Detailed information for compound 579534

Basic information

Technical information
  • TDR Targets ID: 579534
  • Name: ethane-1,1,2,2-tetrol; platinum; dihydrate
  • MW: 325.175 | Formula: C2H10O6Pt
  • H donors: 6 H acceptors: 6 LogP: -3.13 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(C(O)O)O.[Pt].O.O
  • InChi: 1S/C2H6O4.2H2O.Pt/c3-1(4)2(5)6;;;/h1-6H;2*1H2;
  • InChiKey: RYOPHBHJTVCSKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7240-17-7

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum glutathione reductase 0.0096 0.1847 1
Brugia malayi Transient-receptor-potential like protein 0.0043 0.0655 0.1104
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0472 0.0356
Brugia malayi Pre-SET motif family protein 0.0034 0.0472 0.0726
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0517 0.0401
Brugia malayi jmjC domain containing protein 0.0113 0.2218 0.4334
Brugia malayi PHD-finger family protein 0.0034 0.0472 0.0726
Schistosoma mansoni cpg binding protein 0.0034 0.0469 0.0353
Echinococcus multilocularis cpg binding protein 0.0034 0.0469 0.0353
Echinococcus granulosus thioredoxin glutathione reductase 0.0097 0.186 0.176
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0448 0.1892
Echinococcus granulosus cpg binding protein 0.0034 0.0469 0.0353
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.0634 0.0519
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0675 0.0561
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0448 0.1892
Echinococcus granulosus jumonji domain containing protein 0.0048 0.0773 0.066
Schistosoma mansoni hypothetical protein 0.0034 0.0472 0.0356
Echinococcus granulosus short transient receptor potential channel 6 0.0076 0.1394 0.1289
Loa Loa (eye worm) hypothetical protein 0.0058 0.0994 0.1805
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1102 0.5684
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0244 0.5137 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0448 0.1892
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0448 0.1892
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0448 0.1892
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0448 0.0331
Echinococcus multilocularis dnaJ subfamily B 0.0462 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0429 0.0312
Loa Loa (eye worm) hypothetical protein 0.0072 0.1309 0.2456
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.1847 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.2272 0.4445
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.2272 0.4445
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0448 0.1892
Echinococcus multilocularis jumonji domain containing protein 0.0048 0.0773 0.066
Toxoplasma gondii thioredoxin reductase 0.0096 0.1847 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0994 0.1805
Echinococcus granulosus transient receptor potential gamma protein 0.0115 0.2259 0.2164
Plasmodium falciparum glutathione reductase 0.0033 0.0448 0.2423
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0163 0.0043
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.1847 0.3442
Loa Loa (eye worm) glutathione reductase 0.0096 0.1847 0.3568
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0675 0.0561
Schistosoma mansoni transient receptor potential channel 0.0115 0.2259 0.2164
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0113 0.2218 0.2122
Brugia malayi Pre-SET motif family protein 0.0236 0.4959 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0448 0.1892
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.025 0.0268
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.016 0.3273 0.6514
Loa Loa (eye worm) hypothetical protein 0.0115 0.2259 0.4419
Loa Loa (eye worm) hypothetical protein 0.0036 0.0517 0.0819
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0448 0.1892
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0448 0.1892
Schistosoma mansoni hypothetical protein 0.0079 0.146 0.1355
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0517 0.0401
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0448 0.1892
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0472 0.0356
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.2272 0.4445
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0448 0.0675
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0448 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0.146 0.2767
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0472 0.0726
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.4959 1
Giardia lamblia PHD finger protein 15 0.0034 0.0472 1
Echinococcus granulosus peregrin 0.0034 0.0472 0.0356
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0448 0.0331
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0219 0.4592 0.8913
Schistosoma mansoni cpg binding protein 0.0032 0.0428 0.0311
Loa Loa (eye worm) hypothetical protein 0.0059 0.102 0.1859
Onchocerca volvulus 0.0268 0.5683 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.025 0.0268
Schistosoma mansoni hypothetical protein 0.0462 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0244 0.5137 1
Schistosoma mansoni cpg binding protein 0.0034 0.0469 0.0353
Treponema pallidum NADH oxidase 0.0033 0.0448 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0517 0.0401
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0121 0.0655
Echinococcus granulosus transient receptor potential ion channel A 0.0111 0.2174 0.2078
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.1289 0.2415
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0448 0.5
Leishmania major trypanothione reductase 0.0096 0.1847 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.2272 0.4445
Brugia malayi Thioredoxin reductase 0.0096 0.1847 0.3568
Schistosoma mansoni hypothetical protein 0.0036 0.0517 0.0401
Trichomonas vaginalis set domain proteins, putative 0.0268 0.5683 1
Schistosoma mansoni hypothetical protein 0.0036 0.0517 0.0401
