Detailed information for compound 574992

Basic information

Technical information
  • TDR Targets ID: 574992
  • Name: 3-[N'-(2-oxo-1-naphthylidene)hydrazino]benzen esulfonate
  • MW: 327.335 | Formula: C16H11N2O4S-
  • H donors: 1 H acceptors: 4 LogP: 2.31 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C=Cc2c(C1=NNc1cccc(c1)S(=O)(=O)[O-])cccc2
  • InChi: 1S/C16H12N2O4S/c19-15-9-8-11-4-1-2-7-14(11)16(15)18-17-12-5-3-6-13(10-12)23(20,21)22/h1-10,17H,(H,20,21,22)/p-1
  • InChiKey: MEVGLBAVTZFMIV-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-(2-oxonaphthalen-1-ylidene)hydrazinyl]benzenesulfonate
  • 3-[N'-(2-keto-1-naphthylidene)hydrazino]besylate
  • 2-naphthol orange

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0644 0.1485
Brugia malayi Sugar transporter family protein 0.0103 0.2206 0.626
Schistosoma mansoni glucose transport protein 0.0103 0.2206 0.626
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0525 0.1489
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.054 0.2446
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0525 1
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0549 0.1973
Schistosoma mansoni sugar transporter 0.0015 0.0142 0.0402
Loa Loa (eye worm) sugar transporter 0.0103 0.2206 1
Onchocerca volvulus 0.0015 0.0142 0.3451
Echinococcus granulosus peroxidasin 0.0026 0.0411 0.1862
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0411 0.1862
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.3686 0.3595
Brugia malayi Sugar transporter family protein 0.0015 0.0142 0.0402
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0062 0.1257 0.5401
Echinococcus multilocularis General substrate transporter 0.0089 0.1869 0.8469
Trypanosoma brucei glucose transporter, putative 0.0032 0.0549 0.1204
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0494 0.2239
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0142 0.0402
Trypanosoma brucei glucose transporter 1E 0.0032 0.0549 0.1204
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0411 0.1165
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0059 0.5
Brugia malayi hypothetical protein 0.0015 0.0142 0.0402
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.054 0.2446
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.016 0.3525 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Toxoplasma gondii protein kinase, putative 0.0292 0.6591 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0549 0.1973
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2206 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.034 0.0813
Brugia malayi Peroxidasin 0.0026 0.0411 0.1165
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0142 0.0215
Trypanosoma brucei glucose transporter 2A 0.0032 0.0549 0.1204
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0411 1
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.016 0.3525 0.3431
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0142 0.0402
Onchocerca volvulus 0.0015 0.0142 0.3451
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0525 0.0813
Onchocerca volvulus Peroxidase homolog 0.0026 0.0411 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0549 0.1204
Echinococcus multilocularis solute carrier family 22 0.0015 0.0142 0.0643
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0411 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2206 1
Leishmania major dihydroorotate dehydrogenase 0.016 0.3525 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.034 0.0248
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2206 1
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0549 0.1973
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.3686 0.5592
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.054 0.2446
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.034 0.0587
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.034 0.0516
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.054 0.0404
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0644 0.051
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.034 1
Onchocerca volvulus Peroxidase homolog 0.0026 0.0411 1
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.034 0.0587
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0411 0.1165
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0062 0.1257 0.5401
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0062 0.1257 0.5696
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.034 0.0813
Schistosoma mansoni peroxidasin 0.0026 0.0411 0.1165
Onchocerca volvulus 0.0015 0.0142 0.3451
Loa Loa (eye worm) hypothetical protein 0.0031 0.0525 0.2378
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.054 0.2446
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.054 0.0404
Trypanosoma brucei glucose transporter, putative 0.0032 0.0549 0.1204
Brugia malayi hypothetical protein 0.0026 0.0411 0.1165
Leishmania major protein kinase, putative 0.0032 0.054 0.1176
Trypanosoma brucei glucose transporter, putative 0.0032 0.0549 0.1204
Trypanosoma brucei glucose transporter, putative 0.0032 0.0549 0.1204
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.054 0.0404
Onchocerca volvulus 0.0015 0.0142 0.3451
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.2206 0.3347
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0494 0.2239
Onchocerca volvulus 0.0015 0.0142 0.3451
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.2206 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0549 0.1973
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.034 0.6484
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.034 0.0201
Brugia malayi Blistered cuticle protein 3 0.0026 0.0411 0.1165
