Detailed information for compound 581887

Basic information

Technical information
  • TDR Targets ID: 581887
  • Name: 1-phenylvinyl phosphate
  • MW: 198.113 | Formula: C8H7O4P--
  • H donors: 0 H acceptors: 3 LogP: 0.67 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=C(c1ccccc1)OP(=O)([O-])[O-]
  • InChi: 1S/C8H9O4P/c1-7(12-13(9,10)11)8-5-3-2-4-6-8/h2-6H,1H2,(H2,9,10,11)/p-2
  • InChiKey: AAGAISPOTYWQIV-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • 1-phenylethenyl phosphate
  • 76625-78-0
  • 1-Phenylvinyl phosphate, disodium salt
  • Benzenemethanol, alpha-methylene-, dihydrogen phosphate, disodium salt
  • alpha-Methylenebenzenemethanol dihydrogen phosphate, disodium salt

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0032 0.0035
Entamoeba histolytica hypothetical protein 0.0035 0.0264 0.0267
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0917 0.32
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0917 0.2613
Plasmodium falciparum carbonic anhydrase 0.0192 0.1722 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0917 0.2125
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0917 0.0917
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0917 0.2527
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0192 0.1722 0.4961
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0083 0.0107
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0032 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0032 0.0035
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0205 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0032 0.0074
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0379 0.345 0.9549
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0032 0.0074
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0032 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0264 0.0718
Schistosoma mansoni thyroid hormone receptor 0.001 0.0032 0.0074
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0192 0.1722 0.4961
Echinococcus multilocularis carbonic anhydrase 0.0192 0.1722 0.2379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0032 0.0032
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0192 0.1722 0.496
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0372 0.3386 0.3183
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0205 0.0205
Echinococcus granulosus carbonic anhydrase 0.0192 0.1722 0.4758
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0032 0.0035
Echinococcus granulosus dnaJ subfamily B 0.0396 0.3613 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0379 0.345 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0264 0.0359
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0917 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0917 0.07
Schistosoma mansoni hypothetical protein 0.0192 0.1722 0.4758
Mycobacterium ulcerans carbonic anhydrase 0.0269 0.243 0.2249
Brugia malayi nuclear receptor NHR-88 0.001 0.0032 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0032 0.0035
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0917 0.2613
Loa Loa (eye worm) hypothetical protein 0.0192 0.1722 0.496
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0032 0.0074
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0192 0.1722 0.4961
Schistosoma mansoni cpg binding protein 0.0029 0.0214 0.0578
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0021 0.0022
Schistosoma mansoni carbonic anhydrase 0.0192 0.1722 0.4758
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0032 0.0035
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0917 0.0917
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0917 0.0917
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0032 0.0074
Schistosoma mansoni hypothetical protein 0.0015 0.0083 0.0215
Echinococcus granulosus carbonic anhydrase 0.0192 0.1722 0.4758
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0192 0.1722 0.4961
Echinococcus granulosus GPCR family 2 0.0015 0.0083 0.0215
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0032 0.0074
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0032 0.0074
Entamoeba histolytica hypothetical protein 0.0035 0.0264 0.0267
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0015 0.0083 0.0215
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0917 0.2527
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0032 0.0074
Echinococcus granulosus carbonic anhydrase II 0.0379 0.345 0.9549
Loa Loa (eye worm) carbonic anhydrase 3 0.0379 0.345 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0032 0.0035
Schistosoma mansoni carbonic anhydrase 0.0269 0.243 0.6721
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0199 0.0519
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0083 0.0215
Loa Loa (eye worm) hypothetical protein 0.0033 0.0247 0.0659
Mycobacterium leprae Probable transmembrane transport protein 0.0229 0.2059 0.7547
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0379 0.345 0.9549
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0032 0.0032
Schistosoma mansoni nuclear hormone receptor 0.001 0.0032 0.0074
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0205 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0032 0.0035
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0379 0.345 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0083 0.018
Entamoeba histolytica carbonic anhydrase, putative 0.0269 0.243 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0032 0.0032
Schistosoma mansoni carbonic anhydrase-related 0.0192 0.1722 0.4758
Loa Loa (eye worm) hypothetical protein 0.0192 0.1722 0.496
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0032 0.0074
Echinococcus multilocularis geminin 0.0164 0.1462 0.2019
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0205 0.0205
Echinococcus multilocularis carbonic anhydrase 0.0192 0.1722 0.2379
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0032 0.0074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0032 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0032 0.0035
Schistosoma mansoni coup transcription factor 0.001 0.0032 0.0074
Leishmania major carbonic anhydrase-like protein 0.0379 0.345 1
Echinococcus granulosus cpg binding protein 0.0029 0.0214 0.0578
Schistosoma mansoni thyroid hormone receptor 0.001 0.0032 0.0074
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0032 0.0032
Trypanosoma brucei carbonic anhydrase-like protein 0.0379 0.345 1
