TDR Targets

Basic information

Technical information

TDR Targets ID: 574753
Name: N-[amino-[N'-[(4-bromophenyl)methylene]hydraz ino]methyl]nitramide
MW: 288.101 | Formula: C8H10BrN5O2
H donors: 3 H acceptors: 2 LogP: 2.27 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: NC(N[N+](=O)[O-])NN=Cc1ccc(cc1)Br
InChi: 1S/C8H10BrN5O2/c9-7-3-1-6(2-4-7)5-11-12-8(10)13-14(15)16/h1-5,8,12-13H,10H2
InChiKey: UFYIYLFFYMASFN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[azanyl-[2-[(4-bromophenyl)methylidene]hydrazinyl]methyl]nitramide
N-[amino-[N'-(4-bromobenzylidene)hydrazino]methyl]nitramide
N-[amino-[2-[(4-bromophenyl)methylidene]hydrazinyl]methyl]nitramide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	troponin I	0.0113	0.517	0.796
Schistosoma mansoni	troponin I	0.0113	0.517	0.796
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0149	0.0546
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0007	0.0149	0.0328
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0943	0.0806
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0149	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0017	0.061	0.0467
Echinococcus granulosus	troponin i	0.0113	0.517	0.6165
Onchocerca volvulus		0.0024	0.0943	0.1259
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0659	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.4552	1
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.4552	1
Echinococcus multilocularis	troponin i	0.0113	0.517	0.6165
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0613	0.6071
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.01	0.4552	0.5406
Schistosoma mansoni	kinase	0.0051	0.2225	0.329
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0659	1
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.4552	1
Schistosoma mansoni	hypothetical protein	0.0113	0.517	0.796
Entamoeba histolytica	serine/threonine protein kinase, putative	0.01	0.4552	1
Loa Loa (eye worm)	troponin	0.0067	0.2993	0.2887
Trypanosoma cruzi	polo-like protein kinase, putative	0.01	0.4552	1
Giardia lamblia	Kinase, PLK	0.01	0.4552	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0943	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.517	0.5096
Schistosoma mansoni	troponin I	0.0113	0.517	0.796
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0007	0.0149	0.5
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0943	1
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0149	0.0546
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.061	0.0467
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0179	0.8293	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0613	0.6071
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0943	0.2072
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0943	1
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0149	0.0546
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.2317	0.22
Schistosoma mansoni	troponin I	0.0113	0.517	0.796
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0943	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.061	0.0565
Schistosoma mansoni	hypothetical protein	0.0017	0.061	0.073
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0659	0.0518
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.4552	1
Schistosoma mansoni	hypothetical protein	0.0017	0.061	0.073
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0149	0.0546
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0149	0.0546
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0943	1
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.01	0.4552	0.5406
Brugia malayi	Troponin T	0.0067	0.2993	0.2887
Schistosoma mansoni	hypothetical protein	0.0017	0.061	0.073
Loa Loa (eye worm)	hypothetical protein	0.0067	0.2993	0.2887
Brugia malayi	Troponin family protein	0.0113	0.517	0.5096
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0943	0.1803
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0659	0.0518
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0943	0.0806
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0943	0.0806
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0149	0.0328
Toxoplasma gondii	propionate-CoA ligase	0.0007	0.0149	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.4552	0.698
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.2317	0.22
Loa Loa (eye worm)	troponin I	0.0113	0.517	0.5096
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0943	0.2072
Echinococcus granulosus	oncosphere protein Tso22e	0.014	0.6456	0.7745
Onchocerca volvulus	Troponin T, skeletal muscle homolog	0.0067	0.2993	0.4509
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.4552	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0659	0.6421
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0149	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0659	0.0518
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0943	0.1803
Echinococcus multilocularis	oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22	0.014	0.6456	0.7745
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0149	0.0328
Echinococcus granulosus	GPCR family 2	0.0017	0.061	0.0565
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.4552	1
Brugia malayi	Troponin T	0.0067	0.2993	0.2887
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0943	0.1803
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0943	0.0806
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0149	0.0328
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0943	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0613	0.6071
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0943	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.01	0.4552	0.4469
Schistosoma mansoni	hypothetical protein	0.0017	0.061	0.073
Trypanosoma cruzi	polo-like protein kinase, putative	0.01	0.4552	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0943	0.2072
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0179	0.8293	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0943	1
Schistosoma mansoni	troponin t invertebrate	0.014	0.6456	1
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0149	0.0328
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0943	1
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0149	0.0328
Onchocerca volvulus	Troponin I homolog	0.0113	0.517	0.796
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0943	1
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0149	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1527	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0943	0.0806
Trypanosoma brucei	polo-like protein kinase	0.01	0.4552	1
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.2162	0.4572
Loa Loa (eye worm)	hypothetical protein	0.0215	1	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0943	1
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0149	0.0328
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0007	0.0149	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.2162	0.4572
Echinococcus multilocularis	GPCR, family 2	0.0017	0.061	0.0565
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0149	0.0546
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.1527	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0659	0.0518
Schistosoma mansoni	hypothetical protein	0.0036	0.1527	0.2184
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.01	0.4552	0.4469
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0943	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0943	0.0806
Onchocerca volvulus	Troponin T, skeletal muscle homolog	0.014	0.6456	1
Brugia malayi	Troponin I	0.0113	0.517	0.5096
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0007	0.0149	0.2265
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.4552	1
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.061	0.0467
Loa Loa (eye worm)	troponin T	0.0067	0.2993	0.2887
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0659	0.6617
Onchocerca volvulus	Serine\/threonine kinase homolog	0.01	0.4552	0.698
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0149	0.0546
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0659	1
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0149	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0659	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0113	0.517	0.5096
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0149	0.0546
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.061	0.0565
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0613	0.6071
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.01	0.4552	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0149	0.0546
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.061	0.0467
Brugia malayi	Troponin T	0.0067	0.2993	0.2887
Brugia malayi	hypothetical protein	0.0067	0.2993	0.2887

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 24193747

Bibliographic References

No literature references available for this target.

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Detailed information for compound 574753