Detailed information for compound 583405

Basic information

Technical information
  • TDR Targets ID: 583405
  • Name: silver 2-hydroxybenzoic acid chlorate
  • MW: 329.44 | Formula: C7H6AgClO6
  • H donors: 2 H acceptors: 6 LogP: 3.17 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1ccccc1O.[O-][Cl](=O)=O.[Ag+]
  • InChi: 1S/C7H6O3.Ag.ClHO3/c8-6-4-2-1-3-5(6)7(9)10;;2-1(3)4/h1-4,8H,(H,9,10);;(H,2,3,4)/q;+1;/p-1
  • InChiKey: PXQGAYPVBJBCMZ-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • silver salicylic acid chlorate
  • silargent
  • 79084-80-3
  • Benzoic acid, 2-hydroxy-, mixt. with silver(1+) chlorate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0147 0.1693 1
Onchocerca volvulus 0.0024 0.0088 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0292 0.2714
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0696
Onchocerca volvulus 0.0049 0.0418 0.1627
Onchocerca volvulus 0.0214 0.257 1
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0698 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0033
Plasmodium falciparum stearoyl-CoA desaturase 0.0197 0.2344 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0088 0.0341
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0088 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0088 1
Loa Loa (eye worm) acyl-CoA desaturase 0.0197 0.2344 0.908
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0418 0.247
Leishmania major fatty-acid desaturase, putative 0.0214 0.257 1
Echinococcus granulosus chromobox protein 1 0.0071 0.0698 0.167
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0088 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0088 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.038 0.1473
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0088 1
Echinococcus multilocularis chromobox protein 1 0.0071 0.0698 0.0698
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0009 0.0971
Schistosoma mansoni hypothetical protein 0.0068 0.0662 0.391
Entamoeba histolytica hypothetical protein 0.0041 0.0309 0.2939
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.038 0.2246
Echinococcus multilocularis tumor protein p63 0.0337 0.4177 0.4177
Trypanosoma cruzi fatty acid desaturase, putative 0.0214 0.257 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.038 0.091
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0331 0.3419
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0215 0.2581 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0309 0.074
Trypanosoma cruzi fatty acid desaturase, putative 0.0197 0.2344 0.9119
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0009 0.5
Onchocerca volvulus 0.0214 0.257 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0418 0.162
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0033
Trypanosoma cruzi fatty acid desaturase, putative 0.0197 0.2344 0.9119
Schistosoma mansoni chromobox protein 0.0071 0.0698 0.412
Loa Loa (eye worm) hypothetical protein 0.0215 0.2581 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0088 1
Schistosoma mansoni hypothetical protein 0.0068 0.0662 0.391
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0662 0.0662
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0088 0.0342
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0662 0.2565
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0331 0.1287
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0088 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.038 0.091
Entamoeba histolytica hypothetical protein 0.0041 0.0309 0.2939
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0088 0.0342
Schistosoma mansoni chromobox protein 0.0071 0.0698 0.412
Loa Loa (eye worm) hypothetical protein 0.0068 0.0662 0.2565
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.084 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0341
Brugia malayi Calcitonin receptor-like protein seb-1 0.0215 0.2581 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0292 0.2714
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0662 0.1585
Toxoplasma gondii sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein 0.0017 0 0.5
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0698 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0088 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0662 0.2565
Brugia malayi chromobox protein homolog 3 0.004 0.0292 0.1129
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0088 0.0341
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.038 0.2246
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0292 0.1134
Brugia malayi hypothetical protein 0.0041 0.0309 0.1197
Loa Loa (eye worm) hypothetical protein 0.004 0.0292 0.1129
Brugia malayi Heterochromatin protein 1 0.0071 0.0698 0.2702
Echinococcus granulosus chromobox protein 1 0.0071 0.0698 0.167
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.0197 0.2344 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0088 0.5
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0088 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0088 0.0341
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0033
Trypanosoma brucei fatty acid desaturase, putative 0.0214 0.257 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0341
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0088 0.0342
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.038 0.2246
Echinococcus multilocularis chromobox protein 1 0.0071 0.0698 0.0698
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0215 0.2581 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0088 1
Brugia malayi acyl-CoA desaturase 0.0197 0.2344 0.908
Entamoeba histolytica hypothetical protein 0.0041 0.0309 0.2939
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0309 0.1825
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0331 0.3419
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0341
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0662 0.2565
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.038 0.1473
Schistosoma mansoni hypothetical protein 0.0041 0.0309 0.1825
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0033
Leishmania major stearic acid desaturase, putative 0.0214 0.257 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0082 0.084 0.3253
Schistosoma mansoni hypothetical protein 0.0068 0.0662 0.391
Loa Loa (eye worm) hypothetical protein 0.0147 0.1693 0.6558
Schistosoma mansoni hypothetical protein 0.0068 0.0662 0.391
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.038 0.038
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0009 0.0971
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0662 0.1585
Echinococcus granulosus tumor protein p63 0.0337 0.4177 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.038 0.038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0088 1
Entamoeba histolytica hypothetical protein 0.0041 0.0309 0.2939
Echinococcus granulosus GPCR family 2 0.0068 0.0662 0.1585
Onchocerca volvulus 0.0031 0.018 0.0699
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.084 1
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0698 0.2702
Brugia malayi latrophilin 2 splice variant baaae 0.0147 0.1693 0.6558
Echinococcus multilocularis GPCR, family 2 0.0068 0.0662 0.0662

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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