Entamoeba histolytica protein kinase, putative 0.0032 0.054 0.2175
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Echinococcus granulosus solute carrier family 22 0.0015 0.0142 0.0643
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.3686 0.3595
Onchocerca volvulus 0.0015 0.0142 0.3451
Onchocerca volvulus 0.0026 0.0411 1
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0411 0.1862
Echinococcus multilocularis solute carrier family 22 0.0015 0.0142 0.0643
Brugia malayi major facilitator superfamily protein 0.0015 0.0142 0.0402
Onchocerca volvulus 0.0015 0.0142 0.3451
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Brugia malayi lysyl-tRNA synthetase 0.0023 0.034 0.0965
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.016 0.3525 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.054 0.2446
Loa Loa (eye worm) hypothetical protein 0.0032 0.054 0.2446
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0142 0.0402
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0644 0.0977
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Entamoeba histolytica protein kinase, putative 0.0032 0.054 0.2175
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2206 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0644 0.1485
Brugia malayi Sugar transporter family protein 0.0015 0.0142 0.0402
Onchocerca volvulus 0.0015 0.0142 0.3451
Echinococcus multilocularis solute carrier family 22 0.0015 0.0142 0.0643
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2206 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0439 1 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0411 0.1165
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.016 0.3525 1
Echinococcus granulosus solute carrier family 22 0.0015 0.0142 0.0643
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Brugia malayi Cam kinase protein 1 0.0032 0.054 0.1531
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0525 0.2013
Brugia malayi hypothetical protein 0.0015 0.0142 0.0402
Giardia lamblia Hexose transporter 0.0015 0.0142 0.2702
Onchocerca volvulus 0.0015 0.0142 0.3451
Toxoplasma gondii sugar transporter ST1 0.0015 0.0142 0.0215
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0142 0.0643
Schistosoma mansoni dihydroorotate dehydrogenase 0.016 0.3525 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.054 0.2446
Leishmania major glucose transporter, lmgt2 0.0032 0.0549 0.1204
Leishmania major glucose transporter, lmgt1 0.0032 0.0549 0.1204
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0549 0.1973
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.054 0.0819
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.054 0.0819
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2206 1
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.054 0.1927
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2206 1
Onchocerca volvulus 0.0015 0.0142 0.3451
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.034 0.0965
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0142 0.0643
Plasmodium falciparum hexose transporter 0.0103 0.2206 0.2094
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.054 0.1531
Trypanosoma brucei glucose transporter, putative 0.0032 0.0549 0.1204
Trypanosoma brucei glucose transporter, putative 0.0032 0.0549 0.1204
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.016 0.3525 1
Schistosoma mansoni hypothetical protein 0.0103 0.2206 0.626
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.054 0.0404
Brugia malayi Zinc finger, C2H2 type family protein 0.0062 0.1257 0.3566
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0411 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.054 0.0819
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.054 0.1176
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.034 0.0965
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0142 0.0643
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0411 0.1165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0062 0.1257 0.5696
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.016 0.3525 0.5347
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0549 0.1204
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0142 0.0402
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.054 0.1531
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.016 0.3525 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0549 0.1973
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.054 0.2446
Onchocerca volvulus 0.0015 0.0142 0.3451
Onchocerca volvulus 0.0026 0.0411 1
Onchocerca volvulus 0.0015 0.0142 0.3451
Schistosoma mansoni sugar transporter 0.0015 0.0142 0.0402
Onchocerca volvulus 0.0026 0.0411 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0549 0.1204
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.016 0.3525 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.034 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0549 0.1973
Giardia lamblia Sugar-proton symporter 0.0015 0.0142 0.2702
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0525 0.1489
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0644 0.1485
Leishmania major glucose transporter, lmgt3 0.0032 0.0549 0.1204
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0411 1
Echinococcus granulosus solute carrier family 22 0.0015 0.0142 0.0643
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0549 0.1204
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.054 0.2446
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.016 0.3525 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.034 0.1542
Toxoplasma gondii sugar transporter ST3 0.0015 0.0142 0.0215
