Detailed information for compound 582557

Basic information

Technical information
  • TDR Targets ID: 582557
  • Name: (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[( 2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[ (3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dih ydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-5-( hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydr oxy-cyclohexoxy]tetrahydropyran-3,4-diol; [2- [(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy- 10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16 -decahydro-1H-cyclopenta[a]phenanthren-17-yl] -2-oxo-ethyl] acetate
  • MW: 1019.14 | Formula: C46H78N6O19
  • H donors: 15 H acceptors: 12 LogP: -7.36 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 4
  • SMILES: CC(=O)OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C.OC[C@H]1O[C@H]([C@@H]([C@@H]1OC1O[C@@H](CN)[C@H]([C@@H]([C@H]1N)O)O)O)O[C@H]1[C@@H](O)[C@H](N)C[C@@H](C1O[C@H]1O[C@H](CN)[C@H]([C@@H]([C@H]1N)O)O)N
  • InChi: 1S/C23H46N6O13.C23H32O6/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h5-23,30-36H,1-4,24-29H2;10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18?,19-,20-,21-,22?,23+;16-,17-,18-,20+,21-,22-,23-/m10/s1
  • InChiKey: TXLRVPDJPXYDAY-QUOZIDONSA-N  


Substructure search Similarity search

Network

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Synonyms

  • acetic acid [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] ester; (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,6S)-4,6-diamino-2-[[(2S,3R,4S,5R)-4-[[(3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-2-tetrahydropyranyl]oxy]-3-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]oxy]-3-hydroxycyclohexoxy]tetrahydropyran-3,4-diol
  • (2R,3S,4R,5R,6R)-2-(aminomethyl)-6-[(2R,3S,4R,6S)-2-[(2S,3R,4S,5R)-4-[(3R,4R,5S,6S)-6-(aminomethyl)-3-azanyl-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-bis(azanyl)-3-hydroxy-cyclohexyl]oxy-5-azanyl-oxane-3,4-diol; [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] ethanoate
  • acetic acid [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-3-keto-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] ester; (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-5-methylol-tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol
  • (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol; [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
  • framycort
  • (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol; [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] ethanoate
  • 77536-65-3
  • Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11beta)-, mixt. with O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-beta-D-ribofuranosyl-(1-5))-2-deoxy-D-streptamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0016 0.0423 0.044
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0743 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0567 0.2129
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0473 0.0222
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.2663 0.4386
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0716 0.0522
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0027 0.0102
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0423 0.1501
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0027 0.0102
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0423 0.0423
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0027 0.0027
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0716 0.0522
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0716 0.094
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.6957 0.8837
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.348 0.348
Entamoeba histolytica recQ family helicase, putative 0.002 0.0716 0.722
Brugia malayi glutathione reductase 0.0047 0.2663 0.4255
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0473 0.169
Loa Loa (eye worm) hypothetical protein 0.0018 0.0567 0.0898
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0716 0.9001
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0473 0.0525
Echinococcus granulosus bloom syndrome protein 0.002 0.0716 0.0522
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0716 0.2689
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0743 0.279
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.6036 1
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.781 1
Schistosoma mansoni jumonji domain containing protein 0.0059 0.348 0.348
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0743 1
Plasmodium falciparum thioredoxin reductase 0.0047 0.2663 1
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0423 0.0423
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0423 0.0658
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0716 0.1309
Schistosoma mansoni ap endonuclease 0.002 0.0743 0.0743
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0498 0.0035
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0992 0.2539
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.6036 0.6036
Schistosoma mansoni DNA helicase recq5 0.002 0.0716 0.0716
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0716 0.9001
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0992 0.1409
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0743 0.2716
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0743 0.1191
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0716 0.1309
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0992 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0567 0.0898
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0473 0.169
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0743 0.2716
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0716 0.9001
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0743 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0992 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0498 0.0035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0473 0.169
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.2663 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0743 0.1429
Brugia malayi jmjC domain containing protein 0.0016 0.0423 0.044
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.348 0.5746
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0473 0.169
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.2663 1
Plasmodium falciparum glutathione reductase 0.0016 0.0473 0.0222
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0716 0.1309
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.6957 0.8837
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0423 0.0658
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0498 0.0035
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0473 0.0222
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0743 0.1429
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0473 0.0222
Leishmania major trypanothione reductase 0.0047 0.2663 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0716 0.0522
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.2663 0.2985
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0992 0.2539
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0567 0.1815
