 0.132 | 0.0745 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Loa Loa (eye worm) | calpain | 0.0632 | 0.0622 | 0.0552 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Onchocerca volvulus | Cathepsin L homolog | 0.1278 | 0.2616 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1278 | 0.2616 | 0.2127 |
Echinococcus granulosus | cathepsin b | 0.3671 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.0622 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Giardia lamblia | Cathepsin B precursor | 0.1368 | 0.2894 | 0.5 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0858 | 0.132 | 0.1255 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.0632 | 0.0622 | 0.0546 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.0622 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.183 | 0.4319 | 0.4274 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1278 | 0.2616 | 0.2616 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1278 | 0.2616 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0632 | 0.0622 | 0.0622 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Brugia malayi | Cathepsin L-like precursor | 0.1278 | 0.2616 | 0.2561 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.132 | 0.1255 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1368 | 0.2894 | 0.2894 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0632 | 0.0622 | 0.0622 |
Echinococcus multilocularis | cathepsin L | 0.0757 | 0.1008 | 0.0412 |
Loa Loa (eye worm) | cysteine protease | 0.1278 | 0.2616 | 0.2561 |
Toxoplasma gondii | cathepsin B | 0.1368 | 0.2894 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1278 | 0.2616 | 0.2127 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Brugia malayi | Cathepsin L-like precursor | 0.1278 | 0.2616 | 0.2561 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0757 | 0.1008 | 0.3676 |
Loa Loa (eye worm) | fibroinase | 0.1278 | 0.2616 | 0.2561 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1278 | 0.2616 | 0.2561 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0952 | 0.1608 | 0.1608 |
Plasmodium vivax | vivapain-2 | 0.1278 | 0.2616 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1278 | 0.2616 | 0.2127 |
Echinococcus granulosus | calpain A | 0.1832 | 0.4326 | 0.395 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0858 | 0.132 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.132 | 0.1255 |
Brugia malayi | Cathepsin L-like precursor | 0.1278 | 0.2616 | 0.2561 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1278 | 0.2616 | 0.2557 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.1368 | 0.2894 | 0.9965 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0757 | 0.1008 | 0.0941 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.0622 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.1936 |
Echinococcus multilocularis | cysteine protease | 0.1278 | 0.2616 | 0.2127 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.1705 | 0.3934 | 0.3886 |
Brugia malayi | calpain 7 | 0.0632 | 0.0622 | 0.0552 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Echinococcus multilocularis | calpain A | 0.1832 | 0.4326 | 0.395 |
Echinococcus granulosus | cysteine protease | 0.0757 | 0.1008 | 0.0412 |
Trypanosoma cruzi | cysteine protease, putative | 0.0757 | 0.1008 | 0.1008 |
Brugia malayi | cathepsin L-like precursor | 0.0858 | 0.132 | 0.1255 |
Echinococcus granulosus | cathepsin b | 0.3671 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1372 | 0.2904 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0632 | 0.0622 | 0.0622 |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Trypanosoma brucei | calpain-like protein, putative | 0.0632 | 0.0622 | 0.1936 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.1368 | 0.2894 | 1 |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0757 | 0.1008 | 0.3676 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1278 | 0.2616 | 0.2127 |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Plasmodium vivax | unspecified product | 0.0757 | 0.1008 | 0.1938 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1368 | 0.2894 | 0.2837 |
Brugia malayi | Cathepsin L-like precursor | 0.1278 | 0.2616 | 0.2561 |
Giardia lamblia | Cathepsin B precursor | 0.1368 | 0.2894 | 0.5 |
Loa Loa (eye worm) | calpain family protein 1 | 0.1251 | 0.2531 | 0.2476 |
Brugia malayi | Cathepsin L-like precursor | 0.1278 | 0.2616 | 0.2561 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.2511 | 0.6422 | 0.6393 |
Trypanosoma cruzi | kinesin, putative | 0.0455 | 0.0074 | 0.0074 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1278 | 0.2616 | 0.2127 |
Echinococcus multilocularis | calpain family protein 1, d | 0.1251 | 0.2531 | 0.2036 |
Loa Loa (eye worm) | hypothetical protein | 0.1528 | 0.3386 | 0.3337 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.183 | 0.4319 | 0.4274 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.3671 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0858 | 0.132 | 0.1653 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.132 | 0.1255 |
Echinococcus multilocularis | cathepsin b | 0.3671 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0757 | 0.1008 | 0.3676 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 0.3934 | 0.3889 |
Plasmodium vivax | vivapain-2 | 0.1278 | 0.2616 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1278 | 0.2616 | 1 |
Schistosoma mansoni | calpain (C02 family) | 0.0632 | 0.0622 | 0.0546 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0757 | 0.1008 | 0.0936 |
Giardia lamblia | Cathepsin B precursor | 0.1368 | 0.2894 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1073 | 0.1983 | 0.1924 |
Leishmania major | cathepsin L-like protease | 0.1372 | 0.2904 | 1 |
Plasmodium vivax | vivapain-3 | 0.0757 | 0.1008 | 0.1938 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0757 | 0.1008 | 0.0936 |
Leishmania major | cathepsin L-like protease | 0.1278 | 0.2616 | 0.8983 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.183 | 0.4319 | 0.3943 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.3671 | 1 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0632 | 0.0622 | 0.0622 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.1278 | 0.2616 | 0.2561 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1278 | 0.2616 | 0.2127 |
