Detailed information for compound 574735

Basic information

Technical information
  • TDR Targets ID: 574735
  • Name: 2H-benzotriazole-4-carboxylic acid
  • MW: 163.133 | Formula: C7H5N3O2
  • H donors: 2 H acceptors: 4 LogP: 0.55 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cccc2c1n[nH]n2
  • InChi: 1S/C7H5N3O2/c11-7(12)4-2-1-3-5-6(4)9-10-8-5/h1-3H,(H,11,12)(H,8,9,10)
  • InChiKey: KFJDQPJLANOOOB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1H-benzotriazole-7-carboxylic acid
  • 62972-61-6
  • Benzotriazole-7-cooh
  • 1H-Benzotriazole-4-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major diacylglycerol kinase, putative 0.005 0.0073 0.5
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.005 0.0073 0.5
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.005 0.0073 0.5
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.005 0.0073 0.0073
Plasmodium vivax diacylglycerol kinase, putative 0.005 0.0073 0.5
Leishmania major hypothetical protein, conserved 0.005 0.0073 0.5
Loa Loa (eye worm) diacylglycerol kinase 2 0.005 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.0073
Echinococcus multilocularis sphingosine kinase 1 0.1275 1 1
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.005 0.0073 0.5
Loa Loa (eye worm) hypothetical protein 0.1275 1 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0073 0.5
Schistosoma mansoni hypothetical protein 0.005 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.005 0.0079 0.0079
Trypanosoma cruzi Sphingosine kinase 0.005 0.0073 0.5
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.005 0.0073 0.5
Loa Loa (eye worm) ceramide kinase 0.005 0.0073 0.0073
Echinococcus multilocularis metabotropic glutamate receptor 5 0.005 0.0079 0.0006
Trypanosoma brucei Sphingosine kinase 0.005 0.0073 0.5
Leishmania major diacylglycerol kinase-like protein 0.005 0.0073 0.5
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.005 0.0073 0.5
Trichomonas vaginalis diacylglycerol kinase, putative 0.005 0.0073 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.0073
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.005 0.0073 0.5
Entamoeba histolytica hypothetical protein, conserved 0.1275 1 1
Onchocerca volvulus Ceramide kinase 1 homolog 0.005 0.0073 0.5
Trypanosoma cruzi diacylglycerol kinase, putative 0.005 0.0073 0.5
Trichomonas vaginalis bmru protein, putative 0.005 0.0073 0.5
Toxoplasma gondii diacylglycerol kinase, putative 0.005 0.0073 0.5
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.005 0.0073 0.5
Leishmania major sphingosine kinase A, B, putative 0.005 0.0073 0.5
Schistosoma mansoni sphingosine kinase A B 0.1275 1 1
Schistosoma mansoni diacylglycerol kinase theta 0.005 0.0073 0.0073
Trichomonas vaginalis sphingosine kinase, putative 0.005 0.0073 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0073 0.5
Schistosoma mansoni sphingoid long chain base kinase 0.1275 1 1
Plasmodium falciparum diacylglycerol kinase, putative 0.005 0.0073 0.5
Brugia malayi metabotropic glutamate receptor type 2 0.005 0.0079 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.0073
Mycobacterium ulcerans hypothetical protein 0.1275 1 1
Leishmania major hypothetical protein, conserved 0.005 0.0073 0.5
Plasmodium vivax diacylglycerol kinase, putative 0.005 0.0073 0.5
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.005 0.0073 0.5
Schistosoma mansoni metabotropic glutamate receptor 0.005 0.0079 0.0079
Trichomonas vaginalis diacylglycerol kinase, putative 0.005 0.0073 0.5
Schistosoma mansoni diacylglycerol kinase zeta iota 0.005 0.0073 0.0073
Trypanosoma brucei diacylglycerol kinase, putative 0.005 0.0073 0.5
Plasmodium falciparum diacylglycerol kinase, putative 0.005 0.0073 0.5
Mycobacterium tuberculosis Conserved protein 0.1275 1 1
Trichomonas vaginalis bmru protein, putative 0.005 0.0073 0.5
Echinococcus granulosus metabotropic glutamate receptor 5 0.005 0.0079 0.0006
Trypanosoma cruzi Sphingosine kinase 0.005 0.0073 0.5
Trypanosoma cruzi diacylglycerol kinase, putative 0.005 0.0073 0.5
Schistosoma mansoni diacylglycerol kinase theta 0.005 0.0073 0.0073
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0073 0.5
Trichomonas vaginalis sphingosine kinase, putative 0.005 0.0073 0.5
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.005 0.0073 0.5
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.005 0.0073 0.0073
Onchocerca volvulus 0.005 0.0073 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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