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0716 0.0522
Loa Loa (eye worm) hypothetical protein 0.0016 0.0423 0.0658
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0992 0.0707
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0423 0.1501
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0716 0.094
Trypanosoma brucei trypanothione reductase 0.0047 0.2663 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0473 0.0222
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.348 0.5447
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0473 0.169
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0743 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.00000000096404
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.6036 0.6036
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0473 0.1775
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0473 0.0089
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.6957 0.8837
Toxoplasma gondii exonuclease III APE 0.002 0.0743 0.279
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0992 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0716 0.1146
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0743 0.057
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0423 0.1588
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0567 0.0643
Loa Loa (eye worm) hypothetical protein 0.0016 0.0423 0.0658
Brugia malayi jmjC domain containing protein 0.0059 0.348 0.5647
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0473 0.169
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0423 0.0423
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0992 1
Echinococcus multilocularis bloom syndrome protein 0.002 0.0716 0.0522
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0992 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0992 0.0707
Toxoplasma gondii thioredoxin reductase 0.0047 0.2663 1
Loa Loa (eye worm) RecQ helicase 0.002 0.0716 0.1146
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0743 0.1429
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0473 0.169
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0992 1
Plasmodium vivax JmjC domain containing protein 0.0016 0.0423 0.1588
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0473 0.0222
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0473 0.0222
Brugia malayi Thioredoxin reductase 0.0047 0.2663 0.4255
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0992 0.2539
Mycobacterium tuberculosis Probable reductase 0.0108 0.6957 0.8837
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0473 0.0222
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.348 0.5447
Schistosoma mansoni ap endonuclease 0.002 0.0743 0.0743
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.781 1
Loa Loa (eye worm) glutathione reductase 0.0047 0.2663 0.4386
Plasmodium vivax glutathione reductase, putative 0.0047 0.2663 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.6036 0.6036
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0473 0.1775
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0716 0.2689
Entamoeba histolytica recQ family DNA helicase 0.001 0.0027 0.0275
Loa Loa (eye worm) hypothetical protein 0.0024 0.0992 0.1605
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0473 0.0222
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0423 0.1588
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0992 0.1409
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0473 0.169
Treponema pallidum NADH oxidase 0.0016 0.0473 0.6223
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0743 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0992 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.6957 0.8837
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0992 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0743 0.0986
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0473 0.1775
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.781 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0473 0.0222
Loa Loa (eye worm) hypothetical protein 0.0018 0.0567 0.0898
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.348 0.5447
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0473 0.0089
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.2663 0.3991
Loa Loa (eye worm) hypothetical protein 0.0016 0.0423 0.0658
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0992 0.1409
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0716 0.1146
Mycobacterium ulcerans hypothetical protein 0.0024 0.0992 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0473 0.169
Plasmodium falciparum glutathione reductase 0.0047 0.2663 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0423 0.0423
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0743 0.057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.6036 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0423 0.0658
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0743 0.0368
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.2663 0.3991
Onchocerca volvulus 0.0024 0.0992 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.6036 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0992 0.1605
Loa Loa (eye worm) hypothetical protein 0.0018 0.0567 0.0898
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0473 0.1775
Loa Loa (eye worm) hypothetical protein 0.0018 0.0567 0.0898
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0716 0.094
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0567 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.6957 0.8749
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.6036 1
Plasmodium falciparum thioredoxin reductase 0.0016 0.0473 0.0222
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.348 0.348
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.781 1
Brugia malayi jmjC domain containing protein 0.0059 0.348 0.5647
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0567 0.0128
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0992 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0498 0.0035
Loa Loa (eye worm) hypothetical protein 0.0024 0.0992 0.1605
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0992 1
Schistosoma mansoni DNA helicase recq1 0.002 0.0716 0.0716
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.6957 0.8837
Brugia malayi jmjC domain containing protein 0.0016 0.0423 0.044
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0423 0.0423
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.6036 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0473 0.0473
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.6036 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0716 0.1309
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0473 0.0222
Brugia malayi jmjC domain containing protein 0.0016 0.0423 0.044
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0743 0.5209
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.348 0.5447
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0743 0.7492
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0716 0.2613
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0716 0.9001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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