Trypanosoma brucei trypanothione reductase 0.0096 0.1847 1
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.1847 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0244 0.5137 1
Toxoplasma gondii hypothetical protein 0.0058 0.0994 0.5058
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0472 0.0356
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0043 0.0655 0.0541
Echinococcus granulosus short transient receptor potential channel 6 0.0076 0.1394 0.1289
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0448 0.2423
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0448 0.1892
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0472 0.2557
Mycobacterium tuberculosis Probable dehydrogenase 0.0219 0.4592 0.8913
Echinococcus multilocularis peregrin 0.0034 0.0472 0.0356
Schistosoma mansoni hypothetical protein 0.0036 0.0517 0.0401
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0517 0.0819
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.1266 0.1159
Plasmodium vivax SET domain protein, putative 0.0034 0.0472 0.2557
Echinococcus multilocularis transient receptor potential ion channel A 0.0111 0.2174 0.2078
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0448 0.1892
Onchocerca volvulus Alhambra homolog 0.0034 0.0472 0.0084
Schistosoma mansoni transient receptor potential channel 4 0.0115 0.2259 0.2164
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0219 0.4592 0.8913
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0472 0.0356
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0448 0.1892
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0219 0.4592 0.8913
Plasmodium falciparum thioredoxin reductase 0.0096 0.1847 1
Onchocerca volvulus 0.0034 0.0472 0.0084
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0204 0.0172
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0517 0.0401
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0472 0.2035
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0448 0.1892
Plasmodium vivax glutathione reductase, putative 0.0096 0.1847 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0472 0.0356
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0472 0.0356
Plasmodium falciparum thioredoxin reductase 0.0033 0.0448 0.2423
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0428 0.0635
Loa Loa (eye worm) hypothetical protein 0.0039 0.057 0.0928
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0448 0.5
Echinococcus multilocularis transient receptor potential gamma protein 0.0115 0.2259 0.2164
Echinococcus multilocularis short transient receptor potential channel 6 0.0076 0.1394 0.1289
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0517 0.0819
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0472 0.2035
Plasmodium falciparum phd finger protein, putative 0.0034 0.0472 0.2557
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0448 0.0331
Brugia malayi Bromodomain containing protein 0.0034 0.0472 0.0726
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0219 0.4592 0.8913
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0448 0.1892
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0448 0.2423
Echinococcus multilocularis GPCR, family 2 0.0036 0.0517 0.0401
Brugia malayi CXXC zinc finger family protein 0.0032 0.0428 0.0635
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0472 0.0356
Schistosoma mansoni hypothetical protein 0.0036 0.0517 0.0401
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.1847 0.3568
Loa Loa (eye worm) hypothetical protein 0.0043 0.0655 0.1104
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0448 0.2423
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0472 0.0356
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0448 0.1892
Echinococcus granulosus GPCR family 2 0.0036 0.0517 0.0401
Echinococcus multilocularis thioredoxin glutathione reductase 0.0097 0.186 0.176
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0448 0.5
Schistosoma mansoni jumonji domain containing protein 0.009 0.1701 0.16
Brugia malayi jmjC domain containing protein 0.0044 0.0675 0.1145
Echinococcus multilocularis short transient receptor potential channel 6 0.0076 0.1394 0.1289
Mycobacterium tuberculosis Probable oxidoreductase 0.0244 0.5137 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0472 0.0726
Loa Loa (eye worm) hypothetical protein 0.0034 0.0472 0.0726
Loa Loa (eye worm) hypothetical protein 0.016 0.3273 0.6514
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0448 0.1892
Schistosoma mansoni transient receptor potential channel 0.0076 0.1394 0.1289
Mycobacterium tuberculosis Probable reductase 0.0219 0.4592 0.8913
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0448 0.2423
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.146 0.2767
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0472 0.2035
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0121 0.0655
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0113 0.2218 0.2122
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0472 0.0356
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0448 0.5
Schistosoma mansoni transient receptor potential channel 0.0076 0.1394 0.1289
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0675 0.1145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0448 0.1892
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0448 0.1892
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0675 0.0561
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0448 0.0651
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0472 0.0356
Echinococcus granulosus TRP transient receptor potential channel 0.0043 0.0655 0.0541
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0517 0.0819
Brugia malayi glutathione reductase 0.0096 0.1847 0.3568
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0448 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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