Schistosoma mansoni glucose transport protein 0.0103 0.2206 0.626
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Onchocerca volvulus 0.0015 0.0142 0.3451
Mycobacterium ulcerans sugar transporter 0.0015 0.0142 0.024
Plasmodium falciparum dihydroorotate dehydrogenase 0.016 0.3525 0.3431
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.016 0.3525 1
Schistosoma mansoni protein kinase 0.0032 0.054 0.1531
Echinococcus granulosus General substrate transporter 0.0089 0.1869 0.8469
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0142 0.024
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.034 0.0961
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.2206 1
Brugia malayi hypothetical protein 0.0015 0.0142 0.0402
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0142 0.0643
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0062 0.1257 0.5401
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.016 0.3525 1
Plasmodium falciparum protein kinase 7 0.0292 0.6591 0.6542
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0062 0.1257 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0644 0.1485
Schistosoma mansoni protein kinase 0.0032 0.054 0.1531
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0142 0.024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Schistosoma mansoni sugar transporter 0.0015 0.0142 0.0402
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0062 0.1257 0.5696
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Onchocerca volvulus 0.0015 0.0142 0.3451
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0259 0.0348
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.054 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0549 0.1204
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.034 0.1542
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0259 0.0348
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Onchocerca volvulus Putative transporter 0.0015 0.0142 0.3451
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0411 0.1862
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.054 0.0404
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.016 0.3525 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.054 0.2446
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0411 0.1862
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.054 0.0404
Loa Loa (eye worm) hypothetical protein 0.0025 0.039 0.1766
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0549 0.1204
Trypanosoma cruzi hexose transporter 0.0032 0.0549 0.1204
Loa Loa (eye worm) hypothetical protein 0.0031 0.0525 0.2378
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0549 0.1204
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0525 0.2378
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Onchocerca volvulus 0.0015 0.0142 0.3451
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0549 0.1204
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0644 0.1485
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Schistosoma mansoni peroxidasin 0.0026 0.0411 0.1165
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.01 0.0452
Echinococcus multilocularis solute carrier family 22 0.0015 0.0142 0.0643
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0525 0.1489
Schistosoma mansoni glucose transporter 0.0015 0.0142 0.0402
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0411 0.1165
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0142 0.0643
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0062 0.1257 0.5401
Loa Loa (eye worm) hypothetical protein 0.0015 0.0142 0.0643
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0142 0.0643
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0142 0.024
Echinococcus multilocularis peroxidasin 0.0026 0.0411 0.1862
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0411 0.1862
Onchocerca volvulus 0.0015 0.0142 0.3451
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.054 0.2446
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.1862
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0525 0.1489
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0062 0.1257 0.5401
Plasmodium vivax hexose transporter 0.0103 0.2206 0.2094
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0062 0.1257 0.5401
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.034 0.1542
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0062 0.1257 0.3296
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.054 0.0404
Echinococcus granulosus solute carrier family 22 0.0015 0.0142 0.0643
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.034 0.0201
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0211 0.0205
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0062 0.1257 0.5696
Trypanosoma brucei glucose transporter, putative 0.0032 0.0549 0.1204
Schistosoma mansoni sugar transporter 0.0015 0.0142 0.0402
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.054 0.0404
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0644 0.051
Schistosoma mansoni protein kinase 0.0032 0.054 0.1531
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0274 0.0641
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0525 0.2378
Toxoplasma gondii sugar transporter ST2 0.0015 0.0142 0.0215
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0525 0.1855
Loa Loa (eye worm) sugar transporter 0.0015 0.0142 0.0643
Schistosoma mansoni glucose transport protein 0.0103 0.2206 0.626
Brugia malayi major facilitator superfamily protein 0.0015 0.0142 0.0402

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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