Echinococcus multilocularis | cathepsin b | 0.3671 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0858 | 0.132 | 0.125 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0632 | 0.0622 | 0.1936 |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Brugia malayi | Cathepsin L-like precursor | 0.1278 | 0.2616 | 0.2561 |
Onchocerca volvulus | 0.1278 | 0.2616 | 1 | |
Entamoeba histolytica | cysteine proteinase 2 | 0.0757 | 0.1008 | 0.3676 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Schistosoma mansoni | calpain C (C02 family) | 0.0632 | 0.0622 | 0.0546 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0757 | 0.1008 | 0.3302 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0757 | 0.1008 | 0.0412 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1251 | 0.2531 | 0.2476 |
Trypanosoma brucei | calpain-like protein, putative | 0.0632 | 0.0622 | 0.1936 |
Onchocerca volvulus | Cathepsin F homolog | 0.1278 | 0.2616 | 1 |
Leishmania major | calpain, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.1936 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.1368 | 0.2894 | 0.9965 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Leishmania major | cathepsin L-like protease | 0.1278 | 0.2616 | 0.8983 |
Brugia malayi | calpain family protein 1 | 0.1705 | 0.3934 | 0.3889 |
Trypanosoma brucei | antigen, putative | 0.0632 | 0.0622 | 0.1936 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0757 | 0.1008 | 0.1008 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0757 | 0.1008 | 0.1008 |
Onchocerca volvulus | Cathepsin L homolog | 0.1278 | 0.2616 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Loa Loa (eye worm) | cathepsin B | 0.1368 | 0.2894 | 0.2841 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1278 | 0.2616 | 0.2561 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Echinococcus granulosus | cathepsin L | 0.0757 | 0.1008 | 0.0412 |
Onchocerca volvulus | 0.1073 | 0.1983 | 0.5117 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Loa Loa (eye worm) | hypothetical protein | 0.1278 | 0.2616 | 0.2561 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1278 | 0.2616 | 0.2127 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0632 | 0.0622 | 0.0622 |
Trypanosoma cruzi | kinesin, putative | 0.0455 | 0.0074 | 0.0074 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.0622 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Leishmania major | cathepsin L-like protease | 0.1372 | 0.2904 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.1936 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1372 | 0.2904 | 0.2904 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1278 | 0.2616 | 1 |
Leishmania major | cathepsin L-like protease | 0.1278 | 0.2616 | 0.8983 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.0632 | 0.0622 | 0.0546 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0757 | 0.1008 | 0.3302 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1372 | 0.2904 | 0.2904 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1278 | 0.2616 | 0.2557 |
Leishmania major | cathepsin L-like protease | 0.1278 | 0.2616 | 0.8983 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1278 | 0.2616 | 0.2127 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Entamoeba histolytica | cysteine protease, putative | 0.1278 | 0.2616 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1372 | 0.2904 | 0.2904 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1278 | 0.2616 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1372 | 0.2904 | 0.2904 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.183 | 0.4319 | 0.3943 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Brugia malayi | Cathepsin L-like precursor | 0.0858 | 0.132 | 0.1255 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1278 | 0.2616 | 1 |
Plasmodium vivax | vivapain-1 | 0.0757 | 0.1008 | 0.1938 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1372 | 0.2904 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1278 | 0.2616 | 0.2561 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0632 | 0.0622 | 0.0622 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Brugia malayi | calpain family protein 1 | 0.1705 | 0.3934 | 0.3889 |
Trypanosoma brucei | calpain-like protein, putative | 0.0632 | 0.0622 | 0.1936 |
Leishmania major | cathepsin L-like protease | 0.1278 | 0.2616 | 0.8983 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0632 | 0.0622 | 0.1936 |
Trypanosoma brucei | calpain-like protein, putative | 0.0632 | 0.0622 | 0.1936 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0757 | 0.1008 | 0.3676 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0757 | 0.1008 | 0.3676 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1278 | 0.2616 | 0.8526 |
Entamoeba histolytica | cysteine protease, putative | 0.0757 | 0.1008 | 0.3676 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED30 (functional) | = 20 ug kg-1 | Beta agonistic activity as the dose required to increase heart rate by 30 beats/min in anesthetized rats upon intravenous administration | ChEMBL. | 6138435 |
ED30 (functional) | = 20 ug kg-1 | Beta agonistic activity as the dose required to increase heart rate by 30 beats/min in anesthetized rats upon intravenous administration | ChEMBL. | 6138435 |
ED50 (functional) | = 15 ug kg-1 | Beta-1 adrenoceptor blocking activity as the dose required to inhibit 50% of tachycardia in anesthetized rats | ChEMBL. | 6138435 |
ED50 (functional) | = 15 ug kg-1 | Beta-1 adrenoceptor blocking activity as the dose required to inhibit 50% of tachycardia in anesthetized rats | ChEMBL. | 6138435 |
ED50 (functional) | > 50000 ug kg-1 | Beta-2 adrenergic receptor antagonist activity as the dose required to inhibit 50% of vasodepressor response in anesthetized rats | ChEMBL. | 6138435 |
ED50 (functional) | > 50000 ug kg-1 | Beta-2 adrenergic receptor antagonist activity as the dose required to inhibit 50% of vasodepressor response in anesthetized rats | ChEMBL. | 6138435 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.