Onchocerca volvulus Putative sulfate transporter 0.0198 0.1775 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0083 0.0107
Schistosoma mansoni hypothetical protein 0.0015 0.0083 0.0215
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0205 0.0205
Chlamydia trachomatis sulfate transporter 0.0032 0.0234 1
Trichomonas vaginalis conserved hypothetical protein 0.1086 1 1
Loa Loa (eye worm) hypothetical protein 0.0192 0.1722 0.496
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0192 0.1722 0.4961
Entamoeba histolytica hypothetical protein 0.0035 0.0264 0.0267
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0917 0.0917
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0032 0.0035
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0032 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0032 0.0032
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0205 0.0205
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0917 0.2613
Echinococcus multilocularis carbonic anhydrase II 0.0379 0.345 0.4775
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0083 0.0183
Leishmania major carbonic anhydrase family protein, putative 0.0269 0.243 0.5973
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0943 0.8673 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0032 0.0037
Schistosoma mansoni cpg binding protein 0.0028 0.0199 0.0537
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0032 0.0037
Schistosoma mansoni hypothetical protein 0.0164 0.1462 0.4039
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0032 0.0074
Schistosoma mansoni hypothetical protein 0.0033 0.0247 0.067
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0032 0.0037
Brugia malayi nuclear hormone receptor 0.001 0.0032 0.0035
Schistosoma mansoni cpg binding protein 0.0029 0.0214 0.0578
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0083 0.0183
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0032 0.0074
Schistosoma mansoni hypothetical protein 0.0015 0.0083 0.0215
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0205 0.0205
Plasmodium vivax sulfate transporter, putative 0.0032 0.0234 1
Schistosoma mansoni hypothetical protein 0.0164 0.1462 0.4039
Entamoeba histolytica hypothetical protein 0.0035 0.0264 0.0267
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0917 0.1264
Echinococcus granulosus FTZ F1 alpha 0.001 0.0032 0.0074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0032 0.0035
Schistosoma mansoni carbonic anhydrase-related 0.0192 0.1722 0.4758
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0032 0.0234 0.0188
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0032 0.0234 0.0188
Brugia malayi hypothetical protein 0.0035 0.0264 0.0712
Brugia malayi 6-phosphofructokinase 0.0105 0.0917 0.2615
Schistosoma mansoni hypothetical protein 0.0035 0.0264 0.0718
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0488 0.1338
Echinococcus multilocularis carbonic anhydrase 0.0192 0.1722 0.2379
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.043 0.1482
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0032 0.0074
Onchocerca volvulus 0.0028 0.0199 0.0959
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0264 0.0718
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0032 0.0074
Brugia malayi steroid hormone receptor 0.001 0.0032 0.0035
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0389 0.1075
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0917 0.2125
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0032 0.0037
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0247 0.0662
Brugia malayi CXXC zinc finger family protein 0.0028 0.0199 0.0522
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0917 0.32
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0083 0.0215
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0229 0.2059 0.1472
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Echinococcus multilocularis cpg binding protein 0.0029 0.0214 0.0289
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0032 0.0074
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0379 0.345 1
Trichomonas vaginalis conserved hypothetical protein 0.1086 1 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0379 0.345 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0032 0.0035
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0032 0.0037
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0379 0.345 1
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0269 0.243 1
Brugia malayi 6-phosphofructokinase 0.0105 0.0917 0.2615
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0032 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0032 0.0032
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0032 0.0074
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.7219 1
Onchocerca volvulus 0.0198 0.1775 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0032 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0032 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0032 0.0035
Toxoplasma gondii hypothetical protein 0.0192 0.1722 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0389 0.1072
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0032 0.0037
Brugia malayi phosphofructokinase 0.0105 0.0917 0.2615
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0032 0.0032
Echinococcus granulosus carbonic anhydrase 0.0192 0.1722 0.4758
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0389 0.1075
Echinococcus granulosus geminin 0.0164 0.1462 0.4039
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0917 0.2527
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0389 0.1072
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0021 0.0044
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0032 0.0074
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.3613 0.5
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0917 0.32
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0083 0.0107
Schistosoma mansoni carbonic anhydrase-related 0.0192 0.1722 0.4758
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0125 0.1103 0.0239
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0083 0.018
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0205 0.0205
Brugia malayi ecdysteroid receptor 0.001 0.0032 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0032 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0396 0.3613 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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